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1
المؤلفون: Ulrike Bacher, Laura Flückiger, Thomas Pabst, Carolyn Graber, Katja Seipel
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 8092, p 8092 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15
Seipel, Katja; Graber, Carolyn; Flückiger, Laura; Bacher, Vera; Pabst, Thomas (2021). Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia. International journal of molecular sciences, 22(15) MDPI 10.3390/ijms22158092 <http://dx.doi.org/10.3390/ijms22158092Test>مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_compound, 0302 clinical medicine, fluids and secretions, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, STAT5 Transcription Factor, Medicine, MCL1, Midostaurin, Biology (General), Spectroscopy, Trametinib, Kinase, ten-eleven translocation-2 (TET2), Myeloid leukemia, hemic and immune systems, General Medicine, 3. Good health, Computer Science Applications, DNA-Binding Proteins, Leukemia, Myeloid, Acute, Chemistry, myeloid leukemia cell differentiation protein (MCL1), 030220 oncology & carcinogenesis, embryonic structures, FLT3 Inhibitor, Combination therapy, QH301-705.5, tumor suppressor p53 (TP53), 610 Medicine & health, Thiophenes, Article, Catalysis, Dioxygenases, Inorganic Chemistry, 03 medical and health sciences, signal transducer and activator of transcription 5 (STAT5), acute myeloid leukemia (AML), Cell Line, Tumor, Proto-Oncogene Proteins, Humans, hematological malignancies, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, FMS-like tyrosine kinase 3 (FLT3), business.industry, Venetoclax, Tumor Suppressor Proteins, Organic Chemistry, Pyrimidines, 030104 developmental biology, fms-Like Tyrosine Kinase 3, chemistry, Cancer research, business
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a86caaa2cbf92ffdc34d64b704e8471Test
https://www.mdpi.com/1422-0067/22/15/8092Test -
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المؤلفون: Ulrike Bacher, Basil Kopp, Thomas Pabst, Katja Seipel
المصدر: Cancers, Vol 13, Iss 581, p 581 (2021)
Cancers
Volume 13
Issue 3
Seipel, Katja; Kopp, Basil; Bacher, Ulrike; Pabst, Thomas (2021). BMI1-Inhibitor PTC596 in Combination with MCL1 Inhibitor S63845 or MEK Inhibitor Trametinib in the Treatment of Acute Leukemia. Cancers, 13(3) MDPI AG 10.3390/cancers13030581 <http://dx.doi.org/10.3390/cancers13030581Test>مصطلحات موضوعية: 0301 basic medicine, Cancer Research, NPM1, CD34, 610 Medicine & health, BMI1 Inhibitor PTC596, myeloid cell leukemia 1 (MCL1), lcsh:RC254-282, Article, 03 medical and health sciences, meningioma 1 (MN1), 0302 clinical medicine, acute myeloid leukemia (AML), hemic and lymphatic diseases, Medicine, MCL1, neoplasms, Trametinib, Acute leukemia, business.industry, MEK inhibitor, Myeloid leukemia, myelodysplastic syndrome (MDS), lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1), 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, tumor suppressor protein 53 (TP53), Cancer research, business, hematopoietic progenitor cell antigen cluster of differentiation 34 (CD34)
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ba1f36042ffd3cdb925c7e8e62782eTest
https://www.mdpi.com/2072-6694/13/3/581Test -
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المؤلفون: Ulrike Bacher, Urban Novak, Beatrice U. Mueller, Thomas Pabst, Behrouz Mansouri Taleghani, Laura C. Alva, Katja Seipel
المصدر: Transfusion. 58:2365-2373
مصطلحات موضوعية: medicine.medical_specialty, Myeloid, Blood transfusion, business.industry, medicine.medical_treatment, Immunology, Myeloid leukemia, Hematology, Hematopoietic stem cell transplantation, medicine.disease, Gastroenterology, Transplantation, 03 medical and health sciences, Leukemia, 0302 clinical medicine, Autologous stem-cell transplantation, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Internal medicine, medicine, Immunology and Allergy, business, Hematopoietic Stem Cell Mobilization, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::90e093564c9159bba96f20bf2f7bbe0aTest
https://doi.org/10.1111/trf.14895Test -
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المؤلفون: Jeffrey R. Idle, Diren Beyoğlu, Thomas Pabst, Ulrike Bacher, Katja Seipel
المصدر: Cancers
Volume 12
Issue 10
Cancers, Vol 12, Iss 2842, p 2842 (2020)
Idle, Jeffrey R; Seipel, Katja; Bacher, Ulrike; Pabst, Thomas; Beyoğlu, Diren (2020). (2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia. Cancers, 12(10) MDPI AG 10.3390/cancers12102842 <http://dx.doi.org/10.3390/cancers12102842Test>مصطلحات موضوعية: 0301 basic medicine, Cancer Research, IDH1, Metabolite, Mutant, 610 Medicine & health, acute myeloid leukemia, medicine.disease_cause, IDH2, lcsh:RC254-282, Article, isocitrate dehydrogenase 2, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, isocitrate dehydrogenase 1, hemic and lymphatic diseases, medicine, (2R,3S)-dihydroxybutanoic acid, Threonine, (2R)-hydroxyglutaric acid, neoplasms, Mutation, Chemistry, Myeloid leukemia, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Molecular biology, metabolomics, oncometabolite, 030104 developmental biology, Isocitrate dehydrogenase, Oncology, 030220 oncology & carcinogenesis, biomarker
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe076355dce1805bc1443b2a8f4b884Test
http://europepmc.org/articles/PMC7600928Test -
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المصدر: Haematologica
مصطلحات موضوعية: Acute Myeloid Leukemia, Male, 0301 basic medicine, NPM1, Myeloid, HL-60 Cells, Article, 03 medical and health sciences, chemistry.chemical_compound, fluids and secretions, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Cytotoxic T cell, Midostaurin, Enzyme Inhibitors, biology, business.industry, Wild type, Myeloid leukemia, Proto-Oncogene Proteins c-mdm2, hemic and immune systems, Hematology, Staurosporine, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, medicine.anatomical_structure, fms-Like Tyrosine Kinase 3, chemistry, 030220 oncology & carcinogenesis, embryonic structures, biology.protein, Cancer research, Mdm2, Female, business, Nucleophosmin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d87a3f46f05337d04f986dc39c79468Test
https://doi.org/10.3324/haematol.2018.191650Test -
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المؤلفون: Gertrud Wiedemann, Ulrike Bacher, Katja Seipel, Thomas Pabst, Christian Messerli
المصدر: Leukemia research. 89
مصطلحات موضوعية: Adult, Male, Cancer Research, Myeloid, CD34, Peripheral blood mononuclear cell, Models, Biological, Transplantation, Autologous, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Autologous stem-cell transplantation, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Medicine, Humans, 610 Medicine & health, Aged, Retrospective Studies, business.industry, Tumor Suppressor Proteins, Hematopoietic Stem Cell Transplantation, Induction chemotherapy, Myeloid leukemia, Forkhead Transcription Factors, Hematology, Induction Chemotherapy, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Repressor Proteins, Haematopoiesis, Leukemia, Myeloid, Acute, MicroRNAs, medicine.anatomical_structure, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Trans-Activators, Female, Stem cell, business, Nucleophosmin, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df4593d94f150a7e9189cf98b99f336Test
https://pubmed.ncbi.nlm.nih.gov/31927137Test -
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المؤلفون: S Farese, Urban Novak, J-M Luethi, Gabriela M. Baerlocher, Thomas Pabst, Martin Bigler, Beatrice U. Mueller, B Mansouri Taleghani, Katja Seipel, Axel Ruefer, Barbara Jeker, Daniel Betticher
المصدر: Bone Marrow Transplantation. 53:175-179
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Urology, CD34, Pharmacology, Meloxicam, Vinorelbine, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 610 Medicine & health, Multiple myeloma, Aged, Peripheral Blood Stem Cell Transplantation, Transplantation, Chemotherapy, business.industry, Plerixafor, Anti-Inflammatory Agents, Non-Steroidal, Hematology, Middle Aged, medicine.disease, Hematopoietic Stem Cell Mobilization, Gemcitabine, 030220 oncology & carcinogenesis, Female, Multiple Myeloma, business, 030215 immunology, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d39d870a9a5dfeef02ee51221e0967Test
https://doi.org/10.1038/bmt.2017.234Test -
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المؤلفون: Urban Novak, Yara Banz, Alexander D Heini, Martin D. Berger, Katja Seipel, Kurt Leibundgut, Behrouz Mansouri Taleghani, Gabriela M. Baerlocher, Thomas Pabst
المصدر: Leukemia Research. 53:28-34
مصطلحات موضوعية: Male, Oncology, Cancer Research, medicine.medical_specialty, Transplantation Conditioning, Allogeneic transplantation, Cyclophosphamide, medicine.medical_treatment, Hematopoietic stem cell transplantation, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Autologous stem-cell transplantation, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Autologous transplantation, 610 Medicine & health, Busulfan, neoplasms, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Remission Induction, Age Factors, Hematopoietic Stem Cell Transplantation, Hematology, humanities, Surgery, Survival Rate, Leukemia, Myeloid, Acute, Treatment Outcome, 030220 oncology & carcinogenesis, 570 Life sciences, biology, Female, business, 030215 immunology, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53332fa4ce07a3bdc5671013846c1f63Test
https://doi.org/10.1016/j.leukres.2016.12.001Test -
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المؤلفون: Gabriela M. Baerlocher, Jasmin Stettler, Thomas Pabst, Katja Seipel, Urban Novak, Behrouz Mansouri Taleghani
المصدر: Stettler, Jasmin; Novak, Urban; Baerlocher, Gabriela M.; Seipel, Katja; Mansouri Taleghani, Behrouz; Pabst, Thomas (2017). Autologous stem cell transplantation in elderly patients with multiple myeloma: evaluation of its safety and efficacy. Leukemia & lymphoma, 58(5), pp. 1076-1083. Informa Healthcare 10.1080/10428194.2016.1233542 <http://dx.doi.org/10.1080/10428194.2016.1233542Test>
مصطلحات موضوعية: Adult, Male, Oncology, Melphalan, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, 610 Medicine & health, Kaplan-Meier Estimate, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Autologous stem-cell transplantation, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Multiple myeloma, Aged, Neoplasm Staging, Aged, 80 and over, Chemotherapy, business.industry, Platelet recovery, Age Factors, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, medicine.disease, Treatment related mortality, Surgery, Immunoglobulin Isotypes, Treatment Outcome, 030220 oncology & carcinogenesis, Toxicity, Female, Stem cell, Multiple Myeloma, business, Biomarkers, 030215 immunology, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2815c999de70734988055d204c9e59c2Test
https://doi.org/10.1080/10428194.2016.1233542Test -
10Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia
المؤلفون: Katja Seipel, Thomas Pabst, Ulrike Bacher, Karin Schmitter
المصدر: Cancers, Vol 11, Iss 11, p 1779 (2019)
Cancers
Volume 11
Issue 11
Seipel, Katja; Schmitter, Karin; Bacher, Ulrike; Pabst Müller, Thomas Niklaus (2019). Rationale for a Combination Therapy Consisting of MCL1-and MEK-Inhibitors in Acute Myeloid Leukemia. Cancers, 11(11) MDPI AG 10.3390/cancers11111779 <http://dx.doi.org/10.3390/cancers11111779Test>مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Myeloid, myeloid leukemia cell differentiation protein (mcl1), acute myeloid leukemia (aml), 610 Medicine & health, lcsh:RC254-282, Article, mitogen-activated protein kinase kinase (MEK, MAP2K, MAPKK), 03 medical and health sciences, 0302 clinical medicine, mapkk), tumor suppressor p53 (tp53), hemic and lymphatic diseases, medicine, MCL1, hematological malignancies, fms like tyrosine kinase 3 (flt3), mitogen-activated protein kinase kinase (mek, Trametinib, biology, Oncogene, Cell growth, business.industry, Myeloid leukemia, ribosomal protein s6 (rps6), medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Leukemia, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, map2k, Mdm2, business
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5359519e27088bb7edffadf3692f33aTest