المؤلفون: Fabian Model, Ludwig Kappos, Stephen L. Hauser, Heidemarie Kletzl, Ekaterina Gibiansky, Andreas Günther, Claire Petry, Ann Herman, Francois Mercier, Yumi Yamamoto, Qing Wang

المصدر: British Journal of Clinical Pharmacology
British journal of clinical pharmacology, vol 87, iss 6

مصطلحات موضوعية: Phases of clinical research, Relapsing-Remitting, Neurodegenerative, 030226 pharmacology & pharmacy, Gastroenterology, 0302 clinical medicine, population analysis, Monoclonal, Medicine, Pharmacology (medical), 030212 general & internal medicine, Pharmacology & Pharmacy, Humanized, education.field_of_study, Pharmacology and Pharmaceutical Sciences, Multiple Sclerosis, Chronic Progressive, Chronic Progressive, Original Article, medicine.drug, medicine.medical_specialty, Multiple Sclerosis, pharmacokinetic-pharmacodynamic, Population, Primary Progressive Multiple Sclerosis, Antibodies, Monoclonal, Humanized, Autoimmune Disease, Antibodies, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, Pharmacokinetics, Internal medicine, pharmacokinetic–pharmacodynamic, pharmacodynamics, Humans, Immunologic Factors, In patient, education, Pharmacology, business.industry, Multiple sclerosis, neurology, pharmacokinetic–, Neurosciences, Original Articles, medicine.disease, Brain Disorders, pharmacodynamic, Pharmacodynamics, Ocrelizumab, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8811580eb5543d689634ed86d7b68a05Test
http://europepmc.org/articles/PMC8247316Test

المؤلفون: Heidemarie Kletzl, D. Vlodavets, Marianne Gerber, Sabine Fuerst-Recktenwald, Maria Mazurkiewicz-Bełdzińska, Basil T. Darras, M. El-Khairi, Giovanni Baranello, Ksenija Gorni, Renata S. Scalco, Riccardo Masson, H. Xiong, Kristy Rose, Edmar Zanoteli, Laurent Servais

المصدر: Web of Science

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, business.industry, Gross motor skill, Spinal muscular atrophy, medicine.disease, Sitting, SMA, Bayley Scales of Infant Development, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Tolerability, medicine, Clinical endpoint, 030212 general & internal medicine, Toddler, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac31266581f9dd75f3911be295696a45Test
https://doi.org/10.1183/13993003.congress-2020.1172Test

المؤلفون: Heidemarie Kletzl, A. Höflich, Friedrich Metzger, Eginhard Schick, Christoph Wandel, Norbert Bleich, C. Höflich, R.F. Staack, Andreas Guenther, Jan Frystyk

المصدر: Kletzl, H, Guenther, A, Höflich, A, Höflich, C, Frystyk, J, Staack, R F, Schick, E, Wandel, C, Bleich, N & Metzger, F 2017, ' First-in-man study with a novel PEGylated recombinant human insulin-like growth factor-I ', Growth Hormone & I G F Research, vol. 33, pp. 9-16 . https://doi.org/10.1016/j.ghir.2017.01.001Test

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Maximum Tolerated Dose, Erythema, Endocrinology, Diabetes and Metabolism, Hypoglycemia, Polyethylene Glycols, 03 medical and health sciences, Subcutaneous injection, 0302 clinical medicine, Endocrinology, Double-Blind Method, Pharmacokinetics, Internal medicine, medicine, Humans, Tissue Distribution, Insulin-Like Growth Factor I, Growth Substances, First-in-man study, Dose-Response Relationship, Drug, business.industry, Prognosis, medicine.disease, Recombinant Proteins, 030104 developmental biology, Tolerability, Pharmacodynamics, PEGylation, Female, medicine.symptom, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830323b68af1ea8d8ea70fdc93cf9300Test
https://doi.org/10.1016/j.ghir.2017.01.001Test

المؤلفون: Lauren Boak, Omar Khwaja, Daniel Umbricht, Christophe Grundschober, James T. McCracken, Eric Hollander, Heidemarie Kletzl, Lisa Squassante, Marta del Valle Rubido, Frederick Shic, Jana Noeldeke, Lawrence Scahill, Paulo Fontoura

المصدر: Neuropsychopharmacology

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Receptors, Vasopressin, Vasopressin, medicine.medical_specialty, Indoles, Adolescent, Autism Spectrum Disorder, medicine.drug_class, Pharmacology, High functioning, law.invention, Young Adult, 03 medical and health sciences, Cognition, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, medicine, Humans, Spiro Compounds, Psychiatry, Receptor, Psychotropic Drugs, Cross-Over Studies, Mechanism (biology), Communication, Middle Aged, medicine.disease, Receptor antagonist, Crossover study, Psychiatry and Mental health, Treatment Outcome, 030104 developmental biology, Social Perception, Autism spectrum disorder, Original Article, Corrigendum, Psychology, 030217 neurology & neurosurgery, Preliminary Data

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb3089c290e8c76df240cee68616bffTest
https://doi.org/10.1038/npp.2016.232Test

المؤلفون: Jules A. A. C. Heuberger, Eugenio Mercuri, Katja Heinig, Russell Kinch, Andreas Günther, Irene Gerlach, Wakana Tang, Teodorica L. Bugawan, Omar Khwaja, Geert Jan Groeneveld, W. Birkhoff, Heidemarie Kletzl, Claire L Wood, Hanns Lochmüller, Sebastian Dziadek, Dirk Fischer, Christian Czech, Anne Marquet

المصدر: Neuromuscular disorders : NMD. 29(1)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, animal diseases, Administration, Oral, SMN1, Bioinformatics, spinal muscular atrophy, Muscular Atrophy, Spinal, 03 medical and health sciences, Exon, Young Adult, Settore MED/39 - NEUROPSICHIATRIA INFANTILE, 0302 clinical medicine, Double-Blind Method, medicine, Humans, RNA, Messenger, Child, Genetics (clinical), business.industry, Alternative splicing, Infant, Survival of motor neuron, Spinal muscular atrophy, Motor neuron, Middle Aged, medicine.disease, SMA, Muscle atrophy, nervous system diseases, Survival of Motor Neuron 2 Protein, Alternative Splicing, 030104 developmental biology, medicine.anatomical_structure, Pyrimidines, nervous system, Neurology, Neuromuscular Agents, Child, Preschool, Pyrazines, Pediatrics, Perinatology and Child Health, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd3af212d2a80d491e04b1614b29a09Test
https://pubmed.ncbi.nlm.nih.gov/30553700Test

المؤلفون: Yumi Cleary, Katja Heinig, Lutz Müller, Hasane Ratni, Omar Khwaja, Nicolas Frances, Paul Jordan, Agnès Poirier, Birgit Jaber, Tobias Bergauer, Heidemarie Kletzl, Nada Al Kotbi, Stefan Sturm, Anne Marquet, Andreas Günther, Christian Czech, Nikhat Parkar

المصدر: British journal of clinical pharmacology. 85(1)

مصطلحات موضوعية: Adult, Male, Adolescent, CYP3A, Itraconazole, RNA Splicing, Administration, Oral, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Muscular Atrophy, Spinal, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, Medicine, Humans, Pharmacology (medical), Drug Interactions, 030212 general & internal medicine, RNA, Messenger, Volunteer, business.industry, Original Articles, Middle Aged, Confidence interval, Healthy Volunteers, Survival of Motor Neuron 2 Protein, Pyrimidines, Tolerability, Neuromuscular Agents, Pharmacodynamics, Area Under Curve, Cytochrome P-450 CYP3A Inhibitors, business, Azo Compounds, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a179691a66077906bc034e6725650dTest
https://pubmed.ncbi.nlm.nih.gov/30302786Test

المؤلفون: S. Sturm, John W. Day, Ksenija Gorni, Y. Cleary, Dirk Fischer, L. Servais, Eugenio Mercuri, Heidemarie Kletzl, Janbernd Kirschner, Maria Carmela Pera, Nicolas Deconinck, Andrea Klein, Riccardo Masson, Nathalie Goemans, Christian Czech, Andreas Günther, Claudia A. Chiriboga, Omar Khwaja, Basil T. Darras, Giovanni Baranello

المصدر: Neuromuscular Disorders. 28:S109-S110

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, business.industry, SMA, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Neurology, Internal medicine, Pediatrics, Perinatology and Child Health, Medicine, Neurology (clinical), business, 030217 neurology & neurosurgery, Genetics (clinical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ea05adadbc5deddbf33c263194249cTest
https://doi.org/10.1016/j.nmd.2018.06.307Test

المؤلفون: Norcross Roger, Moshe Finel, Nenad Manevski, Victor A. Iglesias, Marius C. Hoener, Dietrich Tuerck, Stephen Fowler, Paul Schmid, Olivia Spleiss, Heidemarie Kletzl

المصدر: Journal of Pharmacology and Experimental Therapeutics. 352:358-367

مصطلحات موضوعية: UGT1A4, Glucuronidation, Black People, Pharmacology, Biology, Polymorphism, Single Nucleotide, 030226 pharmacology & pharmacy, DNA sequencing, Substrate Specificity, law.invention, 03 medical and health sciences, Glucuronides, 0302 clinical medicine, Tandem Mass Spectrometry, law, Humans, Gene Silencing, Glucuronosyltransferase, Oxazoles, Cells, Cultured, Chromatography, High Pressure Liquid, 030304 developmental biology, Genetics, chemistry.chemical_classification, 0303 health sciences, Splice site mutation, 3. Good health, Enzyme, chemistry, Drug development, RNA splicing, Microsomes, Liver, Recombinant DNA, Molecular Medicine, Databases, Nucleic Acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8172f13f9cad04a04e634c848f42a827Test
https://doi.org/10.1124/jpet.114.220194Test

المؤلفون: Miriam Pein-Hackelbusch, Heidemarie Kletzl, Stefan Sturm, Peter Kühl, Laura Isabell Immohr, Andreas Günther, Angela Dischinger

المصدر: International journal of pharmaceutics. 530(1-2)

مصطلحات موضوعية: Adult, Male, Taste, Electronic tongue, Chemistry, Pharmaceutical, Pharmaceutical Science, 02 engineering and technology, Pharmacology, Oral cavity, 030226 pharmacology & pharmacy, Excipients, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Tongue, Medicine, Humans, Palatability, Electronic Nose, business.industry, Healthy subjects, 021001 nanoscience & nanotechnology, Pediatric drug, medicine.anatomical_structure, 0210 nano-technology, business, Oral retinoid, Cognitive psychology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9595a91512e275eeb1872b2a5679567Test
https://pubmed.ncbi.nlm.nih.gov/28750893Test

المؤلفون: John W. Day, Eugenio Mercuri, Nicolas Deconinck, L Servais, Heidemarie Kletzl, R. Masson, Marianne Gerber, Ksenija Gorni, Y. Cleary, C Cabalteja, Andrea Klein, T. Seabrook, M. El-Khairi, Basil T. Darras, Omar Khwaja, K. Gelblin, Christian Czech, Giovanni Baranello, C. Nguyen

المصدر: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 46:S31

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, business.industry, Survival of motor neuron, General Medicine, Spinal muscular atrophy, SMN1, 030105 genetics & heredity, SMA, Interim analysis, medicine.disease, Gastroenterology, Motor function, nervous system diseases, 03 medical and health sciences, 0302 clinical medicine, Neurology, Pharmacokinetics, Tolerability, Internal medicine, medicine, Neurology (clinical), business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::193a4e5d38d8fcc2daf66d9496b47a16Test
https://doi.org/10.1017/cjn.2019.164Test