Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15
| العنوان: | Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15 |
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| المؤلفون: | Ma. Cinta Lleixà, Julio Pardo, Luana Benedetti, Alicia Martínez-Piñeiro, Yusuf A. Rajabally, Alejandra Carvajal, Jordi Díaz-Manera, Guiseppe Lauria, Emilien Delmont, Luis Querol, Enrico Marchioni, Diego Franciotta, Ana M. Siles, Isabel Illa, Laura Martínez-Martínez, Jérôme Devaux, Gemma Boera-Carnicero, Shahram Attarian, Ilaria Callegari, Oscar de la Calle Martin, Cándido Juárez, Andrea Cortese |
| المصدر: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-6 (2017) Journal of Neuroinflammation r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Genotype, Immunology, Human leukocyte antigen, CIDP, Autoantigens, lcsh:RC346-429, Antibodies, HLA DRB1*15, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Antigen, Gene Frequency, Medicine, Humans, Genetic Predisposition to Disease, Nerve Growth Factors, Risk factor, Allele, HLA-DRB1, Allele frequency, lcsh:Neurology. Diseases of the nervous system, Aged, Autoantibodies, biology, business.industry, General Neuroscience, Research, Polyradiculoneuropathy, NF155, Middle Aged, medicine.disease, 030104 developmental biology, Neurology, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Case-Control Studies, biology.protein, Female, Antibody, business, Cell Adhesion Molecules, 030217 neurology & neurosurgery, HLA-DRB1 Chains |
| الوصف: | Background The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. Methods Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included in a case-control study. The frequencies of the DRB1 HLA allele were analyzed in all patients while DQ frequencies were only studied in patients sharing the DRB1*15 allele. In silico HLA-peptide binding and NF155 antigenicity, predictions were performed to analyze overlap between presented peptides and antigenic regions. Results DRB1*15 alleles (DRB1*15:01 and DRB1*15:02) were present in 10 out of 13 anti-NF155+ CIDP patients and in only 5 out of 35 anti-NF155neg CIDP patients (77 vs 14%; OR = 20, CI = 4.035 to 99.13). DRB1*15 alleles appeared also in significantly higher proportions in anti-NF155+ CIDP than in normal population (77 vs 17%; OR = 16.9, CI = 4.434 to 57.30). Seven anti-NF155+ CIDP patients (53%) and 5 anti-NF155neg CIDP patients had the DRB1*15:01 allele (OR = 7, p = 0.009), while 3 anti-NF155+ CIDP patients and none of the anti-NF155neg CIDP patients had the DRB1*15:02 allele (OR = 23.6, p = 0.016). In silico analysis of the NF155 peptides binding to DRB1*15 alleles showed significant overlap in the peptides presented by the 15:01 and 15:02 alleles, suggesting functional homology. Conclusions DRB1*15 alleles are the first strong risk factor associated to a CIDP subset, providing additional evidence that anti-NF155+ CIDP patients constitute a differentiated disease within the CIDP syndrome. Electronic supplementary material The online version of this article (10.1186/s12974-017-0996-1) contains supplementary material, which is available to authorized users. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1742-2094 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c737363521fdf7dc61ce951ed10663Test https://hdl.handle.net/10668/11806Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....42c737363521fdf7dc61ce951ed10663 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17422094 |
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