Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study)
| العنوان: | Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study) |
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| المؤلفون: | H. J. F. Brenkman, E. C. Gertsen, E. Vegt, R. van Hillegersberg, M. I. van Berge Henegouwen, S. S. Gisbertz, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, J. J. B. van Lanschot, S. M. Lagarde, W. O. de Steur, H. H. Hartgrink, J. H. M. B. Stoot, K. W. E. Hulsewe, E. J. Spillenaar Bilgen, M. J. van Det, E. A. Kouwenhoven, D. L. van der Peet, F. Daams, J. W. van Sandick, N. C. T. van Grieken, J. Heisterkamp, B. van Etten, J. W. Haveman, J. P. Pierie, F. Jonker, A. Y. Thijssen, E. J. T. Belt, P. van Duijvendijk, E. Wassenaar, H. W. M. van Laarhoven, F. J. Wessels, N. Haj Mohammad, H. F. van Stel, G. W. J. Frederix, P. D. Siersema, J. P. Ruurda, on behalf of the PLASTIC Study Group |
| المساهمون: | Surgery, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and Quality of Life, CCA - Imaging and biomarkers, Oncology, Lifelong Learning, Education & Assessment Research Network (LEARN), CCA - Cancer Treatment and quality of life, AGEM - Digestive immunity, Pathology, VU University medical center |
| المصدر: | BMC Cancer, Vol 18, Iss 1, Pp 1-7 (2018) BMC Cancer BMC Cancer, 18. BIOMED CENTRAL LTD BMC cancer, 18(1):450. BioMed Central BMC Cancer, 18 on behalf of the PLASTIC Study Group 2018, ' Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: A multicenter prospective study (PLASTIC-study) ', BMC Cancer, vol. 18, no. 1, 450 . https://doi.org/10.1186/s12885-018-4367-9Test BMC Cancer, 18:450. BioMed Central Ltd. BMC Cancer, 18:450. BMC BMC Cancer, 18(1):450. BioMed Central BMC Cancer, 18(1). BioMed Central |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Cancer Research, SURGERY, NETHERLANDS, medicine.medical_treatment, Multimodal Imaging, Workflow, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], CYTOLOGY, Study Protocol, 0302 clinical medicine, TUMOR, Quality of life, Surgical oncology, Prospective Studies, Laparoscopy, Prospective cohort study, OUTCOMES, medicine.diagnostic_test, Advanced gastric cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PERITONEAL CARCINOMATOSIS, 3. Good health, Oncology, 030220 oncology & carcinogenesis, INTRAPERITONEAL CHEMOTHERAPY, 030211 gastroenterology & hepatology, Female, Radiology, Cohort study, medicine.medical_specialty, Adenocarcinoma, lcsh:RC254-282, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Stomach Neoplasms, Gastrectomy, Genetics, medicine, Humans, METAANALYSIS, Neoplasm Staging, business.industry, Cancer, medicine.disease, Positron-Emission Tomography, business, Tomography, X-Ray Computed, Gastric cancer |
| الوصف: | Contains fulltext : 193356.pdf (Publisher’s version ) (Open Access) BACKGROUND: Initial staging of gastric cancer consists of computed tomography (CT) and gastroscopy. In locally advanced (cT3-4) gastric cancer, fluorodeoxyglucose positron emission tomography with CT (FDG-PET/CT or PET) and staging laparoscopy (SL) may have a role in staging, but evidence is scarce. The aim of this study is to evaluate the impact and cost-effectiveness of PET and SL in addition to initial staging in patients with locally advanced gastric cancer. METHODS: This prospective observational cohort study will include all patients with a surgically resectable, advanced gastric adenocarcinoma (cT3-4b, N0-3, M0), that are scheduled for treatment with curative intent after initial staging with gastroscopy and CT. The modalities to be investigated in this study is the addition of PET and SL. The primary outcome of this study is the proportion of patients in whom the PET or SL lead to a change in treatment strategy. Secondary outcome parameters are: diagnostic performance, morbidity and mortality, quality of life, and cost-effectiveness of these additional diagnostic modalities. The study recently started in August 2017 with a duration of 36 months. At least 239 patients need to be included in this study to demonstrate that the diagnostic modalities are break-even. Based on the annual number of gastrectomies in the participating centers, it is estimated that approximately 543 patients are included in this study. DISCUSSION: In this study, it is hypothesized that performing PET and SL for locally advanced gastric adenocarcinomas results in a change of treatment strategy in 27% of patients and an annual cost-reduction in the Netherlands of euro916.438 in this patient group by reducing futile treatment. The results of this study may be applicable to all countries with comparable treatment algorithms and health care systems. TRIAL REGISTRATION: NCT03208621 . This trial was registered prospectively on June 30, 2017. |
| وصف الملف: | application/pdf; image/pdf |
| اللغة: | English |
| تدمد: | 1471-2407 0320-8621 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bd0ede63ed13742c2e3cdd76664f69Test http://link.springer.com/article/10.1186/s12885-018-4367-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d6bd0ede63ed13742c2e3cdd76664f69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712407 03208621 |
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