Coagulation disorders and thromboembolic disease in COVID-19: review of current evidence in search of a better approach
| العنوان: | Coagulation disorders and thromboembolic disease in COVID-19: review of current evidence in search of a better approach |
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| المؤلفون: | Diego Castillo-Villegas, Miguel Ángel Martínez-García, Alberto García-Ortega, Grace Oscullo, David de la Rosa, Raquel López-Reyes |
| المصدر: | J Thorac Dis Journal of Thoracic Disease r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Pulmonary embolism (PE), ARDS, medicine.medical_specialty, Review Article, 030204 cardiovascular system & hematology, Asymptomatic, D-dimer, Pulmonary embolism (PE), coronavirus disease 2019 (COVID-19), inflammation, thrombosis, 03 medical and health sciences, 0302 clinical medicine, Intensive care, medicine, Coagulopathy, Cumulative incidence, 030212 general & internal medicine, Endothelial dysfunction, Intensive care medicine, Coagulation Disorder, thrombosis, business.industry, medicine.disease, Pneumonia, inflammation, D-dimer, coronavirus disease 2019 (COVID-19), medicine.symptom, business |
| الوصف: | The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been an unprecedented global health problem, causing more than 20 million infections and more than 900,000 deaths (September 2020). The SARS-CoV-2 infection, known as COVID-19, has various clinical presentations, from asymptomatic or mild catarrhal processes to severe pneumonia that rapidly progresses to acute respiratory distress syndrome (ARDS) and multiple organ failure. In the last few months, much scientific literature has been devoted to descriptions of different aspects of the coagulation disorders and arterial and venous thrombotic complications associated with COVID-19, particularly venous thromboembolism (VTE). These studies have revealed that SARS-CoV-2 could lead to a prothrombotic state reflecting the high cumulative incidence of associated thrombotic events, particularly in patients admitted to intensive care units (ICUs). As regards the coagulopathy observed in association with SARS-CoV-2 infection, the mechanisms that activate coagulation have been hypothesized as being linked to immune responses, through the release of pro-inflammatory mediators that interact with platelets, stimulate the expression of tissue factor, induce an upregulation of plasminogen activator inhibitor-1, suppress the fibrinolytic system and lead to endothelial dysfunction, triggering thrombogenesis. D-dimer elevation has been recognized as a useful biomarker of poor prognosis, although the best cut-off point for predicting VTE in COVID-19 patients has still not been clarified. This review will try to update all the available scientific information on this important topic with enormous clinical and therapeutic implications. |
| اللغة: | English |
| تدمد: | 2072-1439 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fcebca3de07dbfe1ed3b38e176850eTest https://europepmc.org/articles/PMC7947499Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f8fcebca3de07dbfe1ed3b38e176850e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20721439 |
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