يعرض 21 - 30 نتائج من 39 نتيجة بحث عن '"Brian S. J. Blagg"', وقت الاستعلام: 1.17s تنقيح النتائج
  1. 21
    KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons

    المؤلفون: Brian S. J. Blagg, Rick T. Dobrowsky, Zhenyuan You, Zheng Zhang

    المصدر: Experimental neurology. 313

    مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Bioenergetics, Sensory Receptor Cells, Down-Regulation, medicine.disease_cause, Neuroprotection, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Oxygen Consumption, Developmental Neuroscience, Downregulation and upregulation, Diabetic Neuropathies, Superoxides, Internal medicine, Heat shock protein, Phenethylamines, medicine, Animals, HSP70 Heat-Shock Proteins, Glycosides, Mice, Knockout, Superoxide, Superoxide Dismutase, Wild type, Hsp70, Mitochondria, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Neurology, chemistry, Hyperglycemia, Female, Energy Metabolism, 030217 neurology & neurosurgery, Oxidative stress

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d224c58efffe641290f82315151c0dTest
    https://pubmed.ncbi.nlm.nih.gov/30557564Test


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  2. 22
    Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion

    المؤلفون: Mark S. Cohen, Qing Zhu, Barbara N. Timmermann, Chitra Subramanian, Peter T. White, Robert J. Gallagher, Brian S. J. Blagg, Huaping Zhang, Huiping Zhao

    المصدر: Surgery. 159:142-151

    مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Thyroid Gland, 03 medical and health sciences, 0302 clinical medicine, Western blot, Cell Movement, Cell Line, Tumor, Internal medicine, medicine, Anticarcinogenic Agents, Humans, Neoplasm Invasiveness, HSP90 Heat-Shock Proteins, Thyroid Neoplasms, Protein kinase B, Thyroid cancer, Cell Proliferation, biology, medicine.diagnostic_test, Cell growth, CD44, Thyroid, Cell migration, medicine.disease, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, biology.protein, Cancer research, Surgery, Stem cell

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697b350852499ba66ae63c62d41f7bc6Test
    https://doi.org/10.1016Test/j.surg.2015.07.050


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  3. 23
    Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding

    المؤلفون: Daniel T. Gewirth, Nanette L.S. Que, Adam S. Duerfeldt, Brian S. J. Blagg, Jinbo Zhao, Caitlin N. Kent, Vincent M. Crowley

    المصدر: Journal of medicinal chemistry. 61(7)

    مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Stereochemistry, Substituent, Molecular Conformation, Crystallography, X-Ray, Insert (molecular biology), Article, 03 medical and health sciences, Residue (chemistry), chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Adenosine Triphosphate, Dogs, Drug Discovery, Imidazole, Animals, Humans, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, biology, Chemistry, Membrane Proteins, Ligand (biochemistry), Hsp90, 030104 developmental biology, Cytoplasm, 030220 oncology & carcinogenesis, Drug Design, biology.protein, Molecular Medicine, Structure based, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccca754a8ee05065988cd16059cab867Test
    https://pubmed.ncbi.nlm.nih.gov/29528635Test


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  4. 24
    Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma

    المؤلفون: Haian Fu, Vincent M. Crowley, Chad A. Dickey, Yuhong Du, Raquel L. Lieberman, Dustin J. E. Huard, Laura J. Blair, Zheying Sun, Brian S. J. Blagg, Moya O. Tomlin, Ricardo A. Cordova, John Koren

    المصدر: ACS chemical biology. 13(4)

    مصطلحات موضوعية: 0301 basic medicine, genetic structures, Mutant, Crystallography, X-Ray, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, Humans, HSP90 Heat-Shock Proteins, Binding site, Eye Proteins, Myocilin, Glycoproteins, Gene knockdown, Extracellular Matrix Proteins, Membrane Glycoproteins, biology, Chemistry, Endoplasmic reticulum, Glaucoma, General Medicine, Hsp90, In vitro, eye diseases, Cell biology, High-Throughput Screening Assays, Molecular Docking Simulation, Cytoskeletal Proteins, 030104 developmental biology, Chaperone (protein), 030221 ophthalmology & optometry, biology.protein, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c26a3f0983d6af098ac50d7e7612fbcTest
    https://pubmed.ncbi.nlm.nih.gov/29402077Test


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  5. 25
    Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

    المؤلفون: Timothy A.J. Haystead, Brian S. J. Blagg, Len Neckers, Jane B. Trepel, Luke Whitesell, Didier Picard

    المصدر: Cell Stress and Chaperones, Vol. 23, No 4 (2018) pp. 467-482

    مصطلحات موضوعية: 0301 basic medicine, Molecular chaperones, Secondary effects, Hsp90, Computational biology, Disease, Biology, Hsf1, Biochemistry, Off-target effects, Hsp90 inhibitor, 03 medical and health sciences, 0302 clinical medicine, Clinical trials, Adenosine Triphosphate, ddc:570, Neoplasms, medicine, Animals, Humans, HSP90 Heat-Shock Proteins, HSF1, Cancer, Clinical Trials as Topic, Inhibitors, Neurodegeneration, Immunity, Reproducibility of Results, Cell Biology, medicine.disease, Small molecule, 030104 developmental biology, Proteostasis, 030220 oncology & carcinogenesis, biology.protein, Perspective and Reflection Article

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f68c124bf37da487a4a38361f889e7dTest
    https://europepmc.org/articles/PMC6045531Test/


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  6. 26
    Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

    المؤلفون: Dustin J. E. Huard, John Koren, Laura J. Blair, Jack M. Webster, Bryce A. Nordhues, Christopher L. Passaglia, Brian S. J. Blagg, Vincent M. Crowley, Raquel L. Lieberman, Andrew R. Stothert, Xiaolan Tang, Amirthaa Suntharalingam, Sanket J. Mishra, Chad A. Dickey

    المصدر: Scientific Reports
    Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

    مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Gene isoform, genetic structures, Mutant, lcsh:Medicine, Mice, Transgenic, Article, 03 medical and health sciences, 0302 clinical medicine, Heat shock protein, Animals, HSP90 Heat-Shock Proteins, lcsh:Science, Myocilin, Membrane Glycoproteins, Multidisciplinary, biology, Chemistry, lcsh:R, Phenotype, Hsp90, eye diseases, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, lcsh:Q, Protein folding, sense organs, Glaucoma, Open-Angle

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adec88378146352dcc630329f482d810Test
    https://doi.org/10.1038/s41598-017-18344-4Test


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  7. 27
    c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

    المؤلفون: David R. Loiselle, Chrisostomos Prodromou, Mehdi Mollapour, Jane B. Trepel, Taylor C. Remillard, Matthias P. Mayer, Len Neckers, Gennady Bratslavsky, Tiffany Caza, Lucas S. Franco, Diana M. Dunn, Barry Panaretou, Mark R. Woodford, Dimitra Bourboulia, William G. Stetler-Stevenson, Soumya Daturpalli, Jacqualyn J. Schulman, Andrew W. Truman, Sandra M. Jensen, Brian S. J. Blagg, Donald Wolfgeher, Timothy A.J. Haystead, Stephen J. Kron, Rhodri M. L. Morgan, Steve K. Landas

    المصدر: Cell reports
    Cell Reports, Vol 12, Iss 6, Pp 1006-1018 (2015)
    Dunn, D M, Woodford, M R, Truman, A W, Jensen, S M, Schulman, J, Caza, T, Remillard, T C, Loiselle, D, Wolfgeher, D, Blagg, B S J, Franco, L, Haystead, T A, Daturpalli, S, Mayer, M P, Trepel, J B, Morgan, R M L, Prodromou, C, Kron, S J, Panaretou, B, Stetler-Stevenson, W G, Landas, S K, Neckers, L, Bratslavsky, G, Bourboulia, D & Mollapour, M 2015, ' c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells ', Cell Reports, vol. 12, no. 6, pp. 1006-1018 . https://doi.org/10.1016Test/j.celrep.2015.07.004

    مصطلحات موضوعية: Proteasome Endopeptidase Complex, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Heat shock protein, polycyclic compounds, Humans, Immunoprecipitation, HSP90 Heat-Shock Proteins, Phosphorylation, Proto-Oncogene Proteins c-abl, lcsh:QH301-705.5, 030304 developmental biology, 0303 health sciences, biology, Kinase, Tyrosine phosphorylation, Hsp90, 3. Good health, Cell biology, HEK293 Cells, Proteasome, chemistry, lcsh:Biology (General), 030220 oncology & carcinogenesis, Chaperone (protein), Immunology, biology.protein, Intracellular, Molecular Chaperones

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858a1df9432de7672830f0234db3dfdaTest
    http://europepmc.org/articles/PMC4778718Test


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  8. 28
    A Scaffold Merging Approach to Hsp90 C-terminal Inhibition: Synthesis and Evaluation of a Chimeric Library

    المؤلفون: Rachel E. Davis, Brian S. J. Blagg, Zheng Zhang

    المصدر: MedChemComm. 8(3)

    مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Scaffold, Organic Chemistry, Binding pocket, Pharmaceutical Science, Biology, Biochemistry, Hsp90, Combinatorial chemistry, Article, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Drug Discovery, biology.protein, Molecular Medicine

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8220532573b62ad55d6456da419011f3Test
    https://pubmed.ncbi.nlm.nih.gov/28533894Test


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  9. 29
    Resorcinol-Based Grp94-Selective Inhibitors

    المؤلفون: Vincent M. Crowley, Anuj Khandelwal, Brian S. J. Blagg

    المصدر: ACS medicinal chemistry letters. 8(10)

    مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, biology, Glucose-regulated protein, Endoplasmic reticulum, Organic Chemistry, Resorcinol, Selective inhibition, Biochemistry, Hsp90, Amino acid, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, 030220 oncology & carcinogenesis, Heat shock protein, Drug Discovery, biology.protein, Selectivity

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d27185e951b96f0556c06512b846b94Test
    https://pubmed.ncbi.nlm.nih.gov/29057043Test


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  10. 30
    Cruentaren A Binds F1F0 ATP Synthase To Modulate the Hsp90 Protein Folding Machinery

    المؤلفون: Brian S. J. Blagg, Jessica Ann Hall, Bhaskar Reddy Kusuma, Gary E. L. Brandt

    المصدر: ACS Chemical Biology

    مصطلحات موضوعية: Protein Folding, Blotting, Western, Plasma protein binding, Protein degradation, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, 0302 clinical medicine, Immunophilins, Cruentaren, Cell Line, Tumor, polycyclic compounds, Humans, HSP90 Heat-Shock Proteins, Heat shock, 030304 developmental biology, 0303 health sciences, ATP synthase, biology, Dose-Response Relationship, Drug, Molecular Structure, General Medicine, Articles, Mitochondrial Proton-Translocating ATPases, Hsp90, 3. Good health, Cell biology, chemistry, 030220 oncology & carcinogenesis, biology.protein, MCF-7 Cells, Molecular Medicine, Protein folding, Macrolides, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1055e5ed64fe3c42e420d89bc5ca8f01Test
    http://europepmc.org/articles/PMC4090037Test


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