The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation
| العنوان: | The European Society for Blood and Marrow Transplantation (EBMT) consensus recommendations for donor selection in haploidentical hematopoietic cell transplantation |
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| المؤلفون: | Piyanuch Kongtim, Denis-Claude Roy, Fabio Ciceri, Jorge Gayoso, Arnon Nagler, Franco Aversa, Monzr M. Al Malki, Mohamad Mohty, Asad Bashey, Patrick Ben Soussan, Paul O'Donnell, Rizwan Romee, Rupert Handgretinger, Yolande Arnault, Luca Castagna, Leo Luznik, Hillard M. Lazarus, Ephraim J. Fuchs, Bipin N. Savani, Stefan O. Ciurea, Scott D. Solomon, Andrea Bacigalupo, Xiao-Jun Huang, Didier Blaise, Franco Locatelli, Karen K. Ballen, Massimo F. Martelli |
| المساهمون: | Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ciurea, S. O., Al Malki, M. M., Kongtim, P., Fuchs, E. J., Luznik, L., Huang, X. -J., Ciceri, F., Locatelli, F., Aversa, F., Castagna, L., Bacigalupo, A., Martelli, M., Blaise, D., Ben Soussan, P., Arnault, Y., Handgretinger, R., Roy, D. -C., O'Donnell, P. V., Bashey, A., Solomon, S., Romee, R., Gayoso, J., Lazarus, H. M., Ballen, K., Savani, B. N., Mohty, M., Nagler, A. |
| المصدر: | Bone Marrow Transplantation Bone Marrow Transplantation, Nature Publishing Group, 2020, 55 (1), pp.12-24. ⟨10.1038/s41409-019-0499-z⟩ Bone Marrow Transplantation, 2020, 55 (1), pp.12-24. ⟨10.1038/s41409-019-0499-z⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Consensus, Transplantation Conditioning, Cyclophosphamide, medicine.medical_treatment, Graft vs Host Disease, Hematopoietic stem cell transplantation, Disease, Donor Selection, Settore MED/28 - MALATTIE ODONTOSTOMATOLOGICHE, 03 medical and health sciences, blood transplantation, t-cells, EBMT recommendations, 0302 clinical medicine, Bone Marrow, Internal medicine, ABO blood group system, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Transplantation, business.industry, Donor selection, Hematopoietic Stem Cell Transplantation, Hematology, 3. Good health, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, HSCT, [SDV.IMM]Life Sciences [q-bio]/Immunology, Bone marrow, business, 030215 immunology, medicine.drug |
| الوصف: | The number of HLA-haploidentical hematopoietic cell transplants continues to increase worldwide due to recent improvements in outcomes, allowing more patients with hematological malignancies and non-malignant disorders to benefit from this procedure and have a chance to cure their disease. Despite these encouraging results, questions remain as multiple donors are usually available for transplantation, and choosing the best HLA-haploidentical donor for transplantation remains a challenge. Several approaches to haploidentical transplantation havebeen developed over time and, based on the graft received, can be grouped as follows: T-cell depleted haploidentical transplants, either complete or partial, or withT-cell replete grafts, performed with post-transplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis, or G-CSF-primed bone marrow graft and enhanced GVHD prophylaxis. Carefully selecting the donor can help optimize transplant outcomes for recipients of haploidentical donor transplants. Variables usually considered in the donor selection include presence of donor-specific antibodies in the recipient, donor age, donor/recipient gender and ABO combinations, and immunogenic variables, such as natural killer cell alloreactivity or KIR haplotype. Here we provide a comprehensive review of available evidence for selecting haploidentical donors for transplantation, and summarize the recommendations from the European Society for Blood and Marrow Transplantation (EBMT) on donor selection for different transplant platforms. |
| تدمد: | 1476-5365 0268-3369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38516f0733d681adad4d1fe86835af04Test https://doi.org/10.1038/s41409-019-0499-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....38516f0733d681adad4d1fe86835af04 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765365 02683369 |
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