Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism
| العنوان: | Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism |
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| المؤلفون: | Stott, D.J., Rodondi, N., Kearney, P.M., Ford, I., Westendorp, R.G.J., Mooijaart, S.P., Sattar, N., Aubert, C.E., Aujesky, D., Bauer, D.C., Baumgartner, C., Blum, M.R., Browne, J.P., Byrne, S., Collet, T.H., Dekkers, O.M., Elzen, W.P.J. den, Puy, R.S. du, Ellis, G., Feller, M., Floriani, C., Hendry, K., Hurley, C., Jukema, J.W., Kean, S., Kelly, M., Krebs, D., Langhorne, P., McCarthy, G., McCarthy, V., McConnachie, A., McDade, M., Messow, M., O'Flynn, A., O'Riordan, D., Poortvliet, R.K.E., Quinn, T.J., Russell, A., Sinnott, C., Smit, J.W.A., Dorland, H.A. van, Walsh, K.A., Walsh, E.K., Watt, T., Wilson, R., Gussekloo, J., TRUST Study Grp |
| المساهمون: | Sinnott, Carol [0000-0002-8620-7461], Apollo - University of Cambridge Repository |
| المصدر: | The New England Journal of Medicine, 376, 26, pp. 2534-2544 Stott, D J, Rodondi, N, Kearney, P M, Ford, I, Westendorp, R G J, Mooijaart, S P, Sattar, N, Aubert, C E, Aujesky, D, Bauer, D C, Baumgartner, C, Blum, M R, Browne, J P, Byrne, S L, Collet, T-H, Dekkers, O M, den Elzen, W P J, Du Puy, R S, Ellis, G, Feller, M, Floriani, C, Hendry, K, Hurley, C, Jukema, J W, Kean, S, Kelly, M, Krebs, D, Langhorne, P, McCarthy, G, McCarthy, V, McConnachie, A, McDade, M, Messow, M, O’Flynn, A, O’Riordan, D, Poortvliet, R K E, Quinn, T J, Russell, A, Sinnott, C, Smit, J W A, Van Dorland, H A, Walsh, K A, Walsh, E K, Watt, T, Wilson, R, Gussekloo, J & the TRUST Study Group 2017, ' Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism ', New England Journal of Medicine, vol. 376, no. 26, pp. 2534-2544 . https://doi.org/10.1056/NEJMoa1603825Test New England Journal of Medicine, 376(26), 2534-2544 Stott, David J; Rodondi, Nicolas; Kearney, Patricia M; Ford, Ian; Westendorp, Rudi G J; Mooijaart, Simon P; Sattar, Naveed; Aubert, Carole E; Aujesky, Drahomir; Bauer, Douglas C; Baumgartner, Christine; Blum, Manuel R; Browne, John P; Byrne, Stephen; Collet, Tinh-Hai; Dekkers, Olaf M; den Elzen, Wendy P J; Du Puy, Robert S; Ellis, Graham; Feller, Martin; ... (2017). Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. New England journal of medicine NEJM, 376(26), pp. 2534-2544. Massachusetts Medical Society MMS 10.1056/NEJMoa1603825 <http://dx.doi.org/10.1056/NEJMoa1603825Test> The New England Journal of Medicine, 376, 2534-2544 New England Journal of Medicine, vol. 376, no. 26, pp. 2534-2544 |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, endocrine system, medicine.medical_specialty, Pediatrics, endocrine system diseases, medicine.medical_treatment, Levothyroxine, Thyrotropin, General Medicine, 030209 endocrinology & metabolism, Reference range, 610 Medicine & health, 030204 cardiovascular system & hematology, Placebo, law.invention, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, Hypothyroidism, law, 360 Social problems & social services, Subclinical hypothyroidism, medicine, Humans, Treatment Failure, Fatigue, Subclinical infection, Aged, Aged, 80 and over, Intention-to-treat analysis, business.industry, Thyroid, R1, 3. Good health, Intention to Treat Analysis, Clinical trial, Thyroxine, medicine.anatomical_structure, Physical therapy, Quality of Life, Female, Hormone therapy, business, hormones, hormone substitutes, and hormone antagonists, medicine.drug |
| الوصف: | Item does not contain fulltext BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. METHODS: We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter; free thyroxine level within the reference range). A total of 368 patients were assigned to receive levothyroxine (at a starting dose of 50 mug daily, or 25 mug if the body weight was |
| وصف الملف: | application/pdf |
| تدمد: | 0028-4793 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03506b0c89052ddf36b67497c62e2a69Test https://hdl.handle.net/2066/174689Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03506b0c89052ddf36b67497c62e2a69 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00284793 |
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