نتائج البحث - "Lactate dehydrogenase"

1

The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease : an analysis by the Global Germ Cell Tumor Collaborative Group (G3)

المصدر: WORLD JOURNAL OF UROLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
World Journal of Urology

مصطلحات موضوعية: Nephrology, Adult, Male, medicine.medical_specialty, Treatment response, Multivariate analysis, Adolescent, Upper limit of normal, Urology, Gastroenterology, 03 medical and health sciences, Collaborative group, chemistry.chemical_compound, Young Adult, Prognostic markers, 0302 clinical medicine, Testicular Neoplasms, Internal medicine, Lactate dehydrogenase, medicine, Advanced disease, Humans, 030304 developmental biology, Aged, Neoplasm Staging, Retrospective Studies, 0303 health sciences, L-Lactate Dehydrogenase, business.industry, Significant difference, Seminoma, Middle Aged, medicine.disease, Prognosis, Survival Rate, Lactate dehydrogenase, Prognostic markers, Seminoma, Upper limit of normal, chemistry, 030220 oncology & carcinogenesis, Original Article, business

الوصف: Purpose The prognostic significance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defined. We investigated the prognostic impact of LDH levels prior to first-line systemic treatment and other clinical characteristics in this subset of patients. Methods Files from two registry studies and one single-institution database were analyzed retrospectively. Uni- and multivariate analyses were conducted to identify patient characteristics associated with recurrence free survival (RFS), overall survival (OS), and complete response rate (CRR). Results The dataset included 351 metastatic seminoma patients with a median follow-up of 5.36 years. Five-year RFS, OS and CRR were 82%, 89% and 52%, respectively. Explorative analysis revealed a cut-off LDH level of n = 228) vs. ≥ 2.5 ULN (n = 123) to be associated with a significant difference concerning OS associated with 5-years OS rates of 93% vs. 83% (p = 0.001) which was confirmed in multivariate analysis (HR 2.87; p = 0.004). Furthermore, the cut-off LDH p = 0.012) and 32% vs. 59% (p ≤ 0.001), respectively. Conclusions LDH levels correlate with treatment response and survival in metastatic seminoma patients and should be considered for their prognostic stratification.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cdc4dd03ba50e7225a931a8f42e085Test

2

Prognostic model with alkaline phosphatase, lactate dehydrogenase and presence of Gleason pattern 5 for worse overall survival in low-risk metastatic hormone-sensitive prostate cancer

المصدر: Japanese Journal of Clinical Oncology. 51:1665-1671

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Androgen deprivation therapy, 03 medical and health sciences, chemistry.chemical_compound, Prostate cancer, 0302 clinical medicine, Lactate dehydrogenase, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Retrospective Studies, L-Lactate Dehydrogenase, Proportional hazards model, business.industry, Hazard ratio, Prostatic Neoplasms, Androgen Antagonists, Retrospective cohort study, General Medicine, Alkaline Phosphatase, Prognosis, medicine.disease, Hormones, Androgen receptor, Prostatic Neoplasms, Castration-Resistant, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Alkaline phosphatase, business

الوصف: Background Randomized trials showed the survival benefits of the combined use of androgen receptor axis-targeted agents with androgen deprivation therapy in metastatic hormone-sensitive prostate cancer (mHSPC), regardless of the risk. However, treating patients with low-risk mHSPC with such intensive treatment is still debatable. Methods This retrospective study included 155 low-risk patients among 467 mHSPC patients treated in our affiliated institutions. The association between predictive factors and treatment outcomes was estimated using the Kaplan–Meier method and log-rank test. Predictive factors for castration resistant prostate cancer (CRPC)-free survival were investigated using Cox regression analyses. Results During the median follow-up of 39 months, 38.7% of patients developed CRPC and 14.2% died. In the multivariate analyses, a presence of Gleason pattern 5 (hazard ratio [HR] 2.04), high alkaline phosphatase (HR 1.007) and high lactate dehydrogenase (HR 1.009) were significant predictive factors for shorter CRPC-free survival. Finally, 155 patients were stratified into favorable- and unfavorable-risk groups based on the numbers of the predictive factors. The overall survival (OS) in the unfavorable-risk group (total scores: 2–3) was significantly worse than that of the favorable-risk group (total score: 0–1) (P = 0.02). This prognostic model was assessed with 50 low-risk mHSPC patients from the external validation dataset and found both the time to CRPC, and the OS in the unfavorable-risk group was significantly worse than that of the favorable-risk group (P Conclusions The combination of Gleason pattern 5, high alkaline phosphatase and lactate dehydrogenase can predict those with worse OS in low-risk mHSPC patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca64e70eea9e33e609c75690030a9f6Test
https://doi.org/10.1093/jjco/hyab115Test

3

Clinical characteristics of Japanese patients with moderate to severe COVID-19

المصدر: Journal of Infection and Chemotherapy

مصطلحات موضوعية: Male, 0301 basic medicine, Multivariate analysis, BMI, body mass index, Lymphocyte, Disease, Respiratory failure, Severity of Illness Index, 0302 clinical medicine, Japan, FiO2, fraction of inspired oxygen, Medicine, Pharmacology (medical), 030212 general & internal medicine, COVID-19, coronavirus disease 2019, Aged, 80 and over, Medical record, Age Factors, list: AST, aspartate aminotransferase, Middle Aged, SARS-CoV-2, severe acute respiratory syndrome coronavirus2, C-Reactive Protein, Infectious Diseases, medicine.anatomical_structure, CRP, C-reactive protein, Original Article, Female, Adult, Microbiology (medical), medicine.medical_specialty, 030106 microbiology, macromolecular substances, AUC, area under curve, Severity, 03 medical and health sciences, Internal medicine, Severity of illness, Humans, Aspartate Aminotransferases, Lymphocyte Count, Aged, Retrospective Studies, LDH, Lactate dehydrogenase, L-Lactate Dehydrogenase, SARS-CoV-2, business.industry, SpO2, saturation of percutaneous oxygen, COVID-19, Retrospective cohort study, PaO2, pressure of oxygen, ROC, receiver operating characteristic, Coronavirus, business, ECMO, extracorporeal membrane oxygenation, Body mass index

الوصف: Introduction Although several reports on the risk factors for severe disease of COVID-19 already exist, reports on effective early indicators are still limited, especially from Japan. This study was conducted to clarify the patient’s characteristics whose disease progressed to severe status. Methods The medical records of all consecutive 300 Japanese patients hospitalized at our institution between February and November 2020 were retrospectively reviewed. The clinical characteristics were evaluated to compare between mild (no oxygen needed), moderate (oxygen needs of 1–4 L/min), and severe diseases (oxygen needs of 5 L/min or more). Results The median age was 68 years old, with 123 (41.0%) males and 177 (59.0%) females. Of these, 199 patients (66.3%), 55 patients (18.3%), 46 patients (15.3%) patients were in the mild disease, moderate disease, severe disease groups, respectively. Patients with severe disease were more likely to be older, have more comorbidities, and tended to have higher body mass index. In laboratory data, lymphocyte count, levels of C-reactive protein (CRP), LDH, and AST on admission were significantly associated with the severity. In multivariate analysis, age and CRP were the independent risk factors for severe disease (OR = 1.050, 1.130, respectively). The optimal cut-off value for age was 74 years old and that for CRP was 3.15 mg/dL. Conclusions Age and CRP were independently associated with disease severity of COVID-19 in multivariate analysis. Additionally, the numbers of underlying disease, lymphocyte count, and inflammatory markers such as LDH and D-dimer may also be related to disease severity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b469e31a8606cf4ed6c0b34983804c73Test
https://doi.org/10.1016/j.jiac.2021.02.028Test

4

The relationship between serum lactate dehydrogenase level and mortality in critically ill patients

المؤلفون: Gang Wang, Jingjing Zhang, Xuting Jin, Jiajia Ren, Jiamei Li, Ruohan Li, Ya Gao, Dan Su

المصدر: Biomarkers in Medicine. 15:551-559

مصطلحات موضوعية: Male, medicine.medical_specialty, Critical Illness, Clinical Biochemistry, Logistic regression, Risk Assessment, law.invention, Sepsis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, law, Lactate dehydrogenase, Internal medicine, Drug Discovery, medicine, Humans, Hospital Mortality, 030212 general & internal medicine, Lactate Dehydrogenases, Aged, Retrospective Studies, Critically ill, business.industry, Biochemistry (medical), Middle Aged, Prognosis, medicine.disease, Intensive care unit, Survival Rate, Intensive Care Units, chemistry, Quartile, Health evaluation, 030220 oncology & carcinogenesis, Female, business, Biomarkers, Follow-Up Studies, Serum lactate dehydrogenase level

الوصف: Background: To assess the association between serum lactate dehydrogenase (LDH) levels and mortality in intensive care unit patients. Materials & methods: A total of 1981 patients in the eICU Collaborative Research Database were divided into four groups according to quartiles of LDH levels. Logistic regressions were performed. Results: Elevated LDH levels were significantly associated with higher mortality (intensive care unit mortality: Q2 vs Q1: 1.046 [0.622–1.758]; Q3 vs Q1: 1.667 [1.029–2.699]; and Q4 vs Q1: 1.760 [1.092–2.839]). Similar results persisted in patients with different acute physiology and chronic health evaluation IV scores, and with or without sepsis. Conclusion: The serum LDH level may aid in the early identification of mortality risk in critically ill patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b50731bfbf51941c615bc9fad52a69Test
https://doi.org/10.2217/bmm-2020-0671Test

5

Acute Physiological Response to Light- and Heavy-load Power-oriented Exercise in Older Adults

المؤلفون: Jose Losa-Reyna, Aurora Maria Cruz-Santaella, Ignacio Ara, Juan Manuel Carmona-Torres, Robert Csapo, Carlos Rodriguez-Lopez, Julian Alcazar, Luis M. Alegre

المصدر: International Journal of Sports Medicine. 42:1287-1296

الوصف: This study investigated the acute responses to volume-load-matched heavy-load (80% 1RM) versus light-load (40% 1RM) power-oriented resistance training sessions in well-functioning older adults. Using a randomized cross-over design, 15 volunteers completed each condition on a leg press. Neuromuscular (maximal isometric force and rate of force development) and functional performance (power during sit-to-stand test), lactate, and muscle damage biochemistry (creatine kinase, lactate dehydrogenase and C-reactive protein serum concentration) were assessed pre- and post-exercise. Performance declines were found after heavy-load (Cohen's d effect size (d); maximal isometric force=0.95 d; rate of force development=1.17 d; sit-to-stand power =0.38 d, all p0.05) and light-load (maximal isometric force=0.45 d; rate of force development=0.9 d; sit-to-stand power=1.17 d, all p0.05), while lactate concentration increased only after light-load (1.7 d, p=0.001). However, no differences were found between conditions (all p0.05). Both conditions increased creatine kinase the day after exercise (marginal effect=0.75 d, p0.001), but no other blood markers increased (all, p0.05). Irrespective of the load used, power training induced non-clinically significant decreases in sit-to-stand performance, moderate declines in maximal isometric force, but pronounced decreases in the rate of force development. Furthermore, the metabolic stress and muscle damage were minor; both sessions were generally well tolerated by well-functioning older adults without previous experience in resistance training.This study investigated the acute responses to volume-load-matched heavy-load (80% 1RM) versus light-load (40% 1RM) power-oriented resistance training sessions in well-functioning older adults. Using a randomized cross-over design, 15 volunteers completed each condition on a leg press. Neuromuscular (maximal isometric force and rate of force development) and functional performance (power during sit-to-stand test), lactate, and muscle damage biochemistry (creatine kinase, lactate dehydrogenase and C-reactive protein serum concentration) were assessed pre- and post-exercise. Performance declines were found after heavy-load (Cohen’s d effect size (d); maximal isometric force=0.95 d; rate of force development=1.17 d; sit-to-stand power =0.38 d, all p0.05) and light-load (maximal isometric force=0.45 d; rate of force development=0.9 d; sit-to-stand power=1.17 d, all p0.05), while lactate concentration increased only after light-load (1.7 d, p=0.001). However, no differences were found between conditions (all p0.05). Both conditions increased creatine kinase the day after exercise (marginal effect=0.75 d, p0.001), but no other blood markers increased (all, p0.05). Irrespective of the load used, power training induced non-clinically significant decreases in sit-to-stand performance, moderate declines in maximal isometric force, but pronounced decreases in the rate of force development. Furthermore, the metabolic stress and muscle damage were minor; both sessions were generally well tolerated by well-functioning older adults without previous experience in resistance training.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79a18b48117a71a2257e355d45e6f44Test
https://doi.org/10.1055/a-1408-4793Test

6

Biomarkers of Distinguishing Neutrophil-Predominant Tuberculous Pleural Effusion from Parapneumonic Pleural Effusion

المؤلفون: Zeng-hua Ren, Ling Xu

المصدر: The American Journal of the Medical Sciences. 361:469-478

الوصف: Background Tuberculous pleural effusion (TPE) is usually characterized by lymphocytic predominance and high pleural fluid adenosine deaminase (pfADA), while parapneumonic pleural effusion (PPE) is usually characterized by neutrophilic predominance. However, in some cases, neutrophils can be predominant in TPE. In such cases, the differential diagnosis between TPE and PPE is challenging and has been rarely investigated. The aim of this study was to evaluate the accuracy of pfADA, pleural fluid lactate dehydrogenase (pfLDH) and other parameters, such as age/pfADA in the differential diagnosis of neutrophil-predominant TPE (NP-TPE) and PPE. Methods Between January 2003 and August 2018, 19 patients with NP-TPE and 54 patients with PPE at Shanghai Jiao Tong University Affiliated Sixth People's Hospital were retrospectively reviewed. Age, blood and pleural fluid findings, and eight ratios that consisted of routine biomarkers were compared between the two groups in ≤50 and >50 years old groups. ROC curve analysis was used to evaluate diagnostic performance. Results The three parameters with the largest AUC were age/pfADA, pfADA and pfLDH in ≤ 50 years old group, and pfADA, age/pfADA and the percentage of neutrophils in pleural fluid (pfN%) in >50 years old group. For patients ≤ 50 years old, pfADA combined with pfLDH or age/pfADA combined with pfLDH could increase the specificity to 100%, while the sensitivity of the former was high (84.6% vs 76.9%). For patients >50 years old, both pfADA combined with pfN% and age/pfADA combined with pfN% could increase the specificity to 90.3% with the same sensitivity. Conclusions Although pfADA played an important role in the discrimination of NP-TPE from PPE, combining pfADA with pfLDH for patients ≤50 years old or combining pfADA with pfN% for patients >50 years old might improve diagnostic performance.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8919d22e7f4352526b8614c03564b6Test
https://doi.org/10.1016/j.amjms.2020.10.015Test

7

Downregulation of type III interferons in patients with severe COVID‐19

المؤلفون: Shin Ohta, Fukuda Yosuke, Mayumi Yamamoto, Hideki Inoue, Hironori Sagara, Tomoyuki Kimura, Shintaro Suzuki, Yoko Sato, Akihiko Tanaka, Yuiko Goto, Tetsuya Homma, Sojiro Kusumoto, Chisato Onitsuka, Kuniaki Hirai, Hitoshi Ikeda

المصدر: Journal of Medical Virology

مصطلحات موضوعية: Male, Chemokine, medicine.medical_treatment, Gastroenterology, Severity of Illness Index, SARS‐CoV‐2, Interferon Lambda, chemistry.chemical_compound, 0302 clinical medicine, cytokine, 030212 general & internal medicine, biology, Pulmonary Surfactant-Associated Protein A, Interleukin, Middle Aged, Pulmonary Surfactant-Associated Protein D, Pathophysiology, Infectious Diseases, Cytokine, C-Reactive Protein, 030211 gastroenterology & hepatology, Female, Chemokines, Adult, medicine.medical_specialty, Short Communication, Short Communications, Down-Regulation, macromolecular substances, type III interferon, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, COVID‐19, Virology, Internal medicine, Lactate dehydrogenase, Severity of illness, medicine, Humans, Aged, L-Lactate Dehydrogenase, business.industry, SARS-CoV-2, Interleukins, C-reactive protein, chemokine, Mucin-1, COVID-19, Fibrinogen, Ferritin, IFN‐lambda, chemistry, Ferritins, biology.protein, Interferons, business

الوصف: Coronavirus disease 2019 (COVID‐19) is globally rampant, and to curb the growing burden of this disease, in‐depth knowledge about its pathophysiology is needed. This was an observational study conducted at a single center to investigate serum cytokine and chemokine levels of COVID‐19 patients, based on disease severity. We included 72 consecutive COVID‐19 patients admitted to our hospital from March 21 to August 31, 2020. Patients were divided into Mild‐Moderate I (mild) and Moderate II‐Severe (severe) groups based on the COVID‐19 severity classification developed by the Ministry of Health, Labor and Welfare (MHLW) of Japan. We compared the patient characteristics as well as the serum cytokine and chemokine levels on the day of admission between the two groups. Our findings indicated that the severe group had significantly higher levels of serum fibrinogen, d‐dimer, lactate dehydrogenase, C‐reactive protein, ferritin, Krebs von den Lungen‐6, surfactant protein (SP)‐D, and SP‐A than the mild group. Strikingly, the levels of interleukin (IL)‐28A/interferon (IFN)‐λ2 were significantly lower in the severe group than in the mild group. We believe that reduced levels of type III interferons (IFN‐λs) and alterations in the levels of other cytokines and chemokines may impact the severity of the disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd1d96207bef0b407a84b8214aabe72Test
http://europepmc.org/articles/PMC8250710Test

8

Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice

المؤلفون: Mohamed K. Abdel-Rafei, Noura M Thabet, Nermeen M El Bakary, Ghada El Tawill, Khaled Shaaban Azab, Neama M El Fatih

المصدر: Journal of Radiation Research

مصطلحات موضوعية: Necrosis, Antioxidant, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Fucoxanthin, Xanthophylls, Kidney, Antioxidants, chemistry.chemical_compound, Mice, 0302 clinical medicine, chemistry.chemical_classification, 0303 health sciences, Apelin Receptors, Radiation, Glutathione peroxidase, NF-kappa B, Apelin-13/APJ, Malondialdehyde, Oxidants, Apelin, medicine.anatomical_structure, Liver, Matrix Metalloproteinase 9, Organ Specificity, 030220 oncology & carcinogenesis, Intercellular Signaling Peptides and Proteins, Matrix Metalloproteinase 2, medicine.symptom, MMP-9, Whole-Body Irradiation, Signal Transduction, medicine.medical_specialty, α-7nAchR, 03 medical and health sciences, Lactate dehydrogenase, Internal medicine, medicine, Animals, Radiology, Nuclear Medicine and imaging, Fundamental Radiation Science, 030304 developmental biology, Inflammation, Tissue Inhibitor of Metalloproteinase-1, L-Lactate Dehydrogenase, Monocyte, Glutathione, γ-radiation, Endocrinology, chemistry, Gamma Rays, AcademicSubjects/SCI00960, AcademicSubjects/MED00870

الوصف: Apelin-13 and APJ are implicated in different key physiological processes. This work aims at exploring the radioprotective effect of fucoxanthin (FX) on γ-radiation (RAD)-induced changes in the apelin-13/APJ pathway, which causes damage in the liver, kidney, lung and spleen of mice. Mice were administered FX (10 mg kg–1 day–1, i.p) and exposed to γ-radiation (2.5 Gy week–1) for four consecutive weeks. The treatment of irradiated mice by FX resulted in a significant amendment in protein expression of the apelin-13/APJ/NF-κB signalling pathway concurrently with reduced hypoxia (hypoxia-inducible factor-1α), suppressed oxidative stress marker (malondialdehyde), enhanced antioxidant defence mechanisms (reduced glutathione and glutathione peroxidase), a modulated inflammatory response [interleukin-6 (IL-6), monocyte chemoattractant protein-1, IL-10 and α-7-nicotinic acetylcholine receptor) and ameliorated angiogenic regulators [matrix metalloproteinase (MMP-2), MMP-9 and tissue inhibitor of metalloproteinase-1), as well as the tissue damage indicator (lactate dehydrogenase) in organ tissues. In addition, there were significant improvement in serum inflammatory markers tumour necrosis factor-α, IL-10, IL-1β and C-reactive protein compared with irradiated mice. The histopathological investigation of the FX + RAD organ tissues support the biochemical findings where the improvements in the tissues’ architecture were obvious when compared with those of RAD. FX was thus shown to have a noticeable radioprotective action mediated through its regulatory effect on the apelin-13/APJ/NF-κB signalling pathway attributed to its antioxidant and anti-inflammatory activity that was reflected in different physiological processes. It could be recommended to use FX in cases of radiation exposure to protect normal tissues.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30214c17e6d8f3108e2b41351abd16bTest
http://europepmc.org/articles/PMC8273792Test

9

LDH, CRP and ALB predict nucleic acid turn negative within 14 days in symptomatic patients with COVID-19

المؤلفون: Gaoli Liu, Bicheng Zhang, TingTing Liu, Haifeng Hu, Shaowen Zhang

المصدر: Scottish Medical Journal

مصطلحات موضوعية: Male, medicine.medical_specialty, Time Factors, Coronavirus disease 2019 (COVID-19), Serum albumin, Gastroenterology, Procalcitonin, Turn (biochemistry), 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Lactate dehydrogenase, medicine, Humans, AST, Serum Albumin, Retrospective Studies, 030304 developmental biology, 0303 health sciences, L-Lactate Dehydrogenase, biology, SARS-CoV-2, business.industry, C-reactive protein, quarantine, COVID-19, lactate dehydrogenase, Original Articles, General Medicine, Middle Aged, Prognosis, C-Reactive Protein, ROC Curve, chemistry, 030220 oncology & carcinogenesis, Predictive value of tests, DNA, Viral, biology.protein, Nucleic acid, Female, business, procalcitonin, Biomarkers

الوصف: Aims To search for biochemical indicators that can identify symptomatic patients with COVID-19 whose nucleic acid could turn negative within 14 days, and assess the prognostic value of these biochemical indicators in patients with COVID-19. Patients and methods We collected the clinical data of patients with COVID-19 admitted to our hospital, by using logistic regression analysis and AUC curves, explored the relationship between biochemical indicators and nucleic acid positive duration, the severity of COVID-19, and hospital stay respectively. Results A total of two hundred and thirty-three patients with COVID-19 were enrolled in the study. We found patients whose nucleic acid turned negative within 14 days had lower LDH, CRP and higher ALB ( P 31days with statistical significance ( P 35.8 g/L) was about 4 times higher than that in patients with high LDH, CRP and low ALB ( P Conclusions LDH, CRP and ALB are useful prognostic marker for predicting nucleic acid turn negative within 14 days in symptomatic patients with COVID-19.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4299d9918d60277414ad53776c733b56Test
https://doi.org/10.1177/0036933021994243Test

10

Prognostic Analysis of Patients with Primary Extranodal Lymphoma: A Retrospective Study

المؤلفون: Yanqiu Xu, Feng Zhu, Linyan Xu, Lingling Jiang, Lingling Yin, Kailin Xu, Zhenyu Li, Xiaohui Fan, Hanying Shen, Linlin Nie, Jieyun Xia

المصدر: Cancer Management and Research

الوصف: Hanying Shen,1 Lingling Jiang,1 Linlin Nie,1 Xiaohui Fan,1 Yanqiu Xu,1 Lingling Yin,2 Linyan Xu,1,3 Jieyun Xia,2 Zhenyu Li,1– 3 Feng Zhu,1– 3 Kailin Xu1– 3 1Blood Disease Institute, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People’s Republic of China; 2Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, People’s Republic of China; 3Key Laboratory of Bone Marrow Stem Cell, Xuzhou, Jiangsu, 221000, People’s Republic of ChinaCorrespondence: Feng Zhu; Jieyun XiaDepartment of Hematology, The Affiliated Hospital of Xuzhou Medical University, 99, West Huaihai Road, Quanshan District, Xuzhou, Jiangsu, 221002, People’s Republic of ChinaTel +86 516 8580 6985Fax +86 516 8580 1527Email frankfeng_2004@126.com; jieyunxia0315@163.comBackground: Originating from extranodal organs or tissues, primary extranodal lymphoma (PENL) acts in different primary sites with diverse clinical performances and PENL has remarkable geographical differences and lacks the relevant reports in each region.Patients and Methods: Two hundred and twenty PENL patients were enrolled, and the relevant clinical and laboratory indicators were analyzed. In addition, statistical methods were applied to analyze the effects of different factors on overall survival (OS) and progression-free survival (PFS) of patients.Results: The three most frequent primary sites of PENL are the digestive system, head and neck, and central nervous system. The patients were classified into groups based on their risk status, resulting in low-risk, medium-low-risk, medium-high-risk, and high-risk, and their respective 3-year OS values were calculated, which showed that 121 patients (55%) were in the low-risk group and 3-year OS was 85.2% (25.9% medium-low-risk, 3-year OS 66.6%; 15% medium-high-risk, 3-year OS 61.9%; 4.09% high risk, 3-year OS 45.7%). A multivariate analysis of the Cox regression demonstrated that serum beta 2-microglobulin (β2-MG) and lactate dehydrogenase (LDH) were independent prognostic factors for OS and PFS, respectively. Both the performance status and pathological subtypes were independent prognostic factors for OS and PFS.Conclusion: The correlated independent risk factors such as β2-MG, LDH, performance status, and pathological subtypes, were helpful for effectively determining the prognosis of PENL patients and guiding treatment.Keywords: beta 2-microglobulin, lactate dehydrogenase, performance status, pathological subtype, primary extranodal lymphoma, prognostic analysis

وصف الملف: text/html

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28afac9368d1f26eb8e371cac632c347Test
https://doi.org/10.2147/cmar.s299745Test

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