PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action
| العنوان: | PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action |
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| المؤلفون: | Miguel Hernandez-Quiles, Marjoleine F. Broekema, Eric Kalkhoven |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cell type, Endocrinology, Diabetes and Metabolism, PPARy, Peroxisome proliferator-activated receptor, mechanism, Review, Biology, adipocyte, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Transactivation, 0302 clinical medicine, Immune system, Endocrinology, Neoplasms, Adipocytes, Animals, Humans, Receptor, Transcription factor, cancer cell, chemistry.chemical_classification, lcsh:RC648-665, PPAR gamma, 030104 developmental biology, chemistry, Nuclear receptor, 030220 oncology & carcinogenesis, Immune System, Cancer cell, Cancer research, immune cell, Energy Metabolism |
| الوصف: | The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, is one of the most extensively studied ligand-inducible transcription factors. Since its identification in the early 1990s, PPARγ is best known for its critical role in adipocyte differentiation, maintenance, and function. Emerging evidence indicates that PPARγ is also important for the maturation and function of various immune system-related cell types, such as monocytes/macrophages, dendritic cells, and lymphocytes. Furthermore, PPARγ controls cell proliferation in various other tissues and organs, including colon, breast, prostate, and bladder, and dysregulation of PPARγ signaling is linked to tumor development in these organs. Recent studies have shed new light on PPARγ (dys)function in these three biological settings, showing unified and diverse mechanisms of action. Classical transactivation—where PPARγ activates genes upon binding to PPAR response elements as a heterodimer with RXRα—is important in all three settings, as underscored by natural loss-of-function mutations in FPLD3 and loss- and gain-of-function mutations in tumors. Transrepression—where PPARγ alters gene expression independent of DNA binding—is particularly relevant in immune cells. Interestingly, gene translocations resulting in fusion of PPARγ with other gene products, which are unique to specific carcinomas, present a third mode of action, as they potentially alter PPARγ’s target gene profile. Improved understanding of the molecular mechanism underlying PPARγ activity in the complex regulatory networks in metabolism, cancer, and inflammation may help to define novel potential therapeutic strategies for prevention and treatment of obesity, diabetes, or cancer. |
| اللغة: | English |
| تدمد: | 1664-2392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc853f4e4efe7a547478c12fd25c01e5Test http://europepmc.org/articles/PMC7953066Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bc853f4e4efe7a547478c12fd25c01e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
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