Treatment of hypertension in obese patients: focus on telmisartan
| العنوان: | Treatment of hypertension in obese patients: focus on telmisartan |
|---|---|
| المؤلفون: | I. E. Deneka, A. V. Rodionov, V. V. Fomin |
| المصدر: | Кардиоваскулярная терапия и профилактика, Vol 17, Iss 6, Pp 69-76 (2018) |
| بيانات النشر: | «SILICEA-POLIGRAF» LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Angiotensin receptor, arterial hypertension, obesity, Adipose tissue, 030204 cardiovascular system & hematology, Pharmacology, Carbohydrate metabolism, telmisartan, metabolic syndrome, 03 medical and health sciences, 0302 clinical medicine, medicine, Diseases of the circulatory (Cardiovascular) system, 030212 general & internal medicine, Receptor, Adiponectin, adiponectin, business.industry, medicine.disease, Obesity, ppary, RC666-701, Telmisartan, Metabolic syndrome, Cardiology and Cardiovascular Medicine, business, medicine.drug |
| الوصف: | The article discusses the role of telmisartan in the treatment of arterial hypertension in patients with metabolic syndrome. Telmisartan is second-generation type 1 angiotensin II receptor blocker, which has unique pleiotropic effects due to partial affinity for receptors that activate the proliferation of subtype y peroxisomes (PPARy) located in adipose tissue. The interrelation of metaflamation, a specific chronic inflammatory process with pathogenetic mechanisms of development of cardiovascular diseases, including arterial hypertension, is also described in study. The role of the adiponectin peptide is considered, which synthesis is stimulated by partial PPARy receptor agonists (as mentioned above — telmisartan). It has a positive effect on fat and carbohydrate metabolism, as well as cardioprotective properties. The conclusion contains the results of numerous randomized studies and meta-analyzes confirming the high efficacy of telmisartan in the treatment of arterial hypertension in patients with morbid obesity. |
| اللغة: | Russian |
| تدمد: | 2619-0125 1728-8800 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d856056ee6c2701c5c347cc20ee683Test https://cardiovascular.elpub.ru/jour/article/view/1286Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b3d856056ee6c2701c5c347cc20ee683 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26190125 17288800 |
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