المؤلفون: Sujit Mukherjee, Evangelos Triantafyllou, Oltin T Pop, Fabien Zoulim, Enes Tunc, Alberto Quaglia, Arjuna Singanayagam, Wafa Khamri, Mark Thursz, Tie Zheng Hou, Fanny Lebossé, Julia Wendon, Rooshi Nathwani, Charalambos G. Antoniades, Cathrin Gudd, Naveenta Kumar, A. Dhar

المساهمون: Imperial College London, King‘s College London, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University College of London [London] (UCL), Manship, Brigitte, BRC ITMAT Funding Scheme, Medical Research Council

المصدر: EBioMedicine
EBioMedicine, 2019, 49, pp.258-268. ⟨10.1016/j.ebiom.2019.10.011⟩

مصطلحات موضوعية: CHRONIC LIVER-FAILURE, 0301 basic medicine, Liver Cirrhosis, Male, Cirrhosis, Research paper, Transcription, Genetic, Apoptosis, Research & Experimental Medicine, CD8-Positive T-Lymphocytes, Chronic liver disease, Severity of Illness Index, 0302 clinical medicine, INFECTION, Ascites, Cytotoxic T cell, Myeloid Cells, CD8(+)T cells, ALD, alcohol-related liver disease, NEUTROPHILS, CD8(+) T cells, medicine.diagnostic_test, ACLF, acute-on-chronic-liver disease, General Medicine, Middle Aged, 3. Good health, CD8+T cells, Phenotype, Treatment Outcome, Medicine, Research & Experimental, 030220 oncology & carcinogenesis, SURVIVAL, CLD, Chronic liver disease, Female, Disease Susceptibility, medicine.symptom, Peritoneum, Life Sciences & Biomedicine, EXPRESSION, CAID, cirrhosis-associated immune dysfunction, NASH, non-alcoholic steatohepatitis, Cirrhosis-associated immune dysfunction, [SDV.CAN]Life Sciences [q-bio]/Cancer, AAH, acute alcoholic hepatitis, Peripheral blood mononuclear cell, General Biochemistry, Genetics and Molecular Biology, Flow cytometry, 03 medical and health sciences, Medicine, General & Internal, Immune system, [SDV.CAN] Life Sciences [q-bio]/Cancer, General & Internal Medicine, medicine, HV, Healthy volunteers, Humans, Aged, Cell Proliferation, Inflammation, Science & Technology, business.industry, ELD, End-stage-liver diseases, HLA-DR Antigens, medicine.disease, AD, acute decompensation, 030104 developmental biology, Immunology, Natural Killer T-Cells, business, CD8, Biomarkers, PMNs, polymorphonuclear neutrophils

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9318081e284f95b31ce34f205764d8dbTest
http://europepmc.org/articles/PMC6945243Test

المؤلفون: Valentin A. Pavlov

المصدر: Pharmacology & Therapeutics

مصطلحات موضوعية: 0301 basic medicine, ChAT, choline acetyltransferase, BMI, body mass index, Inflammatory reflex, NLRP3, NLRs nucleotide-binding oligomerization domain (NOD)-like receptors nucleotide-binding oligomerization domain-like receptor family pyrin domain containing-3, Type 2 diabetes, Disease, Bioinformatics, 0302 clinical medicine, AChE, acetylcholinesterase, Medicine, Pharmacology (medical), TLR, toll-like receptors, NF-κB, nuclear factor kappa B, COVID-19, coronavirus disease 2019, TNF, tumor necrosis factor, IBD, inflammatory bowel disease, HDL-C, high density lipoprotein-cholesterol, Vagus Nerve, GI, gastrointestinal, Metabolic syndrome, ICU, intensive care unit, Bioelectronic medicine, VNS, vagus nerve stimulation, 030220 oncology & carcinogenesis, LPS, lipopolysaccharide, MetS, metabolic syndrome, medicine.symptom, SARS-CoV, severe acute respiratory syndrome CoV, NAFLD, non-alcoholic fatty liver disease, NASH, non-alcoholic steatohepatitis, α7nAChR, alpha 7 nicotinic acetylcholine receptor, Inflammation, HRV, heart rate variability, Article, 03 medical and health sciences, NTS, nucleus tractus solitarius, Immune system, DMN, dorsal motor nucleus of the vagus, Humans, Obesity, mAChR, muscarinic acetylcholine receptor, ARDS, acute respiratory distress syndrome, Pharmacology, SARS-CoV-2, ACh, acetylcholine, business.industry, COVID-19, medicine.disease, NA, nucleus ambiguus, IL, interleukin, Vagus nerve, The inflammatory reflex, 030104 developmental biology, MERS-CoV, Middle East respiratory syndrome corona virus, JAK2/STAT3, Janus kinase 2/signal transducer and activator of transcription 3, business, SARS-CoV-2, severe acute respiratory syndrome coronavirus-2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e3679f48f885bb324216f0c362acfbTest

المؤلفون: Miguel López, Rubén Nogueiras, Xabier Buqué, Maria J. Gonzalez-Rellan, Daniel Beiroa, Patricia Aspichueta, Uxia Fernandez, Begoña Porteiro, Rosalía Gallego, Carlos Dieguez, Guadalupe Sabio, Marcos F. Fondevila, Johan Fernø, Ana Senra, Alfonso Mora

المساهمون: Ministerio de Economía y Competitividad (España), Xunta de Galicia (España), Heise Vest RHF, Comunidad de Madrid (España), Basque Government (España), Fundación AstraZeneca, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Unión Europea. Comisión Europea, Centro de Investigación Biomedica en Red - CIBER

المصدر: Molecular Metabolism, Vol 8, Iss, Pp 132-143 (2018)
Molecular Metabolism
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, pIRE, Inositol-requiring enzyme 1 α, pJNK, phospho c-Jun N-terminal kinase, ACC, acetyl-CoA carboxylase, AST, aspartate aminotransferase, XBP1s, X-box binding protein 1, Abcd1, ATP binding cassette subfamily D member 1, Pharmacology, ER stress, endoplasmic reticulum stress, NFκβ, nuclear factor kappa b, FA, free fatty acid, Mice, Liver disease, UPR, unfolded protein response, 0302 clinical medicine, HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, DG, diacylglycerol, Topoisomerase II Inhibitors, IL6, initerleukin 6, Beta oxidation, Acadm, acyl-CoA deshydrogenase, medium chain, GFP, green fluorescent protein, IL10, interleukin 10, Acox, acyl-CoA oxidase 1, TG, triglyceride, Ad, adenovirus, Hep G2 Cells, Acadl, acyl-CoA deshydrogenase, long-chain, i.p., intraperitoneal, FAS, fatty acid synthase, 3. Good health, Liver, Pparα, peroxisome proliferator activated receptor alpha, JNK, c-Jun N-terminal kinase, Lipogenesis, DOX, Doxorubicin, DN, dominant negative, Original Article, ApoB, apolipoprotein b, Quer, quercetin, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, ASM, acid-soluble metabolites, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, GAPDH, glyceraldehyde-3-phosphate deshydrogenase, AUC, area under curve, Diet, High-Fat, Cell Line, SPF, specific pathogen free room, 03 medical and health sciences, GTT, glucose test tolerance, ALT, alanine aminotransferase, AAV8, adeno-associated virus serotype 8, medicine, Animals, Humans, Obesity, EC, sterified cholesterol, lcsh:RC31-1245, Molecular Biology, MCD, methionine-choline deficient diet, CHOP, C/EBP-homologous protein, Inflammation, business.industry, OA, oleic acid, Lipid metabolism, DIO, diet-induced obesity, Cell Biology, Lipid Metabolism, medicine.disease, CDHFD, choline-deficient high fat diet, Mice, Inbred C57BL, 030104 developmental biology, Doxorubicin, pACC, phospho acetyl-CoA carboxylase, Hepatic stellate cell, BSA, bovine serum albumin, Tumor Suppressor Protein p53, Steatohepatitis, Steatosis, business, Fatp2, solute carrier family 27 (fatty acid transporter) member 2, IL1β, interleukin 1beta, 030217 neurology & neurosurgery, ITT, insulin test tolerance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7642e1971aebb46c881386960e7affTest
http://www.sciencedirect.com/science/article/pii/S2212877817310116Test

المؤلفون: Ina Bergheim, Finn Jung, Anika Nier, Cheng Jun Jin, Annette Brandt, Anja Baumann, José C. Fernández-Checa, Vicent Ribas, Carmen García-Ruiz

المساهمون: Federal Ministry of Education and Research (Germany), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Instituto de Salud Carlos III, Fundación BBVA, University of Vienna

المصدر: Redox Biology
Redox Biology, Vol 21, Iss, Pp-(2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: 0301 basic medicine, Ir, insulin receptor, Tlr, toll-like receptor, Clinical Biochemistry, Ppia, peptidylprolyl isomerase A, DCE, decaffeinated coffee effect, DExDCE, interaction between diet and decaffeinated coffee, Biochemistry, Coffee, chemistry.chemical_compound, ZO-1, zonula occludens-1, Mice, 0302 clinical medicine, PCR, polymerase chain reaction, Coffees, Non-alcoholic Fatty Liver Disease, 3-NT, 3-nitrotyrosine, Intestinal Mucosa, DeCaf, decaffeinated coffee, lcsh:QH301-705.5, Barrier function, ANOVA, analysis of variance, lcsh:R5-920, NAS, NAFLD activity score, Atf, activating transcription factor 6, Fatty liver, Lbp, lipopolysaccharide binding protein, FFC, fat-, fructose- and cholesterol-rich diet, Endoplasmic Reticulum Stress, Immunohistochemistry, iNOS, medicine.anatomical_structure, Pdi, protein disulfide isomerase, Liver, GTT, glucose tolerance test, Female, medicine.symptom, lcsh:Medicine (General), Grp78, 78 kDa glucose-regulated protein, Research Paper, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, Inflammation, Il, interleukin, Intestinal permeability, Nitric Oxide, Permeability, Nitric oxide, 03 medical and health sciences, Insulin resistance, Internal medicine, medicine, Animals, DE, diet effect, Irs, insulin receptor substrate, C, control, Edem1, ER degradation-enhancing alpha-mannosidase-like 1, iNOS, inducible NO-synthase, NO, nitric oxide, business.industry, Organic Chemistry, Chop, C/EBP homologous protein, Feeding Behavior, medicine.disease, Small intestine, Toll-Like Receptor 4, 030104 developmental biology, Endocrinology, Glucose, chemistry, lcsh:Biology (General), Dnajc3, DnaJ homolog subfamily C member 3, ER, endoplasmatic reticulum, Lipid Peroxidation, Steatohepatitis, business, Herpud1, homocysteine-responsive endoplasmatic reticulum-resident ubiquitin-like domain member 1 protein, 030217 neurology & neurosurgery, Biomarkers, Xbp1, X-box binding protein 1

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b173ea7738b5f0fbb2100e259fb20393Test
https://hdl.handle.net/11353/10.1172206Test

المؤلفون: Syeda S. Hasnain, Pousette Hamid, Cesar A. Peralta, Pierre S. Maximus, Zeina Al Achkar

المصدر: Cytokine

مصطلحات موضوعية: 0301 basic medicine, BCL-2, B cell lymphoma 2, Adipose tissue, HOMA2-IR, Homeostatic model assessment- insulin resistance, IGF-1, Insulin-like Growth Factor 1, Disease, Pathogenesis, AMPA, Amino propionic acid receptors, Bioinformatics, Biochemistry, HOMA2-%β, Homeostatic model assessment- β, Energy homeostasis, HDL-C, High-density lipoprotein cholesterol, RBP4, Retinol binding protein 4, 0302 clinical medicine, CL-2, Chemokine ligand 2, c-AMP, Cyclic adenosine monophosphate, Immunology and Allergy, Medicine, CTRP-3, C1q TNF related protein 3, TLR-4, Toll-like receptor 4, TNF-α, Tumor necrosis factor alpha, Adipocytokines, AIS, Adolescent idiopathic scoliosis, STAT, Signal transducer and activator of transcription proteins, EPC, Endothelial progenitor cells, NAFLD, Non-alcoholic fatty liver disease, Hematology, VEGF, Vascular endothelial growth factor, NPY, Neuropeptide Y, LDL-C, Low-density lipoprotein cholesterol, Immunoinflammatory, IL-12, Interleukin 12, Adipose Tissue, 030220 oncology & carcinogenesis, IL-6, Interleukin 6, CRP, C-reactive protein, IL-1β, Interleukin 1β, MMP/TIMP, Matrix metalloproteinase to tissue inhibitor of metalloproteinase balance, medicine.symptom, Inflammation Mediators, CCL-4, Chemokine ligand 4, JAK, Janus kinase, MCP-1, Monocyte chemoattractant protein 1, MMP, Matrix metalloproteinase, FABP-4, Fatty acid-binding protein 4, Immunology, Adipokine, CRF, Chronic renal failure, Inflammation, Muscle disorder, APO-B, Apolipoprotein B, Article, Protective effect, 03 medical and health sciences, IL-8, Interleukin 8, IVDD, Intervertebral disc degeneration, Adipokines, Diabetes mellitus, AMPK, Adenosine monophosphate-activated protein kinase, Animals, Humans, Molecular Biology, A β, Amyloid β, NASH, Non-alcoholic steatohepatitis, Disease progression, ACPA, Anti-citrullinated protein/peptide antibody, business.industry, PAH, Pulmonary artery hypertension, Immunity, mTOR, Mammalian target of rapamycin, medicine.disease, IPAH, Idiopathic pulmonary arterial hypertension, IL-1, Interleukin 1, CKD, Chronic kidney disease, 030104 developmental biology, NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells, PAI-1, Plasminogen activator inhibitor 1, SERCA, Sarcoplasmic/endoplasmic reticulum calcium, business, sVCAM-1, Soluble vascular cell adhesion molecule 1, AdipoR 1&2, Adiponectin receptor 1 & 2, CAP-1, Cyclase-associated protein 1, FGF, Fibroblast growth factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d016dafd0b05db8d4a053f5724d3877fTest
http://europepmc.org/articles/PMC7297161Test