Differences in HIV Markers between Infected Individuals Treated with Different ART Regimens: Implications for the Persistence of Viral Reservoirs
| العنوان: | Differences in HIV Markers between Infected Individuals Treated with Different ART Regimens: Implications for the Persistence of Viral Reservoirs |
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| المؤلفون: | Ben Berkhout, Alexander O. Pasternak, Gilles Darcis |
| المصدر: | Viruses, Vol 12, Iss 489, p 489 (2020) Viruses |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Anti-HIV Agents, antiretroviral therapy, Human immunodeficiency virus (HIV), lcsh:QR1-502, Viremia, Antiretroviral drug, HIV Infections, Review, medicine.disease_cause, lcsh:Microbiology, Persistence (computer science), 03 medical and health sciences, 0302 clinical medicine, Immune system, Acquired immunodeficiency syndrome (AIDS), Virology, Antiretroviral Therapy, Highly Active, Medicine, Animals, Humans, 030212 general & internal medicine, business.industry, virus diseases, HIV, medicine.disease, Antiretroviral therapy, Virus Latency, 030104 developmental biology, Infectious Diseases, Treatment Outcome, residual viremia, Viral replication, Immunology, HIV-1, latent reservoirs, business |
| الوصف: | In adherent individuals, antiretroviral therapy (ART) suppresses HIV replication, restores immune function, and prevents the development of AIDS. However, ART is not curative and has to be followed lifelong. Persistence of viral reservoirs forms the major obstacle to an HIV cure. HIV latent reservoirs persist primarily by cell longevity and proliferation, but replenishment by residual virus replication despite ART has been proposed as another potential mechanism of HIV persistence. It is a matter of debate whether different ART regimens are equally potent in suppressing HIV replication. Here, we summarized the current knowledge on the role of ART regimens in HIV persistence, focusing on differences in residual plasma viremia and other virological markers of the HIV reservoir between infected individuals treated with combination ART composed of different antiretroviral drug classes. |
| اللغة: | English |
| تدمد: | 1999-4915 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83609a98d992618860e9ee7cdec2af1Test https://www.mdpi.com/1999-4915/12/5/489Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b83609a98d992618860e9ee7cdec2af1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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