المؤلفون: Luigi Cristiano

المصدر: Genes & Diseases. 9:941-958

مصطلحات موضوعية: 0301 basic medicine, Pseudogene, EEF1A2, EEF1B2, Translation (biology), Cell Biology, Computational biology, Biology, EEF2, Biochemistry, Eukaryotic translation elongation factor 1 alpha 1, Elongation factor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Eukaryotic translation, 030220 oncology & carcinogenesis, Molecular Biology, Genetics (clinical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4901ab7fd56c3f23002791c86069fd2eTest
https://doi.org/10.1016/j.gendis.2021.03.009Test

المؤلفون: Yongxiang Shen, Rongfeng Da, Huaiying Peng, Xiaomei Guo, Yunhua Liu, Aihua Tian

المصدر: Cancer Biotherapy and Radiopharmaceuticals. 37:927-938

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Cancer Research, Gene knockdown, Cell growth, General Medicine, Biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Real-time polymerase chain reaction, Oncology, Growth factor receptor, Downregulation and upregulation, 030220 oncology & carcinogenesis, microRNA, Cancer research, Gene silencing, Radiology, Nuclear Medicine and imaging, Insulin-like growth factor 1 receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f779d1c4594092fa4e1139b2495559Test
https://doi.org/10.1089/cbr.2020.3671Test

المؤلفون: Grace Mallett, Stephanie Laba, Shoba Amarnath

المصدر: Seminars in Cancer Biology. 86:1045-1055

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_treatment, T cell, Programmed Cell Death 1 Receptor, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, Biology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Neoplasms, Tumor Microenvironment, medicine, Humans, Cytotoxic T cell, Lymphocytes, Tumor microenvironment, Innate lymphoid cell, Immunotherapy, T helper cell, biochemical phenomena, metabolism, and nutrition, Immunity, Innate, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, bacteria, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8244f25e3fec9d119833a987d9b3cd41Test
https://doi.org/10.1016/j.semcancer.2021.05.022Test

المؤلفون: Sen Sheng, Xinyu Nie, Qiaofeng Nan, Shufen Huo, Li Sun, Yingxuan Tian, Min Yu, Fuqiang Liu, Jinglong Gao, Jiao Yu, Yi Liu

المصدر: Cancer Biotherapy and Radiopharmaceuticals. 37:560-568

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Lung Neoplasms, Vesicle-Associated Membrane Protein 1, Biology, medicine.disease_cause, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Circular RNA, Carcinoma, Non-Small-Cell Lung, microRNA, medicine, Humans, Gene Regulatory Networks, Radiology, Nuclear Medicine and imaging, RNA, Messenger, Epidermal growth factor receptor, Gene, Pharmacology, Mutation, Competing endogenous RNA, RNA, Circular, General Medicine, Long non-coding RNA, ErbB Receptors, MicroRNAs, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, RNA, Long Noncoding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a4edd5f822b747739c4cb1fa6c87d6Test
https://doi.org/10.1089/cbr.2020.4049Test

المؤلفون: Nicole Bilek, Violaine Saint-André, Elisa Nemes, Stanley Kimbung Mbandi, Elizabeth Filander, Munyaradzi Musvosvi, Humphrey Mulenga, Matthew L. Albert, Alba Llibre, Vincent Rouilly, Hadn Africa, Céline Posseme, Simba Mabwe, Nikaïa Smith, Vincent Bondet, Thomas J. Scriba, Pierre Bost, Darragh Duffy, Bruno Charbit

المساهمون: Immunologie Translationnelle - Translational Immunology lab, Institut Pasteur [Paris] (IP), Datactix, University of Cape Town, Ecole Doctorale Complexité du Vivant (ED515), Sorbonne Université (SU), Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Département de Biologie Computationnelle - Department of Computational Biology, Insitro [San Francisco], This study was funded by the Bill and Melinda Gates Foundation (OPP1114368 and OPP1204624), with additional support from the French Government’s Investissement d’Avenir Program, Laboratoire d’Excellence 'Milieu Intérieur' Grant ANR-10-LABX-69-01. AL was supported by the Fondation Recherche Médicale (SPF20170938617) and the European Commision (H2020-MSCA-IF 2018, 841729). NS was supported by an Institut Pasteur Roux Cantarini fellowship., We thank the UTechS CB of the Center for Translational Research, Institut Pasteur for supporting Nanostring analysis. DD thanks Immunoqure for provision of the mAbs under an MTA for the Simoa IFN-α assay. We are grateful to the study participants and the SATVI clinical and laboratory teams., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Frontiers in Immunology
Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.897193⟩

مصطلحات موضوعية: Tuberculosis, Immunology, Disease, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Interleukin 1 (IL-1), Medicine, Immunology and Allergy, Interleukin 1 Receptor antagonist (IL-1ra), 030304 developmental biology, Systems immunology, 0303 health sciences, Immunometabolism, biology, business.industry, biology.organism_classification, medicine.disease, 3. Good health, Granzyme, biology.protein, [SDV.IMM]Life Sciences [q-bio]/Immunology, Tumor necrosis factor alpha, business, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7d66d578f973127265656a16479c84Test
https://doi.org/10.3389/fimmu.2022.897193Test

المؤلفون: Taina Härkönen, Minna Kiviniemi, Mikael Knip, Antti Laine, Johanna Lempainen, Jorma Toppari, Jorma Ilonen, Riitta Veijola, Lucas Nygård

المساهمون: HUS Children and Adolescents, Children's Hospital, Research Group Knip

المصدر: Human Immunology. 82:912-916

مصطلحات موضوعية: Male, HLA-DR3, musculoskeletal diseases, SAMPLE, endocrine system diseases, Immunology, Single-nucleotide polymorphism, Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, MELLITUS, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, Polymorphism (computer science), DR-DQ HAPLOTYPES, Genotype, Humans, Immunology and Allergy, SNP, Genetic Predisposition to Disease, Expression quantitative trait locus, skin and connective tissue diseases, Finland, 030304 developmental biology, RISK, Genetics, 0303 health sciences, Haplotype, nutritional and metabolic diseases, ASSOCIATION, General Medicine, ALLELES, Introns, Single nucleotide polymorphism, Diabetes Mellitus, Type 1, Type 1 diabetes, 3121 General medicine, internal medicine and other clinical medicine, Expression quantitative trait loci, Female, HLA-DRB1 Chains, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd5ece1b48b95f9b3b9edde750b4dc3Test
https://doi.org/10.1016/j.humimm.2021.07.010Test

المؤلفون: Xin Zeng, Lu Sun, Yan-Hua Du, Cheng-cui Huang, Ming-Ming Ma, Hua-Qing Zheng, Yong-Yuan Guan, Ya-juan Zhang, Xiaofei Lv, Xiao-long Li, Guan-Lei Wang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3994-4007 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: MLCK, myosin light chain kinase, Myosin light-chain kinase, Vascular smooth muscle, RHOA, Smooth muscle cell migration, Integrin, RM1-950, MLC20, myosin light chain 20, 03 medical and health sciences, 0302 clinical medicine, MYPT1, myosin phosphatase target subunit 1, WNK1, with-no-lysine kinase 1, Vascular remodeling, ROCK2, General Pharmacology, Toxicology and Pharmaceutics, WNK1, BASMCs, basilar artery smooth muscle cells, 030304 developmental biology, TMEM16A, 0303 health sciences, biology, FAK, Chemistry, AngII, angiotensin II, Angiotensin II, Cell biology, F-actin, filamentous actin, SMTg, smooth muscle-specific TMEM16A transgenic mice, CaCC, Ca2+-activated chloride channel, FAK, focal adhesion kinase, MLCP, myosin light chain phosphates, 030220 oncology & carcinogenesis, Hypertension, VSMC migration, biology.protein, cardiovascular system, RhoA/ROCK, Original Article, Myosin-light-chain phosphatase, Therapeutics. Pharmacology, Signal transduction, VSMCs, vascular smooth muscle cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2252c02263eb5818f231c5b54829c2Test
http://www.sciencedirect.com/science/article/pii/S2211383521001416Test

المؤلفون: Augustine M.K. Choi, Mi-Ae Park, Mijin Yun, Chun K. Kim, Kiichi Nakahira, Jong Seok Moon, Maria Haslip, Ilias I. Siempos, Judie A. Howrylak, Patty J. Lee, Seonmin Lee, Stefan W. Ryter

المصدر: Journal of Clinical Investigation. 133

مصطلحات موضوعية: Inflammasomes, Interleukin-1beta, Caspase 1, Down-Regulation, Biology, Ion Channels, Proinflammatory cytokine, Mitochondrial Proteins, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Sepsis, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Uncoupling Protein 2, Lipid Synthesis Pathway, Fatty acid synthesis, 030304 developmental biology, Mice, Knockout, 0303 health sciences, integumentary system, Macrophages, Interleukin-18, Lipid metabolism, Inflammasome, General Medicine, Lipids, Cerulenin, Cell biology, Fatty Acid Synthase, Type I, Fatty acid synthase, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Enzyme Induction, biology.protein, Carrier Proteins, medicine.drug, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9632ffd7e04030d4fbaad1f96f28b3ddTest
https://doi.org/10.1172/jci169986Test

المؤلفون: Mingxiao Yin, Xiaojia Liu, Na Zhang, Genxiang Mao, Lu Liu, Hongbin Deng, Peng Yang, Wenjian Min, Kuang Ze'an, Jingwen Dong

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3134-3149 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: MDSCs, myeloid-derived suppressor cells, medicine.medical_treatment, CQ, chloroquine, mTORC1, Transcription factor EB, urologic and male genital diseases, TFEB, nuclear transcriptional factor EB, CETSA, cellular thermal shift assay, 0302 clinical medicine, Cancer immunotherapy, ICB, immune checkpoint blockade, General Pharmacology, Toxicology and Pharmaceutics, p70S6K, phosphorylation of p70 S6 kinase, 0303 health sciences, biology, Chemistry, qRT-PCR, quantitative real-time polymerase chain reaction, Lysosome, medicine.anatomical_structure, 030220 oncology & carcinogenesis, mTOR, Original Article, IHC, immunohistochemistry, PD-L1, SPR, surface plasmon resonance, mTOR, mammalian target of rapamycin, RM1-950, PD-L1, programmed cell death ligand- 1, 03 medical and health sciences, CHX, cycloheximide, NSCLC, non-small cell lung cancer, Tregs, regulatory T-lymphocytes, medicine, NAG, β-N-acetylglucosaminidase, IB, immunoblotting, PI3K/AKT/mTOR pathway, 030304 developmental biology, PD-1, programmed cell death-1, Baf, bafilomycin A1, Immune checkpoint, 4EBP1, eIF4E-binding protein 1, TILs, tumor-infiltrating lymphocytes, Cancer cell, biology.protein, Cancer research, TFEB, LLC, Lewis lung carcinoma, Therapeutics. Pharmacology, TBM-1, tubeimoside-1, Immune checkpoint blockade

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d344df92d314f733377ab3c9584020Test
http://www.sciencedirect.com/science/article/pii/S2211383521001118Test

المؤلفون: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)

مصطلحات موضوعية: Genome instability, PD-L1, programmed death ligand 1, BRCA, breast cancer susceptibility gene, ICI, immune checkpoint inhibitor, medicine.medical_treatment, MUTYH, MutY homolog, cGAS, cyclic GMP–AMP synthase, Review, DNA damage response, Malignant transformation, ORR, objective response rate, PCR, polymerase chain reaction, 0302 clinical medicine, SCNAs, somatic copy number alterations, FDA, United State Food and Drug Administration, Cancer immunotherapy, MGMT, O6-methylguanine methyltransferase, PD-1, RB1, retinoblastoma 1, General Pharmacology, Toxicology and Pharmaceutics, BER, base excision repair, RAD51C, RAD51 homolog C, 0303 health sciences, TME, tumor microenvironment, TP53, tumor protein P53, cGAS–STING, MSI, microsatellite instability, TRIF, Toll-interleukin 1 receptor domain-containing adaptor inducing INF-β, PFS, progression-free survival, STAT, signal transducer and activator of transcription, NEK1, NIMA-related kinase 1, Tumor microenvironment, PALB2, partner and localizer of BRCA2, RSR, replication stress response, 030220 oncology & carcinogenesis, Immunotherapy, PARP, poly-ADP ribose polymerase, JAK, Janus kinase, IHC, immunohistochemistry, Genomic instability, PD-L1, DSBs, double-strand breaks, DNA repair, DNA damage, CHK1, checkpoint kinase 1, IRF1, interferon regulatory factor 1, MLH1, MutL homolog 1, RM1-950, MMR, mismatch repair, STING, stimulator of interferon genes, Biology, MNT, MAX network transcriptional repressor, DDR, DNA damage response, MSH2/6, MutS protein homologue-2/6, OS, overall survival, RPA, replication protein A, 03 medical and health sciences, GSK3β, glycogen synthase kinase 3β, NER, nucleotide excision repair, NSCLC, non-small cell lung cancer, MyD88, myeloid differentiation factor 88, ssDNA, single-stranded DNA, medicine, DAMP, damage-associated molecular patterns, DR, direct repair, 030304 developmental biology, BAP1, BRCA1-associated protein 1, BRAF, v-RAF murine sarcoma viral oncogene homologue B, TLR4, Toll-like receptor 4, Cancer, NGS, next generation sequencing, ATM, ataxia-telangiectasia mutated, NIMA, never-in-mitosis A, medicine.disease, CHEK, cell-cycle checkpoint kinase, PD-1, programmed death 1, MAD1, mitotic arrest deficient-like 1, body regions, IFNγ, interferon gamma, TILs, tumor-infiltrating lymphocytes, TBK1, TANK-binding kinase 1, ATR, ataxia telangiectasia and Rad3 related, Cancer research, NHEJ, nonhomologous end-joining, Therapeutics. Pharmacology, HMGB1, high mobility group box-1, HRR, homologous recombination repair, XRCC4, X-ray repair cross complementing protein 4, TMB, tumor mutational burden

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe73202674a833d134ec811bcbf7332Test
https://doi.org/10.1016/j.apsb.2021.01.003Test