نتائج البحث

1

Elevated angiotensin II induces platelet apoptosis through promoting oxidative stress in an AT1R‐dependent manner during sepsis

المؤلفون: Dun-Feng Xu, Yu-Jian Liu, Chu-Fan Xu, Yan Wang, Yan-Fei Mao, Lai Jiang, Xiao-Yan Zhu

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: Male, 0301 basic medicine, thrombocytopenia, Apoptosis, Pharmacology, medicine.disease_cause, Mice, 0302 clinical medicine, Platelet, Cells, Cultured, platelet, Aged, 80 and over, chemistry.chemical_classification, Angiotensin II, Middle Aged, Prognosis, Losartan, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, Female, Signal Transduction, medicine.drug, Adult, Blood Platelets, reactive oxygen species (ROS), Receptor, Angiotensin, Type 1, Sepsis, 03 medical and health sciences, medicine, Animals, Humans, angiotensin II (Ang II), Aged, Cell Proliferation, Reactive oxygen species, Intrinsic apoptosis, angiotensin II receptor blocker (ARB), Original Articles, Cell Biology, medicine.disease, Oxidative Stress, 030104 developmental biology, Gene Expression Regulation, chemistry, Case-Control Studies, Reactive Oxygen Species, Angiotensin II Type 1 Receptor Blockers, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6123010f834858f85232068229ee63deTest
https://doi.org/10.1111/jcmm.16382Test

2

Insulin-like growth factor-1 receptor induces immunosuppression in lung cancer by upregulating B7–H4 expression through the MEK/ERK signaling pathway

المؤلفون: Bin Zhou, Moli Huang, Ningyue Zhang, Lei Zhang, Fengying Wu, Zhiming Zhao, Shaomu Chen, Yali Chen, Anqi Li

المصدر: Cancer Letters. 485:14-26

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Lung Neoplasms, MAP Kinase Signaling System, medicine.medical_treatment, CD8-Positive T-Lymphocytes, Receptor, IGF Type 1, Mice, 03 medical and health sciences, Insulin-like growth factor, 0302 clinical medicine, Cell Line, Tumor, Immune Tolerance, medicine, Animals, Humans, Cytotoxic T cell, Lung cancer, Aged, Insulin-like growth factor 1 receptor, Aged, 80 and over, Chemistry, Middle Aged, V-Set Domain-Containing T-Cell Activation Inhibitor 1, medicine.disease, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, body regions, 030104 developmental biology, Oncology, Tumor progression, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Female, Signal transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d9197cad7c5256237276c3d1dc6571Test
https://doi.org/10.1016/j.canlet.2020.04.013Test

3

NRP1 and MMP9 are dual targets of RNA‐binding protein QKI5 to alter VEGF‐R/ NRP1 signalling in trophoblasts in preeclampsia

المؤلفون: Xingyu Yang, Biwei He, Dan Chen, Weiwei Cheng

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, Adult, medicine.medical_treatment, MMP9, preeclampsia, 03 medical and health sciences, Mice, 0302 clinical medicine, Pre-Eclampsia, In vivo, Cell Movement, Pregnancy, Neuropilin 1, medicine, NRP1, QKI5, Animals, Humans, Secretion, Cell Proliferation, Cell growth, Chemistry, Growth factor, Trophoblast, RNA-Binding Proteins, Cell Biology, Original Articles, trophoblast, Hedgehog signaling pathway, Neuropilin-1, Cell biology, Trophoblasts, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Receptors, Vascular Endothelial Growth Factor, Matrix Metalloproteinase 9, 030220 oncology & carcinogenesis, Case-Control Studies, Molecular Medicine, Original Article, Female, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4918015cab186bc5d21a6f1f0b02e93Test
http://europepmc.org/articles/PMC8184681Test

4

SLAM/SAP Decreased Follicular Regulatory T Cells in Patients with Graves’ Disease

المؤلفون: Zhigang Hu, Jun Yang, Huaxi Xu, Shengjun Wang, Yingzhao Liu, Jie Tian, Xinyi Tang, Huiyong Peng, Lina Geng

المصدر: Journal of Immunology Research
Journal of Immunology Research, Vol 2021 (2021)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Article Subject, Graves' disease, Immunology, T-Lymphocytes, Regulatory, CD19, CXCR5, 03 medical and health sciences, 0302 clinical medicine, Signaling lymphocytic activation molecule, Signaling Lymphocytic Activation Molecule Family Member 1, Internal medicine, Follicular phase, medicine, Humans, Immunology and Allergy, Lymphocyte Count, Signaling Lymphocytic Activation Molecule Associated Protein, 030304 developmental biology, B-Lymphocytes, 0303 health sciences, biology, Chemistry, Autoantibody, FOXP3, General Medicine, RC581-607, Middle Aged, medicine.disease, Graves Disease, Healthy Volunteers, Endocrinology, Case-Control Studies, biology.protein, Female, Immunologic diseases. Allergy, Signal transduction, Research Article, Signal Transduction, 030215 immunology

وصف الملف: text/xhtml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2a9715506ca7ff9eec6bf36d941ed6Test
https://doi.org/10.1155/2021/5548463Test

5

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

المؤلفون: Snuggs J, Shannon N. Tessier, Makarand V. Risbud, Irving M. Shapiro, R A B Bunning, C. L. Le Maitre

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cell biology, Nucleus Pulposus, Molecular biology, Science, Primary Cell Culture, Aquaporin, Intervertebral Disc Degeneration, Article, Mice, 03 medical and health sciences, Rheumatic diseases, Chondrocytes, 0302 clinical medicine, Downregulation and upregulation, Enhancer binding, Gene expression, Animals, Humans, RNA, Small Interfering, Rats, Wistar, Mice, Knockout, Gene knockdown, Multidisciplinary, Aquaporin 1, Osmotic concentration, Chemistry, Osmolar Concentration, Middle Aged, Aquaporin 5, Rats, Mice, Inbred C57BL, Mechanisms of disease, 030104 developmental biology, Gene Expression Regulation, Tonicity, Medicine, Female, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee143d3c36cf2973f715cac5f156fecTest
https://doaj.org/article/4138b596e4be471abac6b99852763239Test

6

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

المصدر: Nat Immunol

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Galectin 1, Lipopolysaccharide, Mice, chemistry.chemical_compound, 0302 clinical medicine, Alarmins, Immunology and Allergy, Caspase, Aged, 80 and over, Mice, Knockout, biology, Intracellular Signaling Peptides and Proteins, Pyroptosis, Middle Aged, Up-Regulation, Cell biology, Necroptosis, Female, Inflammation Mediators, medicine.symptom, Signal transduction, Intracellular, Signal Transduction, Adult, animal structures, Immunology, Inflammation, PTPRC, Article, 03 medical and health sciences, Sepsis, otorhinolaryngologic diseases, medicine, Animals, Humans, Aged, Macrophages, Phosphate-Binding Proteins, Endotoxemia, Mice, Inbred C57BL, Disease Models, Animal, stomatognathic diseases, RAW 264.7 Cells, 030104 developmental biology, chemistry, Case-Control Studies, biology.protein, Leukocyte Common Antigens, HeLa Cells, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd368de112bdf46f79b07a7aa7e0a0dTest
https://doi.org/10.1038/s41590-020-00844-7Test

7

Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid

المؤلفون: Mariana Rodrigues Davanso, Cátia Lira do Amaral, Maria Lúcia Corrêa-Giannella, Dhêmerson Souza de Lima, Eicke Latz, Niels Olsen Saraiva Camara, Vinícius Nunes Cordeiro Leal, Tarcio Teodoro Braga, Amanda Rabello Crisma, Carl Christian Kolbe, José Alexandre Marzagão Barbuto, Thiago A. Patente, Alessandra Pontillo, Laureane Nunes Masi, Rui Curi, Mario A.R. Lauterbach

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Chemokine, Docosahexaenoic Acids, endocrine system diseases, DIABETES MELLITUS, medicine.medical_treatment, Anti-Inflammatory Agents, Nitric Oxide Synthase Type II, Nod, Peripheral blood mononuclear cell, Streptozocin, Diabetes Mellitus, Experimental, Proinflammatory cytokine, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Mice, Inbred NOD, Pregnancy, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Macrophage, Cells, Cultured, Inflammation, Mice, Knockout, biology, Chemistry, General Medicine, Macrophage Activation, Middle Aged, Mice, Inbred C57BL, Diabetes Mellitus, Type 1, 030104 developmental biology, Cytokine, Endocrinology, Docosahexaenoic acid, Macrophages, Peritoneal, biology.protein, Cytokines, Female, Inflammation Mediators, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2837be5004c09648659ea94fb4f2d8Test
https://doi.org/10.1042/cs20201348Test

8

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals

المؤلفون: Qiong Xia, Huimin Zhang, Jörg J. Goronzy, Timothy M. Gould, Jun Jin, Wenqiang Cao, Cornelia M. Weyand, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Chulwoo Kim, Xuanying Li

المصدر: Sci Immunol

مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Adoptive cell transfer, Endosome, T cell, Immunology, Vesicular Transport Proteins, Autophagy-Related Proteins, Mice, Transgenic, Endosomes, mTORC1, CD8-Positive T-Lymphocytes, Mechanistic Target of Rapamycin Complex 1, Transfection, Article, Large Neutral Amino Acid-Transporter 1, Mice, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Cells, Cultured, Late endosome, Aged, Aged, 80 and over, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Forkhead Box Protein O1, SARS-CoV-2, Chemistry, COVID-19, Germinal center, General Medicine, Adoptive Transfer, Healthy Volunteers, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Female, biological phenomena, cell phenomena, and immunity, Lysosomes, Memory T cell, CD8, Signal Transduction, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e04953a5d97e002d06400ddf6cb4899Test
https://doi.org/10.1126/sciimmunol.abg0791Test

9

Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway

المؤلفون: Shiqi Wang, Zhongyan Shan, Qiong Wu, Xiaoli Wang, Xiaoguang Shi, Lei Zhao, Weiping Teng

المصدر: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, T cell, immunometabolism, Tregs, Hashimoto Disease, HIF1a, Deoxyglucose, Thyroiditis, Diseases of the endocrine glands. Clinical endocrinology, Autoimmune thyroiditis, 03 medical and health sciences, Mice, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Animals, Humans, Glycolysis, Thyroiditis, Subacute, PI3K/AKT/mTOR pathway, Original Research, Aged, Glucose Transporter Type 1, Chemistry, TOR Serine-Threonine Kinases, Thyroid, Hashimoto’s thyroiditis, glycolysis, Middle Aged, Th1 Cells, medicine.disease, RC648-665, Hypoxia-Inducible Factor 1, alpha Subunit, Metformin, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, T cell differentiation, Th17 Cells, Female, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd9f08d28f4f66078993065e54d45caTest
http://europepmc.org/articles/PMC8211914Test

10

Extracellular vesicles‐encapsulated let‐7i shed from bone mesenchymal stem cells suppress lung cancer via KDM3A/DCLK1/FXYD3 axis

المؤلفون: Jiefeng Liu, Yiping Liu, Yuhua Feng, Yujing Gong, Xinyu Zeng, Miao He

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: Male, 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, Lung Neoplasms, doublecortin‐like kinase 1, Histones, Mice, Doublecortin-Like Kinases, 0302 clinical medicine, medicine.diagnostic_test, Chemistry, Kinase, Intracellular Signaling Peptides and Proteins, Middle Aged, FXYD domain‐containing ion transport regulator 3, Lysine demethylase 3A, Neoplasm Proteins, let‐7i, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Heterografts, Molecular Medicine, Female, Original Article, Signal Transduction, Adult, Protein Serine-Threonine Kinases, Models, Biological, Extracellular Vesicles, 03 medical and health sciences, Western blot, Cell Line, Tumor, microRNA, medicine, Animals, Humans, lysine demethylase 3A, Lung cancer, Aged, Reporter gene, Mesenchymal stem cell, Membrane Proteins, Mesenchymal Stem Cells, Original Articles, Cell Biology, medicine.disease, Disease Models, Animal, MicroRNAs, lung cancer, 030104 developmental biology, bone marrow mesenchymal stem cell, Cancer research, Bone marrow

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a2c0db58225736145c804c9ceca915Test
https://doi.org/10.1111/jcmm.15866Test

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