نتائج البحث

1

Pharmacokinetics of gallic acid and protocatechuic acid in humans after dosing with Relinqing (RLQ) and the potential for RLQ-perpetrated drug–drug interactions on organic anion transporter (OAT) 1/3

المؤلفون: Xi Du, Yanfen Li, Weidang Wu, Jinxia Sun, Yuhong Huang, Changxiao Liu, Yanguang Cao, Ziqiang Li, Ruihua Wang, Baohe Wang

المصدر: Pharmaceutical Biology, Vol 59, Iss 1, Pp 757-768 (2021)
Pharmaceutical Biology
article-version (VoR) Version of Record

مصطلحات موضوعية: Drug, Adult, Male, chinese patent medicine, Organic anion transporter 1, media_common.quotation_subject, organic anion transporter, Pharmaceutical Science, RM1-950, Pharmacology, Organic Anion Transporters, Sodium-Independent, 030226 pharmacology & pharmacy, 01 natural sciences, Protocatechuic acid, Madin Darby Canine Kidney Cells, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Dogs, Organic Anion Transport Protein 1, Pharmacokinetics, Gallic Acid, Drug Discovery, Hydroxybenzoates, Animals, Humans, Drug Interactions, Dosing, Gallic acid, media_common, biology, General Medicine, 0104 chemical sciences, pharmacokinetic markers (pk-markers), 010404 medicinal & biomolecular chemistry, HEK293 Cells, Complementary and alternative medicine, chemistry, biology.protein, Molecular Medicine, Female, Therapeutics. Pharmacology, Research Article, Drugs, Chinese Herbal, herb-drug interactions (hdi)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f37be11fbdeceddca01fbed0c65673Test
https://doaj.org/article/a45e55e8e1424759b5fc58a364410d78Test

2

Tumor-derived extracellular vesicles containing microRNA-1290 promote immune escape of cancer cells through the Grhl2/ZEB1/PD-L1 axis in gastric cancer

المؤلفون: Yang Liu, Heng Zhang, Yuan Liang, Jiang Du, Qingfu Zhang

المصدر: Translational Research. 231:102-112

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, T cell, medicine.disease_cause, B7-H1 Antigen, Cell Line, Extracellular Vesicles, Mice, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, In vivo, Cell Line, Tumor, Physiology (medical), PD-L1, microRNA, medicine, Animals, Humans, Aged, Aged, 80 and over, Mice, Inbred C3H, biology, Chemistry, Biochemistry (medical), Public Health, Environmental and Occupational Health, Zinc Finger E-box-Binding Homeobox 1, Cancer, Neoplasms, Experimental, General Medicine, Middle Aged, Oncomir, medicine.disease, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Cancer research, Female, Carcinogenesis, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72defe739f18d8ad764d3ccec1e438dTest
https://doi.org/10.1016/j.trsl.2020.12.003Test

3

TRIM21 drives intervertebral disc degeneration induced by oxidative stress via mediating HIF-1α degradation

المؤلفون: Changwei Li, Jiancheng Zheng, Leilei Chang, Xingkai Zhang, Lianfu Deng, Xiaogang Bao

المصدر: Biochemical and Biophysical Research Communications. 555:46-53

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Nucleus Pulposus, Adolescent, Biophysics, Intervertebral Disc Degeneration, Degeneration (medical), Oxidative phosphorylation, medicine.disease_cause, Biochemistry, Rats, Sprague-Dawley, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Downregulation and upregulation, medicine, Animals, Humans, Molecular Biology, Cells, Cultured, Aged, biology, Chemistry, Intervertebral disc, Hydrogen Peroxide, Cell Biology, Middle Aged, Hypoxia-Inducible Factor 1, alpha Subunit, Ubiquitin ligase, Cell biology, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Ribonucleoproteins, 030220 oncology & carcinogenesis, Disc degeneration, biology.protein, Female, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f9723c47a8babbaba448cb61e293abTest
https://doi.org/10.1016/j.bbrc.2021.03.088Test

4

MicroRNA-138-5p regulates the development of spinal cord injury by targeting SIRT1

المؤلفون: Rujie Qin, Jinchuan Chen

المصدر: Molecular Medicine Reports

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Cancer Research, Small interfering RNA, Biochemistry, sirtuin 1, PC12 Cells, Proinflammatory cytokine, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Genetics, PTEN, Animals, Humans, Viability assay, microRNA-138-5p, Molecular Biology, PI3K/AKT/mTOR pathway, Spinal Cord Injuries, biology, Chemistry, Akt/PKB signaling pathway, Sirtuin 1, apoptosis, Articles, Middle Aged, spinal cord injury, Rats, MicroRNAs, 030104 developmental biology, Oncology, Gene Expression Regulation, inflammation, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Molecular Medicine, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbf9c6494e655a4f46d1b7b031e95b3Test
http://europepmc.org/articles/PMC7248466Test

5

Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes

المؤلفون: Dagmar Meyer zu Heringdorf, Corina Ratiu, Amro Elgheznawy, Voahanginirina Randriamboavonjy, Anastasia Kyselova, Ingrid Fleming, Mauro Siragusa, Alexander W. Mann, Beate Fisslthaler, Fredy Delgado Lagos

المصدر: Blood. 137:1641-1651

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcf0b32aeb935a44038d5325894fca8Test
https://doi.org/10.1182/blood.2020009405Test

6

Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator

المؤلفون: Xiaomin Wang, Richard Hargreaves, Julie V. Selkirk, Sekhar Surapaneni, Jennifer Brooks, Yingzhuo Grace Yan, Peijin Zhang, Deepak Dalvie, Gondi Kumar, Maria Palmisano, Jonathan Q. Tran, Usha Yerramilli, April Bai

المصدر: Drug Metabolism and Disposition. 49:405-419

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9062b8ce5aa2ba048a27c73bf81ad566Test
https://doi.org/10.1124/dmd.120.000220Test

7

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

المصدر: Nat Immunol

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Galectin 1, Lipopolysaccharide, Mice, chemistry.chemical_compound, 0302 clinical medicine, Alarmins, Immunology and Allergy, Caspase, Aged, 80 and over, Mice, Knockout, biology, Intracellular Signaling Peptides and Proteins, Pyroptosis, Middle Aged, Up-Regulation, Cell biology, Necroptosis, Female, Inflammation Mediators, medicine.symptom, Signal transduction, Intracellular, Signal Transduction, Adult, animal structures, Immunology, Inflammation, PTPRC, Article, 03 medical and health sciences, Sepsis, otorhinolaryngologic diseases, medicine, Animals, Humans, Aged, Macrophages, Phosphate-Binding Proteins, Endotoxemia, Mice, Inbred C57BL, Disease Models, Animal, stomatognathic diseases, RAW 264.7 Cells, 030104 developmental biology, chemistry, Case-Control Studies, biology.protein, Leukocyte Common Antigens, HeLa Cells, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd368de112bdf46f79b07a7aa7e0a0dTest
https://doi.org/10.1038/s41590-020-00844-7Test

8

Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid

المؤلفون: Mariana Rodrigues Davanso, Cátia Lira do Amaral, Maria Lúcia Corrêa-Giannella, Dhêmerson Souza de Lima, Eicke Latz, Niels Olsen Saraiva Camara, Vinícius Nunes Cordeiro Leal, Tarcio Teodoro Braga, Amanda Rabello Crisma, Carl Christian Kolbe, José Alexandre Marzagão Barbuto, Thiago A. Patente, Alessandra Pontillo, Laureane Nunes Masi, Rui Curi, Mario A.R. Lauterbach

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Chemokine, Docosahexaenoic Acids, endocrine system diseases, DIABETES MELLITUS, medicine.medical_treatment, Anti-Inflammatory Agents, Nitric Oxide Synthase Type II, Nod, Peripheral blood mononuclear cell, Streptozocin, Diabetes Mellitus, Experimental, Proinflammatory cytokine, 03 medical and health sciences, Chemokine receptor, 0302 clinical medicine, Mice, Inbred NOD, Pregnancy, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Macrophage, Cells, Cultured, Inflammation, Mice, Knockout, biology, Chemistry, General Medicine, Macrophage Activation, Middle Aged, Mice, Inbred C57BL, Diabetes Mellitus, Type 1, 030104 developmental biology, Cytokine, Endocrinology, Docosahexaenoic acid, Macrophages, Peritoneal, biology.protein, Cytokines, Female, Inflammation Mediators, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2837be5004c09648659ea94fb4f2d8Test
https://doi.org/10.1042/cs20201348Test

9

Protein‐carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle

المؤلفون: Stewart Jeromson, Jessica R. Dent, Zhe Song, Leigh Breen, Simon W. Jones, Andrew Philp, Nathan Hodson, James Murray, D. Lee Hamilton, Mary F. O’Leary, Thomas Nicholson

المصدر: Experimental Physiology. 105:2178-2189

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Physiology, Muscle Fibers, Skeletal, Carbohydrates, P70-S6 Kinase 1, mTORC1, 030204 cardiovascular system & hematology, Cell Line, Eating, Mice, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, medicine, Animals, Humans, Kinase activity, Muscle, Skeletal, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, Cellular localization, Nutrition and Dietetics, biology, Myogenesis, Chemistry, TOR Serine-Threonine Kinases, fungi, Skeletal muscle, General Medicine, Middle Aged, Class III Phosphatidylinositol 3-Kinases, Endocrinology, medicine.anatomical_structure, biology.protein, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bf3f9c38af16ea81a3f00a8f595157Test
https://doi.org/10.1113/ep088805Test

10

Synergistic effect of ibrutinib and CD19 CAR‐T cells on Raji cells in vivo and in vitro

المؤلفون: Yanyu Jiang, Q Deng, Rui Zhang, Lei Sun, Juan Mu, Meijing Liu, Zheng Li, Xuelin Wang

المصدر: Cancer Science

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, programmed cell death‐ligand 1, T-Lymphocytes, Chronic lymphocytic leukemia, Cell, Immunotherapy, Adoptive, Mice, chemistry.chemical_compound, Basic and Clinical Immunology, Raji cell line, 0302 clinical medicine, Piperidines, hemic and lymphatic diseases, chimeric antigen receptor, medicine.diagnostic_test, biology, Chemistry, General Medicine, Middle Aged, Combined Modality Therapy, Raji cell, Treatment Outcome, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Ibrutinib, Original Article, Female, Lymphoma, Large B-Cell, Diffuse, Adult, STAT3 Transcription Factor, Antigens, CD19, Receptors, Antigen, T-Cell, Bruton tyrosine kinase inhibitor, CD19, Immunophenotyping, Flow cytometry, 03 medical and health sciences, In vivo, Cell Line, Tumor, Biomarkers, Tumor, medicine, tumor microenvironment, Animals, Humans, Protein Kinase Inhibitors, Aged, Neoplasm Staging, Tumor microenvironment, Adenine, Original Articles, medicine.disease, Xenograft Model Antitumor Assays, Disease Models, Animal, 030104 developmental biology, biology.protein, Cancer research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49d2425f68eed7413004c23fbb5d00bTest
https://doi.org/10.1111/cas.14638Test

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