نتائج البحث

1

Molecular and behavioural abnormalities in the FUS-tg mice mimic frontotemporal lobar degeneration

المؤلفون: Diana Babaevskaya, Andrey Proshin, Igor Pomytkin, Margarita Oplatchikova, Tatyana Strekalova, Johannes P.J.M. de Munter, D. A. Pavlov, Allan V. Kalueff, Klaus-Peter Lesch, Ekaterina Lysikova, Anna Gorlova, Erik Ch. Wolters, Aleksei Umriukhin

المساهمون: Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience

المصدر: Journal of Cellular and Molecular Medicine, 24(17), 10251-10257. Wiley-Blackwell
Journal of Cellular and Molecular Medicine
J. Cell. Mol. Med.

مصطلحات موضوعية: Male, Pathology, amyotrophic lateral sclerosis, PROTEIN EXPRESSION, EXPERIMENTAL NEUROINFLAMMATION, REAL TIME POLYMERASE CHAIN REACTION, MOUSE, ANIMAL EXPERIMENT, stem cell therapy, FUS[1‐359]‐tg mice, Mice, 0302 clinical medicine, SUCROSE PREFERENCE TEST, CELECOXIB, BRAIN, MUTATION, FUS[1-359]-tg mice, Neurons, RNA BINDING PROTEIN FUS, Behavior, Animal, celecoxib, LOCOMOTION, Neurodegeneration, TRANSGENIC MOUSE, Brain, DEPRESSION, Riluzole, Spinal Cord, 030220 oncology & carcinogenesis, RNA ISOLATION, CALCIUM BINDING PROTEIN, DRUG EFFECT, medicine.medical_specialty, Short Communication, Short Communications, FUS PROTEIN, MOUSE, IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1, BEHAVIOR, ANIMAL, INTERLEUKIN-1BETA, NEUROINFLAMMATION, 03 medical and health sciences, TAIL SUSPENSION TEST, NONHUMAN, Social Behavior, ELEVATED PLUS MAZE TEST, INTERLEUKIN 1BETA, FRONTOTEMPORAL LOBAR DEGENERATION, Glycogen Synthase Kinase 3 beta, animal model, ANIMALS, ANIMAL, medicine.disease, FUS[1-359]-TG MICE, Molecular medicine, 030104 developmental biology, Mutation, HIPPOCAMPUS, emotionality and cognition, CYCLOOXYGENASE 1, HOME-CAGE ACTIVITY TEST, ABNORMAL BEHAVIOR, SPINAL CORD, GELATINASE B, CYCLOOXYGENASE 2, 0301 basic medicine, MATRIX METALLOPROTEINASES, NERVE CELL, Interleukin-1beta, Anti-Inflammatory Agents, Hippocampus, PREFRONTAL CORTEX, ANIMAL MODEL, UNCLASSIFIED DRUG, neuroinflammation, MARBLE BURYING TEST, ANXIETY, COGNITIVE DEFECT, TISSUE INHIBITOR OF METALLOPROTEINASE 1, PLASTICITY, Amyotrophic lateral sclerosis, NEURONS, MOLECULAR MARKER, Frontotemporal lobar degeneration, STEM CELL, riluzole, Muscle atrophy, GENOTYPE, ANTIINFLAMMATORY ACTIVITY, frontotemporal lobar degeneration, BIOLOGICAL MARKER, GLYCOGEN SYNTHASE KINASE 3BETA, Molecular Medicine, AMYOTROPHIC LATERAL SCLEROSIS, RNA-BINDING PROTEIN FUS, medicine.symptom, ANTIINFLAMMATORY AGENT, medicine.drug, STEM CELL THERAPY, GLYCOGEN SYNTHASE KINASE 3 BETA, CAGE TEST, METABOLISM, ADULT, INFLAMMATION, WESTERN BLOTTING, ANIMAL TISSUE, GENE MUTATION, OPEN FIELD TEST, EMOTION, medicine, Animals, RESIDENT-INTRUDER TEST, ARTICLE, NERVE DEGENERATION, Neuroinflammation, Inflammation, MALE, TUMOR NECROSIS FACTOR, INTRACEREBROVENTRICULAR DRUG ADMINISTRATION, business.industry, SOCIAL BEHAVIOR, ANTI-INFLAMMATORY AGENTS, Cell Biology, FRONTOTEMPORAL DEMENTIA, ANIMAL BEHAVIOR, EMOTIONALITY AND COGNITION, CONTROLLED STUDY, MICE, GLYCOGEN SYNTHASE KINASE 3ALPHA, Cyclooxygenase 2, RILUZOLE, COGNITION, RNA-Binding Protein FUS, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06827f1ecd2f754817e6fe6568533e8Test
https://cris.maastrichtuniversity.nl/en/publications/0162d1c6-abc0-4610-83d0-566d46a45289Test

2

Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance

المصدر: Cancer research, vol 80, iss 7
Cancer Res

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Drug Resistance, Angiogenesis Inhibitors, 0302 clinical medicine, Stem Cell Research - Nonembryonic - Human, Phytogenic, Antineoplastic Combined Chemotherapy Protocols, Tumor Microenvironment, 2.1 Biological and endogenous factors, Medicine, Aetiology, Cancer, Tumor, Neovascularization, Pathologic, Brain Neoplasms, Brain, Middle Aged, Phenotype, Cell Hypoxia, Up-Regulation, Gene Expression Regulation, Neoplastic, Bevacizumab, Oncology, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Female, Development of treatments and therapeutic interventions, Stem cell, medicine.symptom, Biotechnology, medicine.drug, Adult, Programmed cell death, Epithelial-Mesenchymal Transition, Oncology and Carcinogenesis, Antineoplastic Agents, Article, Lignans, Cell Line, Young Adult, 03 medical and health sciences, Rare Diseases, Downregulation and upregulation, Cell Line, Tumor, Human Umbilical Vein Endothelial Cells, Animals, Humans, Neoplasm Invasiveness, Chitinase-3-Like Protein 1, Oncology & Carcinogenesis, Neovascularization, Aged, Pathologic, Neoplastic, business.industry, Microarray analysis techniques, Biphenyl Compounds, Mesenchymal stem cell, Zinc Finger E-box-Binding Homeobox 1, Hypoxia (medical), Stem Cell Research, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Brain Disorders, Brain Cancer, 030104 developmental biology, Gene Expression Regulation, Drug Resistance, Neoplasm, Cancer research, Neoplasm, sense organs, Glioblastoma, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31078c3c37cef95ce34f6641ccd4652aTest
https://doi.org/10.1158/0008-5472.can-19-1305Test

3

MiR‐125b Loss Activated HIF1α/pAKT Loop, Leading to Transarterial Chemoembolization Resistance in Hepatocellular Carcinoma

المؤلفون: Niya Liu, Lei Zhao, Stephanie Roessler, Fubo Ji, Xin Zheng, Zhao Ma, Junfang Ji, Xiyang Wei, Shuting Xue, Jianjuan Zhang, Ruizhe Ren, Jiong Shi, Xing Guo, Zhaogang Liu, Xin Wei Wang, Linda Wong

المصدر: Hepatology

مصطلحات موضوعية: Male, 0301 basic medicine, Cohort Studies, Gene Knockout Techniques, Mice, 0302 clinical medicine, Aged, 80 and over, education.field_of_study, CD24, Liver Neoplasms, Middle Aged, Hepatocellular carcinoma, Neoplastic Stem Cells, Female, 030211 gastroenterology & hepatology, Liver cancer, Signal Transduction, medicine.drug, Adult, Carcinoma, Hepatocellular, Adolescent, Population, Transfection, Article, Young Adult, 03 medical and health sciences, Cancer stem cell, microRNA, Biomarkers, Tumor, medicine, Animals, Humans, Chemoembolization, Therapeutic, education, Aged, Hepatology, business.industry, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, digestive system diseases, MicroRNAs, HEK293 Cells, 030104 developmental biology, HIF1A, A549 Cells, Drug Resistance, Neoplasm, Erythropoietin, Cancer research, Transcriptome, business, Proto-Oncogene Proteins c-akt

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce8941f479b6e08e1b61631b60f15ceTest
https://doi.org/10.1002/hep.31448Test

4

Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers

المؤلفون: Xin Wei Wang, Ole Larsen, Julia S. Johansen, Colm J O'Rourke, Dan Høgdall, Jesper B. Andersen, Morten Mau-Sørensen, Mogens Karsboel Boisen, Astrid Z. Johansen, Dorte Linnemann, Hien Dang, Douglas V. N. P. Oliveira, Valentina M. Factor, Lars Henrik Jensen, Christian Dehlendorff, Mie Grunnet

المصدر: Høgdall, D, O'Rourke, C J, Dehlendorff, C, Larsen, O F, Jensen, L H, Johansen, A Z, Dang, H, Factor, V M, Grunnet, M, Mau-Sørensen, M, Oliveira, D V N P, Linnemann, D, Boisen, M K, Wang, X W, Johansen, J S & Andersen, J B 2020, ' Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers ', Clinical Cancer Research, vol. 26, no. 21, pp. 5655-5667 . https://doi.org/10.1158/1078-0432.CCR-19-2700Test
Clin Cancer Res

مصطلحات موضوعية: Adult, Male, musculoskeletal diseases, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Locally advanced, Inflammation, Deoxycytidine, Article, Disease-Free Survival, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, medicine, Animals, Humans, Antigens, Tumor-Associated, Carbohydrate, Prognostic biomarker, Chitinase-3-Like Protein 1, Aged, Cell Proliferation, Aged, 80 and over, Interleukin-6, Proportional hazards model, business.industry, Palliative Care, Middle Aged, Prognosis, Receptors, Interleukin-6, Gemcitabine, Progression-Free Survival, Clinical trial, Biliary Tract Neoplasms, 030104 developmental biology, Biliary tract, 030220 oncology & carcinogenesis, Female, medicine.symptom, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1883a3389ee7e27bcc0a6669a1e847Test
https://doi.org/10.1158/1078-0432.ccr-19-2700Test

5

Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin

المؤلفون: Noo Ri Lee, Beom Jun Kim, Kyong Oh Shin, Eun Jung Kim, Gareth G. Lavery, Hyun Jee Hwang, Kyungho Park, Young Bin Lee, Solam Lee, Chung Hyeok Lee, Eung Ho Choi, Sung Jay Choe

المصدر: International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5750, p 5750 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, 11-beta-hydroxysteroid dehydrogenase type 1, 030207 dermatology & venereal diseases, chemistry.chemical_compound, Mice, 0302 clinical medicine, Corticosterone, 11β-hydroxysteroid dehydrogenase type 1, Biology (General), Spectroscopy, Barrier function, Mice, Knockout, biology, integumentary system, glucocorticoids, General Medicine, Middle Aged, Computer Science Applications, Chemistry, Knockout mouse, Cytokines, Female, Inflammation Mediators, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Adult, medicine.medical_specialty, endocrine system, QH301-705.5, Catalysis, Permeability, Article, Inorganic Chemistry, 03 medical and health sciences, Young Adult, Lipid biosynthesis, Internal medicine, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Aged, Transepidermal water loss, Organic Chemistry, Hairless, Skin Aging, 030104 developmental biology, Endocrinology, chemistry, Gene Expression Regulation, biology.protein, Cortisone, Epidermis, barrier function, Biomarkers, epidermal lipids

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8084c8f5c816d4e38a571e81ad199fTest
https://pubmed.ncbi.nlm.nih.gov/34072239Test

6

Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes

المؤلفون: Federico Vázquez, Rosa-Maria Ampudia, Silvia Rodriguez-Fernandez, Laia Gomez-Muñoz, David Perna-Barrull, Marta Vives-Pi, Ruth M. Risueño, Daniel Maspoch, Irma Pujol-Autonell, Mary Cano-Sarabia, Eva Aguilera, Adrian Villalba

المساهمون: Fundació La Marató de TV3, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España)

المصدر: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Combination therapy, medicine.medical_treatment, Immunology, lcsh:Medicine, Nod, Neogenesis, Article, Diabetes Mellitus, Experimental, 03 medical and health sciences, Mice, Young Adult, 0302 clinical medicine, Endocrinology, Mice, Inbred NOD, Insulin-Secreting Cells, medicine, Animals, Humans, Insulin, lcsh:Science, NOD mice, Type 1 diabetes, Multidisciplinary, biology, Liraglutide, business.industry, lcsh:R, Transdifferentiation, Immunotherapy, medicine.disease, biology.organism_classification, Combined Modality Therapy, 030104 developmental biology, Diabetes Mellitus, Type 1, Treatment Outcome, 030220 oncology & carcinogenesis, Liposomes, lcsh:Q, Female, business, medicine.drug