نتائج البحث - "Brian S. J. Blagg"

1

The disruption of protein−protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

المؤلفون: Brian S. J. Blagg, Michael A. Serwetnyk

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1446-1468 (2021)

مصطلحات موضوعية: MD, middle domain, Review, SUMO, small ubiquitin-like modifier, TPR2A, tetratricopeptide-containing repeat 2A, chemistry.chemical_compound, 0302 clinical medicine, Immunophilins, polycyclic compounds, General Pharmacology, Toxicology and Pharmaceutics, Natural products, 0303 health sciences, biology, Small molecules, HIF-1α, hypoxia-inducing factor-1α, HSQC, heteronuclear single quantum coherence, Geldanamycin, Hsp90, CTD, C-terminal domain, Radicicol, Cell biology, 030220 oncology & carcinogenesis, HOP, Hsp70‒Hsp90 organizing protein, SAHA, suberoylanilide hydroxamic acid, Protein folding, ATP, adenosine triphosphate, Cdc37, cell division cycle 37, RM1-950, Protein–protein interaction, 03 medical and health sciences, TROSY, transverse relaxation-optimized spectroscopy, Heat shock protein, SAR, structure–activity relationship, NTD, N-terminal domain, Heat shock, 030304 developmental biology, Disruptors, TRAP1, Hsp75tumor necrosis factor receptor associated protein 1, Hsp90, 90-kD heat shock protein, Her-2, human epidermal growth factor receptor-2, Aha1, activator of Hsp90 ATPase homologue 1, HIP, Hsp70-interaction protein, hERG, human ether-à-go-go-related gene, PPI, protein−protein interaction, ADP, adenosine diphosphate, chemistry, Grp94, 94-kD glucose-regulated protein, biology.protein, Protein−protein interactions, Therapeutics. Pharmacology, Peptidomimetics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d551031a93c74226093f0f0844e22506Test
https://doi.org/10.1016Test/j.apsb.2020.11.015

2

First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020

المساهمون: University of Leeds, University Medical Center Groningen [Groningen] (UMCG), The University of Notre Dame [Sydney], University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), Rhodes University, Grahamstown, University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Bioénergétique et Ingénierie des Protéines (BIP ), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Agency for science, technology and research [Singapore] (A*STAR), University of Groningen [Groningen], University of Idaho [Moscow, USA], University of California [San Diego] (UC San Diego), University of California (UC), National Institute of Diabetes and Digestive and Kidney Diseases [Bethesda], The University of Texas Medical School at Houston, Department of Radiation Oncology [Munich], Ludwig-Maximilians-Universität München (LMU), Department of Biochemistry, University of Sussex, University of Sussex, University of Iowa [Iowa City], Department of Mathematics (Weizmann Institute of Science), Weizmann Institute of Science [Rehovot, Israël], SUNY Upstate Medical University, State University of New York (SUNY), University of North Carolina [Charlotte] (UNC), University of North Carolina System (UNC), University of California

المصدر: Cell Stress & Chaperones
Cell Stress and Chaperones
Cell Stress and Chaperones, 2021, 26 (2), pp.289-295. ⟨10.1007/s12192-021-01192-7⟩
Cell Stress and Chaperones, Springer Verlag, 2021, 26 (2), pp.289-295. ⟨10.1007/s12192-021-01192-7⟩

مصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], Cancer biology, Library science, HSP90 Heat-Shock Proteins, Hsp90, Molecular Chaperones/genetics, Biochemistry, Hsp70, 03 medical and health sciences, 0302 clinical medicine, Political science, International congress, CSSI Congress, Chaperones, Heat-Shock Proteins/genetics, Humans, Proteostasis/genetics, HSP70 Heat-Shock Proteins, Heat-Shock Proteins, 030304 developmental biology, 0303 health sciences, HSP70 Heat-Shock Proteins/genetics, Heat shock proteins, Cell Biology, Stress responses, Meeting Review, ddc, Cell stress, 030220 oncology & carcinogenesis, HSP90 Heat-Shock Proteins/genetics, Proteostasis, Molecular Chaperones

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2157c71bd2f03481bb806d4b6d32f004Test
https://hdl.handle.net/11370/7037eec0-2788-424e-a500-f9cdb68673f3Test

3

The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies

المؤلفون: Bradley M Keegan, Subhabrata Chaudhury, Brian S. J. Blagg

المصدر: Med Res Rev

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee18a9a3acd607a45e88a2fa0df2675fTest
https://pubmed.ncbi.nlm.nih.gov/32844464Test

4

Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway

المؤلفون: David I. Duron, Natalie K. Barker, Paul R. Langlais, Sanket J. Mishra, Brian S. J. Blagg, John M. Streicher, Carrie Stine, Wei Lei

المصدر: Sci Signal

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefa82d1ba022c18ed2409300f194004Test
https://doi.org/10.1126/scisignal.aaz1854Test

5

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

المصدر: Cell reports
Cell Reports, Vol 12, Iss 6, Pp 1006-1018 (2015)
Dunn, D M, Woodford, M R, Truman, A W, Jensen, S M, Schulman, J, Caza, T, Remillard, T C, Loiselle, D, Wolfgeher, D, Blagg, B S J, Franco, L, Haystead, T A, Daturpalli, S, Mayer, M P, Trepel, J B, Morgan, R M L, Prodromou, C, Kron, S J, Panaretou, B, Stetler-Stevenson, W G, Landas, S K, Neckers, L, Bratslavsky, G, Bourboulia, D & Mollapour, M 2015, ' c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells ', Cell Reports, vol. 12, no. 6, pp. 1006-1018 . https://doi.org/10.1016Test/j.celrep.2015.07.004