Glycemic control metrics using flash glucose monitoring and hospital complications in patients with COVID-19
| العنوان: | Glycemic control metrics using flash glucose monitoring and hospital complications in patients with COVID-19 |
|---|---|
| المؤلفون: | Ruby Jojoa, Alfonso Kerguelen, Carlos Augusto Yepes, Pablo Jaramillo, Pablo Aschner, Guillermo E. Umpierrez, Ana María Gómez, Oscar Muñoz, Diana Henao, Darío Parra |
| المصدر: | Diabetes & Metabolic Syndrome Diabetes & Metabolic Syndrome: Clinical Research & Reviews |
| بيانات النشر: | Published by Elsevier Ltd on behalf of Diabetes India., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, BMI, body mass index, Pilot Projects, Type 2 diabetes, 030204 cardiovascular system & hematology, Cohort Studies, Flash glucose monitoring, TAR, time above the range, 0302 clinical medicine, Insulin, Prospective Studies, Prospective cohort study, GMI, glucose management indicator, Respiratory Distress Syndrome, LDH, lactate dehydrogenase, General Medicine, Acute Kidney Injury, Middle Aged, RCP, reactive c protein, ICU, intensive care unit, WP, waist perimeter, Intensive Care Units, Point-of-Care Testing, Cohort, Female, CV%, coefficient of variation, Inpatient, Cohort study, TIR, time in range, medicine.medical_specialty, HBP, high blood pressure, TDDI, total daily dose of insulin, 030209 endocrinology & metabolism, A1c, glycosylated hemoglobin, Glycemic Control, Colombia, AKI, acute kidney injury, Article, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Basal bolus, medicine, Internal Medicine, Humans, Hypoglycemic Agents, CGM, continuous glucose monitoring, ARDS, acute respiratory distress syndrome, IQR, interquartile range, Aged, Monitoring, Physiologic, Glycemic, Glycated Hemoglobin, SARS-CoV-2, business.industry, COVID-19, medicine.disease, AMI, acute myocardial infarction, Regimen, RT-PCR, real time polymerase chain reaction, Diabetes Mellitus, Type 2, Hyperglycemia, TBR, time below the range, business |
| الوصف: | Background and aims Few studies have reported on the use of continuous glucose monitoring (CGM) during the Covid-19 pandemic. We aimed to examine glycemic control metrics using flash glucose monitoring during insulin treatment and the clinical outcome in hospitalized patients with COVID-19. Methods Prospective, single-center cohort of adult patients diagnosed with type 2 diabetes or hyperglycemia and COVID-19 infection treated with basal bolus insulin regimen. Glycemic control was assessed with the use of intermittent Freestyle Libre flash glucose monitoring during the hospital stay. Outcome of interest were time in range [TIR], time above [TAR] and below [TBR] range, glycemic variability [coefficient of variation [% CV]), and differences in a composite of complications including ICU admission, acute respiratory distress syndrome (ARDS) and acute kidney injury. Results A total of 60 patients were included (44 known diabetes and 16 new onset hyperglycemia). In total 190,080 data points of CGM were available, of which 72.5% of values were within the target area [TIR (70–180 mg/dL)], 22% TAR (>180 mg/dL), and 3% were TBR (180 mg/dl had higher rates of a composite of complications (22.5% vs 16%, p = 0.04). Conclusions Basal bolus insulin regimen was safe and effective in achieving inpatient glycemic control in most patients with COVID-19. The association between TAR and complications indicates the need for improved inpatient glycemic control in hospitalized patients with COVID-19. |
| اللغة: | English |
| تدمد: | 1878-0334 1871-4021 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06ce0c7098689ee8f1daeabc03820dcTest http://europepmc.org/articles/PMC7872843Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d06ce0c7098689ee8f1daeabc03820dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18780334 18714021 |
|---|