Resectable pancreatic head adenocarcinoma: Is R0 resection an illusion? Genetic evaluation of venous resection margin affirmed unrecognized disease
| العنوان: | Resectable pancreatic head adenocarcinoma: Is R0 resection an illusion? Genetic evaluation of venous resection margin affirmed unrecognized disease |
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| المؤلفون: | Turrini, O., Gilabert, M., Ewald, J., Moutardier, V., Delpero, J.-R., Iovanna, J.-L., Turrini, M |
| المساهمون: | Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU) |
| المصدر: | Journal of Visceral Surgery Journal of Visceral Surgery, 2017, 154 (5), pp.329-333. ⟨10.1016/j.jviscsurg.2017.05.009⟩ Journal of Visceral Surgery, Elsevier, 2017, 154 (5), pp.329-333. ⟨10.1016/j.jviscsurg.2017.05.009⟩ |
| بيانات النشر: | HAL CCSD, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Disease, Gene mutation, medicine.disease_cause, Gastroenterology, Cohort Studies, 0302 clinical medicine, Margin (machine learning), Portal Vein, Margins of Excision, General Medicine, Middle Aged, Prognosis, Pancreaticoduodenectomy, 3. Good health, Treatment Outcome, 030220 oncology & carcinogenesis, Adenocarcinoma, K-ras gene mutation, Female, 030211 gastroenterology & hepatology, KRAS, Adult, medicine.medical_specialty, [SDV.CAN]Life Sciences [q-bio]/Cancer, Risk Assessment, Disease-Free Survival, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Mesenteric Veins, Internal medicine, Pancreatic cancer, medicine, Humans, Aged, Retrospective Studies, business.industry, medicine.disease, Survival Analysis, Confidence interval, Pancreatic Neoplasms, Margins, Gene Expression Regulation, Mutation, Neoplasm Grading, business |
| الوصف: | International audience; KEYWORDS Pancreatic cancer; Margins; K-ras gene mutation Summary Purpose: To assess the K-ras gene mutation in the histologically negative venous margin of a pancreaticoduodenectomy (PD) specimen and its impact on survival. Method: From 2007 to 2010, 22 patients underwent R0 PD for resecable pancreatic adenocar-cinoma. All specimens were stained and the portal vein (PV) bed was identified by blue ink; a 2 mm 3 sample (including the blue ink) was cut from a microscopic free-tumor block. DNA was extracted and assessed by quantitative real time polymerase chain reaction to detect the K-ras gene mutation. Twelve specimens (55%) (kras+ group) were identified with a K-ras mutation in the venous margin resection, and 10 specimens (kras− group) did not have K-ras mutation detected in the venous margin resection. Results: The two groups were comparable. Overall 3 years survival of patients of kras+ group versus patients of kras− group was 0 and 17% (P = 0.03), respectively. Median survival time of patients of kras+ group versus patients of kras− group was 16 months vs 25 months (P = 0.04; 95% confidence interval [1,11—1,88]), respectively. Conclusion: Genetic evaluation of venous resection margin affirmed unrecognized disease with strong impact on survival in more than 50% of patients with histologically R0 resection. |
| اللغة: | English |
| تدمد: | 1878-7886 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7500c83a393c1e6a7f033bdf756fb841Test https://hal.science/hal-01789418Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7500c83a393c1e6a7f033bdf756fb841 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18787886 |
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