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1Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity
المؤلفون: Cláudia F. Campos, Daniela Antunes, Nuno S. Osório, Frank L. van de Veerdonk, Agostinho Carvalho, Samuel M. Gonçalves, Paulo Pereira, Ricardo Silvestre, Toine Mercier, Jean-Paul Latgé, Luís Leite, Miguel Fernández-García, Rob ter Horst, Leo A. B. Joosten, Egídio Torrado, Mihai G. Netea, Axel A. Brakhage, António Campos, Inês Mesquita, António Marques, Catarina Barbosa-Matos, Gordon D. Brown, Vishukumar Aimanianda, Joana Gaifem, Coral Barbas, Katrien Lagrou, Fernando Rodrigues, Johan Maertens, Georgios Chamilos, João F. Lacerda, Cláudio Duarte-Oliveira, Sandra Costa, Cristina Cunha, Cláudia S. Rodrigues
المساهمون: Life and Health Sciences Research Institute [Braga] (ICVS), University of Minho [Braga], Aspergillus, Institut Pasteur [Paris], Radboud University Medical Centre [Nijmegen, The Netherlands], University of Aberdeen, This work was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), the Fundação para a Ciência e Tecnologia (FCT) (SFRH/BD/136814/2018 to S.M.G., SFRH/BD/141127/2018 to C.D.O., PD/BD/137680/2018 to D.A., IF/00474/2014 to N.S.O., IF/01390/2014 to E.T., IF/00959/2014 to S.C., IF/00021/2014 to R.S., PTDC/SAU-SER/29635/2017 and CEECIND/04601/2017 to C.C., and CEECIND/03628/2017 to A.C.), the Institut Mérieux (Mérieux Research Grant 2017 to C.C.), and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Research Grant 2017 to A.C.). M.G.N. was supported by a Spinoza grant of the Netherlands Organization for Scientific Research. A.A.B. was supported by the Deutsche Forschungsgemeinschaft Collaborative Research Center/Transregio TR124 FungiNet (project A1). G.D.B. was funded by the Wellcome Trust (102705), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1)., Institut Pasteur [Paris] (IP), Radboud University Medical Center [Nijmegen], Repositório da Universidade de Lisboa
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-16120-z⟩
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11, 1
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-16120-z⟩
Nature Communications, 11مصطلحات موضوعية: 0301 basic medicine, Science, Phagocytosis, 030106 microbiology, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Immune system, Phagosomes, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Macrophage, Animals, Humans, Calcium Signaling, lcsh:Science, PI3K/AKT/mTOR pathway, ComputingMilieux_MISCELLANEOUS, Phagosome, Calcium signaling, Melanins, Multidisciplinary, Innate immune system, Chemistry, Aspergillus fumigatus, Macrophages, TOR Serine-Threonine Kinases, Immunity, General Chemistry, Dendritic cell, Hypoxia-Inducible Factor 1, alpha Subunit, 3. Good health, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Glucose, Lactates, lcsh:Q, Transcriptome, Glycolysis
وصف الملف: Electronic; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39af42e4090ba67c6e6ba1df82b0020Test
https://lirias.kuleuven.be/handle/123456789/655266Test -
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المؤلفون: Frank L. van de Veerdonk, Elias Drakos, Triantafyllos Chavakis, Isabel Valsecchi, Dimitrios P. Kontoyiannis, Anne Beauvais, Axel A. Brakhage, Irene Kyrmizi, Tonia Akoumianaki, Marie Christine Prevost, Jean-Paul Latgé, Mark S. Gresnigt, Laetitia Muszkieta, Dimitrios T. Boumpas, Georgios Chamilos, Mihai G. Netea, Jamel El-Benna, George Samonis
المصدر: Cell Host & Microbe, 19, 1, pp. 79-90
Cell Host & Microbe, 19, 79-90مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Phagocytosis, 030106 microbiology, ATG5, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Virulence, Microbiology, Autophagy-Related Protein 5, Aspergillus fumigatus, Cell wall, Melanin, Mice, 03 medical and health sciences, Cell Wall, Phagosomes, Immunology and Microbiology(all), Virology, Animals, Aspergillosis, Humans, Molecular Biology, Phagosome, Melanins, Aspergillus, biology, biology.organism_classification, Parasitology, Microtubule-Associated Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c54f26f9cff99b2d64b7559fc73274fTest
https://doi.org/10.1016/j.chom.2015.12.002Test