المؤلفون: Vincent Jaquet, Moises Di Sante, Ana I. Casas, Fabio Di Lisa, Alexandra Petraina, Nina Kaludercic, François Dufrasne, Antonio Cuadrado, Jalal Soubhye, Soni Deshwal, Cristian Nogales, Ana I. Rojo, Harald H.H.W. Schmidt, Hermann Mucke, Fiona Augsburger, Pietro Ghezzi

المساهمون: European Commission, European Research Council, Maastricht University

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Pharmacological reviews, 72 (4
Pharmacological Reviews

مصطلحات موضوعية: 0301 basic medicine, XANTHINE-OXIDASE, TRANSCRIPTION FACTOR NRF2, Disease, Biology, Antioxidants, AMYOTROPHIC-LATERAL-SCLEROSIS, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, SERUM URIC-ACID, SOLUBLE GUANYLATE-CYCLASE, Animals, Humans, Pharmacological modulation, Enzyme Inhibitors, NITRIC-OXIDE SYNTHASE, Chimie pharmaceutique, VITAMIN-E, Randomized Controlled Trials as Topic, Pharmacology, chemistry.chemical_classification, Reactive oxygen species, Clinical pharmacology, Mechanism (biology), Drug discovery, NADPH-OXIDASE, MONOAMINE-OXIDASE, 3. Good health, Chimie organique, Oxidative Stress, 030104 developmental biology, Cell metabolism, Drug development, chemistry, CARDIOVASCULAR-DISEASE, Molecular Medicine, Reactive Oxygen Species, Neuroscience, Oxidation-Reduction, 030217 neurology & neurosurgery

وصف الملف: 1 full-text file(s): application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b7e0141223de4d4cfb563f53a3d504Test
https://doi.org/10.1124/pr.120.019422Test

المؤلفون: Anna-Kaisa Ruotsalainen, Mikko I. Kettunen, Heping Xu, Maija Mutikainen, Goran Petrovski, Ali Koskela, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Heikki Tanila, Kai Kaarniranta, Juha M.T. Hyttinen, Szabolcs Felszeghy, Janusz Blasiak, Kati Kinnunen, Anna-Liisa Levonen, Pasi Tavi, Ari Koskelainen, Jussi J. Paterno, Debasish Sinha, Arto Urtti, Arto Koistinen, Jerzy Mackiewicz, Johanna Viiri, Heli Skottman, Elisa Toropainen, Marialaura Amadio, Ram Kannan, Niko Kivinen, Geir Bjørkøy, Deborah A. Ferrington, Henri Leinonen, Mei Chen, Kimmo Jokivarsi, Anu Kauppinen, Antero Salminen

المساهمون: Division of Pharmaceutical Biosciences, Drug Research Program, Drug Delivery Unit, University of Eastern Finland, Queen's University Belfast, University of Pavia, Medical University of Silesia in Katowice, University of Life Sciences in Lublin, Medical University of Lublin, Johns Hopkins University, University of Oslo, University of Łódź, Norwegian University of Science and Technology, Department of Neuroscience and Biomedical Engineering, Tampere University, University of Southern California, University of Minnesota Twin Cities, Aalto-yliopisto, Aalto University

المصدر: Felszeghy, S, Viiri, J, Paterno, J J, Hyttinen, J M T, Koskela, A, Chen, M, Leinonen, H, Tanila, H, Kivinen, N, Koistinen, A, Toropainen, E, Amadio, M, Smedowski, A, Reinisalo, M, Winiarczyk, M, Mackiewicz, J, Mutikainen, M, Ruotsalainen, A K, Kettunen, M, Jokivarsi, K, Sinha, D, Kinnunen, K, Petrovski, G, Blasiak, J, Bjørkøy, G, Koskelainen, A, Skottman, H, Urtti, A, Salminen, A, Kannan, R, Ferrington, D A, Xu, H, Levonen, A L, Tavi, P, Kauppinen, A & Kaarniranta, K 2019, ' Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration ', Redox Biology, vol. 20, pp. 1-12 . https://doi.org/10.1016/j.redox.2018.09.011Test
Felszeghy, Viiri, Paterno, Hyttinen, Koskela,, Chen, M, Leinonen, Tanila, Kivinen, Koistinen, Totopainen, Amadio, Smedowski, Reinisalo, Winiarczyk, Mackiewicz, Mutikainen,, Xu, H & Kaarniranta 2019, ' Loss of NRF-2 and PGC-1a genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration ' Redox Biology, vol. 20, pp. 1-12 . https://doi.org/10.1016/j.redox.2018.09.011Test
Redox Biology
Redox Biology, Vol 20, Iss, Pp 1-12 (2019)

مصطلحات موضوعية: 0301 basic medicine, Aging, Clinical Biochemistry, Cellular detoxification, TRANSCRIPTION FACTOR NRF2, Retinal Pigment Epithelium, Biochemistry, Macular Degeneration, Mice, 0302 clinical medicine, ANTIOXIDANT RESPONSE, lcsh:QH301-705.5, Endoplasmic Reticulum Chaperone BiP, ta116, Mice, Knockout, lcsh:R5-920, education.field_of_study, Chemistry, Endoplasmic Reticulum Stress, Immunohistochemistry, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mitochondria, Molecular Imaging, 3. Good health, Cell biology, Phenotype, medicine.anatomical_structure, RPE, Protein aggregation, lcsh:Medicine (General), NF-E2-Related Factor 2, Protein degradation, Protein Aggregation, Pathological, 03 medical and health sciences, Sequestosome 1, INFLAMMATION, Electroretinography, Autophagy, medicine, Animals, Genetic Predisposition to Disease, Photoreceptor Cells, education, Genetic Association Studies, DYSREGULATION, Retinal pigment epithelium, Proteasome, Endoplasmic reticulum, Organic Chemistry, ATF4, DEGRADATION, eye diseases, Protein ubiquitination, Disease Models, Animal, 030104 developmental biology, lcsh:Biology (General), Oxidative stress, CELLS, Mutation, Degeneration, 1182 Biochemistry, cell and molecular biology, sense organs, Lysosomes, Reactive Oxygen Species, Biomarkers, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1677e813524eb053eea0a201382fedabTest
https://doi.org/10.1016/j.redox.2018.09.011Test

المؤلفون: Shujiro Okuda, Takashi Ueno, Manabu Abe, Nobuaki Miura, Tsunehiro Mizushima, Naoki Tamura, Masaaki Komatsu, Jin-A Lee, Saiko Kazuno, Yoshinobu Ichimura, Yu-shin Sou, Satoshi Waguri, Eeva-Liisa Eskelinen, Tomoyuki Ohe, Kenji Sakimura, Yoshiki Miura, Sigurdur Runar Gudmundsson, Nobuo N. Noda, Hozumi Motohashi, Daisuke Noshiro, Shun Kageyama

المساهمون: Autophagy, Molecular and Integrative Biosciences Research Programme, Biosciences, Biochemistry and Biotechnology

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Autophagosome, P62, General Physics and Astronomy, TRANSCRIPTION FACTOR NRF2, Plasma protein binding, 0302 clinical medicine, Ubiquitin, Sequestosome-1 Protein, PHOSPHORYLATION, ELECTRON-MICROSCOPY, Kelch-Like ECH-Associated Protein 1, Multidisciplinary, biology, Chemistry, 3. Good health, Cell biology, Liver, Phosphorylation, Microtubule-Associated Proteins, Protein Binding, STRUCTURAL BASIS, NF-E2-Related Factor 2, Science, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Macroautophagy, Autophagy, Animals, Humans, SELECTIVE AUTOPHAGY, Transcription factor, Unilamellar Liposomes, Autophagosomes, RECOGNITION, General Chemistry, DEGRADATION, KEAP1, GENE, Mice, Inbred C57BL, Oxidative Stress, MICE, 030104 developmental biology, Hepatocytes, biology.protein, 1182 Biochemistry, cell and molecular biology, Apoptosis Regulatory Proteins, Lysosomes, Gels, 030217 neurology & neurosurgery, Biogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfb4be4fea4d888a2f39fe826705fd3Test
http://hdl.handle.net/10138/333044Test

المؤلفون: Marcin Gamdzyk, John H. Zhang, Prativa Sherchan, Pinar Eser Ocak, Jiping Tang, Umut Ocak

المساهمون: Bursa Uludağ Üniversitesi/Tıp Fakültesi., Ocak, Pınar Eser, AAI-2073-2021

المصدر: Exp Neurol

مصطلحات موضوعية: 0301 basic medicine, Male, Complications, Unclassified drug, Caveolin 1, Animals, Endothelial Nitric Oxide Synthase, Expression, Injury, Pharmacology, Animal tissue, Hmox1 protein, rat, Rats, Sprague-Dawley, 0302 clinical medicine, Nfe2l2 protein, rat, Caveolae, Claudin-5, Brain injury, Inhibition, Priority journal, Kelch-Like ECH-Associated Protein 1, Heme oxygenase 1, Sprague Dawley rat, Tight junction, Behavior, Animal, Brain edema, Frontal Lobe, Heme oxygenase, Damage, Protein Mfsd2a, medicine.anatomical_structure, Treatment Outcome, Neurology, Blood brain barrier, Blood-Brain Barrier, Rat model, cardiovascular system, Signal transduction, Protects, Animal behavior, Cav-1, Surgical brain injury, KEAP1 protein, rat, Signal Transduction, Adult, NF-E2-Related Factor 2, Peptides and proteins, Neurosciences & neurology, Blood–brain barrier, Mfsd2a, Pathophysiology, Permeability, Article, Cerebral edema, Transcription factor Nrf2, 03 medical and health sciences, Gene therapy, Developmental Neuroscience, Downregulation and upregulation, Body Water, Occludin, Genetics, medicine, Animal model, Animal experiment, Adverse effect, Animal, business.industry, Kelch like ECH associated protein 1, Neurosciences, Genetic Therapy, Nonhuman, medicine.disease, Rats, Metabolism, 030104 developmental biology, Brain Injuries, Heme Oxygenase (Decyclizing), Protein expression, Rat, business, Controlled study, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82b873caa3d038126c415db7a2376dfTest
https://europepmc.org/articles/PMC7038791Test/

المؤلفون: Diego Lastra, Albena T. Dinkova-Kostova, Raquel Fernández-Ginés, Ana I. Rojo, Angel J. Garcia Yagüe, Marta Pajares, Antonio Cuadrado, Gina Manda, Cristina Benito, Maribel Escoll, José Jiménez-Villegas

المساهمون: Biotechnology and Biological Sciences Research Council (UK), Tenovus Scotland, Cancer Research UK, Comunidad de Madrid, Fundación Tatiana Pérez de Guzmán el Bueno, European Commission, UAM. Departamento de Bioquímica, UAM. Departamento de Medicina

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Trends in Pharmacological Sciences
Biblos-e Archivo. Repositorio Institucional de la UAM
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid

مصطلحات موضوعية: anti-inflammatory ARDS, 0301 basic medicine, ARDS, replication, NF-E2-Related Factor 2, Pneumonia, Viral, NF-KAPPA-B, Anti-Inflammatory Agents, Inflammation, Toxicology, Article, Proinflammatory cytokine, Alveolar cells, Transcription factor NRF2, 03 medical and health sciences, 0302 clinical medicine, medicine, Homeostasis, Humans, oxidative stress, Acute respiratory distress syndrome (ARDS), Bardoxolone methyl, Pandemics, Pharmacology, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Biología y Biomedicina / Biología, KEAP1, Cytoprotection, inhibition, 030104 developmental biology, medicine.anatomical_structure, Cancer research, medicine.symptom, Anti-inflammatory, Cytokine storm, business, Coronavirus Infections, Oxidation-Reduction, Sulforaphane, 030217 neurology & neurosurgery, Granulocytes

وصف الملف: application/pdf; 13 págs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e556e8fcbb6720f22271d73c492f7205Test
http://hdl.handle.net/10261/216654Test

المؤلفون: Miltiadis K. Tsilimbaris, Elfride De Baere, Thomas Langmann, Styliani V. Blazaki, Cécile Brachet, Giulia Ascari, Konstantinos Nikopoulos, Sarah Vergult, Françoise Meire, Thalia Van Laethem, Christian P. Hamel, Mingchu Xu, Katharina Dannhausen, Frank Peelman, Marieke De Bruyne, Bart P. Leroy, Miriam Bauwens, Marcus Karlstetter, Carlo Rivolta, Ruifang Sui, Isabelle Meunier, Rui Chen, Frauke Coppieters, Pietro Farinelli, Chrysanthi Tsika

المساهمون: Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

المصدر: American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2016, 99 (2), pp.470-480. ⟨10.1016/j.ajhg.2016.06.017⟩
American journal of human genetics, vol. 99, no. 2, pp. 470-480
American journal of human genetics, 99 (2
AMERICAN JOURNAL OF HUMAN GENETICS

مصطلحات موضوعية: 0301 basic medicine, Male, Génétique clinique, Turkey, TRANSCRIPTION FACTOR NRF2, PROTEIN, 030105 genetics & heredity, medicine.disease_cause, Consanguinity, Medicine and Health Sciences, CONJUGATING ENZYME, Missense mutation, Guanine Nucleotide Exchange Factors, Exome, Genetics(clinical), Lymphocytes, Age of Onset, Child, Genetics (clinical), Genetics, Mutation, CHROMOSOME 13Q14, Homozygote, EPITHELIAL-CELLS, DOMINANT RETINITIS-PIGMENTOSA, Syndrome, Disease gene identification, Cullin Proteins, Founder Effect, 3. Good health, Pedigree, Phenotype, Female, PROTEASOME SYSTEM, Biologie, Adult, Adolescent, NF-E2-Related Factor 2, Mutation, Missense, Genes, Recessive, Biology, Retina, 03 medical and health sciences, Report, Retinitis pigmentosa, Retinal Dystrophies, medicine, Humans, RNA, Messenger, Allele, Alleles, CHRONIC LYMPHOCYTIC-LEUKEMIA, RESPONSE ELEMENT, Haplotype, Ubiquitination, Biology and Life Sciences, medicine.disease, Molecular biology, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Haplotypes, Cullin Proteins/metabolism, Exome/genetics, Guanine Nucleotide Exchange Factors/genetics, Haplotypes/genetics, Lymphocytes/metabolism, Mutation, Missense/genetics, NF-E2-Related Factor 2/metabolism, RNA, Messenger/genetics, Retina/metabolism, Retinal Dystrophies/genetics, Ubiquitination/genetics, EXPRESSION ANALYSIS, Founder effect

وصف الملف: application/pdf; 1 full-text file(s): application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901a01da159db26ef9653517b759829dTest

المؤلفون: Přemysl Mladěnka, Rita Afonso, Luciano Saso, Kateřina Macáková

مصطلحات موضوعية: 0301 basic medicine, Antioxidant, DPPH, medicine.medical_treatment, aromatic compound, antioxidant activity, Pro-oxidant, Review, indole alkaloid, reactive oxygen metabolite, medicine.disease_cause, cholinergic receptor, Biochemistry, Antioxidants, Anti-oxidant, chemistry.chemical_compound, 0302 clinical medicine, oxidative stress, enzyme inhibition, chemistry.chemical_classification, alkaloid, hydroxyl group, isoquinoline alkaloid, protoalkaloid, pseudoalkaloid, reduced nicotinamide adenine dinucleotide phosphate oxidase, transcription factor Nrf2, unclassified drug, antioxidant activity, DPPH radical scavenging assay, drug structure, gene expression regulation, gene translocation, human, intracellular signaling, nonhuman, priority journal, protein metabolism, protein subunit, protein synthesis inhibition, protein targeting, signal transduction, 2,2-Diphenyl-1-picrylhydrazyl, NADPH-oxidase, Reactive oxygen species, unclassified drug, Oxidation-Reduction, 03 medical and health sciences, Alkaloids, Physiology (medical), medicine, Animals, Humans, Transcription factor, In vitro, 2-Diphenyl-1-picrylhydrazyl, 030104 developmental biology, Enzyme, chemistry, 030217 neurology & neurosurgery, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4769c8da49370c1f36d6e5f5ff530fTest
http://hdl.handle.net/11573/1302381Test

المؤلفون: Bengt Lindholm, Juliana Saraiva dos Anjos, Denis Fouque, Denise Mafra, Peter Stenvinkel, Ludmila F M F Cardozo, Marta Esgalhado

المساهمون: Service de néphrologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA)

المصدر: Journal of Renal Nutrition
Journal of Renal Nutrition, WB Saunders, 2018, 28 (4), pp.229-234. ⟨10.1053/j.jrn.2017.11.005⟩

مصطلحات موضوعية: 0301 basic medicine, cisplatin-induced nephrotoxicity, NF-E2-Related Factor 2, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, nrf2/ho-1 signaling pathway, Medicine (miscellaneous), cardiovascular-disease, Inflammation, Disease, Pharmacology, medicine.disease_cause, bound uremic toxins, bardoxolone methyl, 03 medical and health sciences, 0302 clinical medicine, Low-protein diet, hemodialysis-patients, nf-kappa-b, Diet, Protein-Restricted, medicine, Humans, oxidative stress, Bardoxolone methyl, Renal Insufficiency, Chronic, Transcription factor, Nutrition and Dietetics, Nutrition & Dietetics, business.industry, Urology & Nephrology, medicine.disease, NFKB1, 3. Good health, 030104 developmental biology, Nephrology, transcription factor nrf2, medicine.symptom, business, Oxidative stress, Kidney disease, chronic-renal-failure

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4b07e6ce39ec31e38e66d45bfe82c2Test
https://hal.archives-ouvertes.fr/hal-01847408Test

المؤلفون: Riet De Rycke, Kris Gevaert, Viacheslav Mylka, Lode De Cauwer, Claude Libert, Julie Deckers, Wim Vanden Berghe, Jan Tavernier, Francis Impens, Jonathan Thommis, Dariusz Ratman, Karolien De Bosscher

المصدر: Autophagy
AUTOPHAGY

مصطلحات موضوعية: 0301 basic medicine, Male, CpdA, Research Paper - Basic Science, SQSTM1/p62, Anti-Inflammatory Agents, TRANSCRIPTION FACTOR NRF2, Acetates, Dexamethasone, ACTIVATION, Mice, Glucocorticoid receptor, Sequestosome-1 Protein, ANTIOXIDANT RESPONSE, Receptor, Cells, Cultured, glucocorticoids, GLUCOCORTICOID-RECEPTOR, Cell biology, GR, Glucocorticoid, medicine.drug, Transcriptional Activation, Tyramine, Biology, MECHANISMS, 03 medical and health sciences, Receptors, Glucocorticoid, INFLAMMATION, Downregulation and upregulation, medicine, Autophagy, Gene silencing, Animals, Molecular Biology, Transcription factor, autophagy receptors, Inflammation, GENE-TRANSCRIPTION, Macrophages, NFE2L2/NRF2, Biology and Life Sciences, Cell Biology, Mice, Inbred C57BL, 030104 developmental biology, P62/SQSTM1, Nuclear receptor, Gene Expression Regulation, CELLS, Human medicine

وصف الملف: pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108c8759034d4ac931eabb3826a172c2Test
https://hdl.handle.net/10067/1541590151162165141Test

المؤلفون: García, Noemí, Zazueta, Cecilia, Aguilera-Aguirre, Leopoldo

المصدر: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)

مصطلحات موضوعية: 0301 basic medicine, Aging, Disease, reactive oxygen metabolite, medicine.disease_cause, Biochemistry, endothelial dysfunction, Diabetic nephropathy, I kappa B, Rho kinase, cyclooxygenase 2, Endothelial dysfunction, lcsh:Cytology, organ transplantation, General Medicine, Arteriosclerosis, cryopyrin, Editorial, Cardiovascular Diseases, protein degradation, medicine.symptom, down regulation, hypertension, Article Subject, dendritic cell, demethoxycurcumin, Inflammation, Protein degradation, transcription factor Nrf2, 03 medical and health sciences, inflammasome, medicine, benzyloxycarbonylleucylleucylleucinal, Animals, Humans, human, lcsh:QH573-671, arteriosclerosis, business.industry, diabetic nephropathy, Cell Biology, lycopene, medicine.disease, myocardial ischemia reperfusion injury, Oxidative Stress, proteasome, 030104 developmental biology, 7 INGENIERÍA Y TECNOLOGÍA, Proteasome, osteoprotegerin, Immunology, pathology, mitral valve prolapse, business, Oxidative stress

وصف الملف: text/xhtml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46ff4f0dab8e483f14daff729b36814Test
https://doi.org/10.1155/2017/5853238Test