نتائج البحث - "phorbol 12-myristate 13-acetate"

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 55-71 (2019)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Male, 0301 basic medicine, Cell Separation, T-Lymphocytes, Regulatory, Regulatory T Cells, Jurkat Cells, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, co-IP, co-immunoprecipitation, Phosphorylation, Original Research, IBD, inflammatory bowel disease, Janus kinase 1, biology, Chemistry, EZH2, Polycomb Repressive Complex 2, Gastroenterology, FOXP3, Forkhead Transcription Factors, H3K27me3, trimethylated histone H3 at lysine 27, hemic and immune systems, C232, cysteine 232, Middle Aged, Proinflammatory Cytokine, 3. Good health, Chromatin, Intestines, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, Female, Epigenetics, 030211 gastroenterology & hepatology, ChIP, chromatin-immunoprecipitation, JAK, Janus kinase, Co-Repressor Proteins, Protein Binding, Signal Transduction, Crohn’s Disease, Adult, STAT3 Transcription Factor, PMA, phorbol 12-myristate 13-acetate, PBMC, peripheral blood mononuclear cell, Regulatory T cell, PBS, phosphate-buffered saline, SUZ12, suppressor of zeste, Treg, regulatory T cell, chemical and pharmacologic phenomena, macromolecular substances, Proinflammatory cytokine, 03 medical and health sciences, EED, embryonic ectoderm development, CD, Crohn’s disease, medicine, Animals, Humans, LZ, leucine zipper, Enhancer of Zeste Homolog 2 Protein, lcsh:RC799-869, Phosphotyrosine, Interleukin 6, Th, T helper, Transcription factor, Janus Kinases, Cell Nucleus, Inflammation, FOXP3, forkhead domain-containing X-chromosome–encoded protein, Hepatology, Interleukin-6, PLA, proximity ligation assay, Inflammatory Bowel Diseases, WT, wild-type, IL, interleukin, Mice, Inbred C57BL, 030104 developmental biology, Mutation, IPEX, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, biology.protein, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, FCS, fetal calf serum, PRC2, polycomb repressive complex 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12e433b1850cff302bda788632ed012Test
http://www.sciencedirect.com/science/article/pii/S2352345X18301267Test

5

SNAP23 is essential for platelet and mast cell development and required in connective tissue mast cells for anaphylaxis

المؤلفون: Marco A. Ramos, Ruth Heidelberger, Roberto J. Alcazar-Felix, Roberto Adachi, Eduardo I. Cardenas, Alan R. Burns, Alejandro I. Rodarte, Ricardo Treviño González, Rodolfo A. Cardenas, Alejandro Isaza, Elizabeth Sanchez

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, CTMC, connective tissue MC, GS, series conductance, CAE, chloroacetate esterase, DNP, 2,4-dinitrophenol, CTX, cholera toxin, GTPγS, guanosine 5′-3-O-(thio)triphosphate, Biochemistry, Wsh, MC-deficient KitW-sh/W-sh mouse, Abnormal platelet morphology, Mice, Gm, membrane conductance, MC, mast cell, MMC, mucosal MC, bm, basement membrane, DT, diphtheria toxin, PCMCs, peritoneal-cell-derived MCs, BMMCs, bone-marrow-derived MCs, Platelet, Mast Cells, MFI, mean fluorescence intensity, Munc, mammalian homolog of C. elegans uncoordinated gene, Mice, Knockout, Chemistry, Degranulation, Qb-SNARE Proteins, Cm, membrane capacitance, Mast cell, humanities, Cell biology, Vesicle-associated membrane protein, medicine.anatomical_structure, F, farad, Stx, syntaxin, Connective Tissue, Pf4, platelet factor 4, SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptors, ΔCm, capacitance gain, platelets, SNAP23, AU, arbitrary units, exocytosis, Research Article, Blood Platelets, PMA, phorbol 12-myristate 13-acetate, S, siemens, SNARE proteins, FSC, forward scatter, Connective tissue, Exocytosis, 03 medical and health sciences, OVA, ovalbumin, mMCP5/Mcpt5, mouse mast cell protease 5, MOV, mean object volume, medicine, anaphylaxis, Animals, Fura-2 AM, Fura-2-acetoxymethyl ester, Qc-SNARE Proteins, Syt, synaptotagmin, Molecular Biology, 030102 biochemistry & molecular biology, SNAP23, synaptosomal-associated protein of 23 KDa, SCF, stem cell factor, Secretory Vesicles, RBL-2H3, rat basophilic leukemia cell line, Cell Biology, Cma1, chymase 1, allergy, Sv, surface density, VAMP, vesicle-associated membrane protein, 030104 developmental biology, B6, C57BL6/J mouse line, mast cell, Platelet factor 4, HSA, human serum albumin, Vv, volume density

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8204093fa71125dcdeede86da55ba3aeTest
http://europepmc.org/articles/PMC7948755Test

6

Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo

المؤلفون: Kiu Hyung Cho, Jae Gyu Park, Ebtesam M. Al-Olayan, Debasish Kumar Dey, Sukkum Ngullie Chang, Sun Chul Kang, Buyng Su Hwang, Seong Taek Oh, Won Ho Kong

المصدر: International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences, Vol 21, Iss 9261, p 9261 (2020)

مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, nuclear factor kappa-light-chain-enhancer of activated b cells (NF-κb), phorbol 12-myristate 13-acetate (PMA), Antioxidants, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Onions, lcsh:QH301-705.5, Zebrafish, Spectroscopy, Cell Line, Transformed, chemistry.chemical_classification, Chemistry, NF-kappa B, allium cepa test, General Medicine, Computer Science Applications, 030220 oncology & carcinogenesis, Toxicity, Tetradecanoylphorbol Acetate, medicine.symptom, tangeretin (TAN), Signal Transduction, Embryonic Development, Inflammation, Article, Catalysis, Congenital Abnormalities, Inorganic Chemistry, 03 medical and health sciences, In vivo, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Reactive oxygen species, Organic Chemistry, NF-κB, hypoxia-inducible factor 1-alpha (HIF-1α), Flavones, Hypoxia-Inducible Factor 1, alpha Subunit, Molecular biology, In vitro, Oxidative Stress, HaCaT, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, zebrafish embryotoxicity test, inflammation, Phorbol, Lipid Peroxidation, Epidermis, Reactive Oxygen Species, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339ddb89128337a6cd420d6bf7ee9633Test

7

Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

المؤلفون: Thorsten Maretzky, Stefan F. Lichtenthaler, Gisela Weskamp, Theresa T. Lu, Sebastien Monette, Jose Lora, Dorjee T.N. Shola, Chingwen Yang, Carl P. Blobel, Thomas M. Li

المصدر: The Journal of Biological Chemistry
The journal of biological chemistry 296, 100733-(2021). doi:10.1016/j.jbc.2021.100733

مصطلحات موضوعية: 0301 basic medicine, Male, Cytoplasm, KI, knock-in, knock-in mutation in mice, Biochemistry, Mice, iRhom1 and 2, inactive Rhomboid proteins 1 and 2, ADAM17 Protein, membrane protein, myeloid cell, MFI, mean fluorescence intensity, Receptor, Sequence Deletion, TACE (TNFα converting enzyme), Bone growth, mEF, mouse embryonic fibroblast, Chemistry, Protein Stability, ddc, Cell biology, BMDM, bone-marrow-derived macrophage, TNFα, tumor necrosis factor α, Transmembrane domain, Phenotype, Protein destabilization, ddc:540, DV, donor vector, Female, Signal transduction, metabolism [Fibroblasts], Research Article, IL-6R, interleukin-6 receptor, PMA, phorbol 12-myristate 13-acetate, genetics [ADAM17 Protein], ADAM17 (a disintegrin and metalloprotease 17), 03 medical and health sciences, metabolism [ADAM17 Protein], cell surface enzyme, Protein Domains, CHX, cycloheximide, Gene knockin, Animals, Amino Acid Sequence, Molecular Biology, metabolism [Cytoplasm], 030102 biochemistry & molecular biology, Base Sequence, Cell Biology, chemistry [ADAM17 Protein], Sheddase, Fibroblasts, EGFR, epidermal growth factor receptor, Mice, Inbred C57BL, 030104 developmental biology, EPCAM, epithelial cell adhesion molecule, mES, mouse embryonic stem, CRISPR-Cas Systems, ADAM17, a disintegrin and metalloprotease 17

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ddba9cdef79f06d77f3f2a019dddabTest
https://pubmed.ncbi.nlm.nih.gov/33957124Test

8

Novel regulation of PKC-induced inflammation by Akt and protein phosphatase 2A in ovarian granulosa cells

المؤلفون: Yuh Lin Wu, Yen Yu Lin, David Sun

المصدر: Chinese Journal of Physiology, Vol 63, Iss 4, Pp 179-186 (2020)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb15fb5ae51e583c8810aac0c9e043c2Test
https://pubmed.ncbi.nlm.nih.gov/32859885Test

9

Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity

المؤلفون: Jannis E. Meents, Clara M. Kerth, Angelika Lampert, Petra Hautvast, Jannis Körner

المصدر: J Biol Chem
The Journal of Biological Chemistry
The journal of biological chemistry : JBC 296, 100227 (2020). doi:10.1074/jbc.RA120.014288

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, alpha-Helical, Threonine, Patch-Clamp Techniques, Gene Expression, HEK, human embryonic kidney cell line, Gating, medicine.disease_cause, Erev, reversal potential, Biochemistry, Membrane Potentials, pain, Phosphorylation, Nav1.7, Protein Kinase C, Mutation, Kinase, Chemistry, protein kinase C (PKC), NAV1.7 Voltage-Gated Sodium Channel, Erythromelalgia, Recombinant Proteins, Cell biology, protein kinase A (PKA), k, slope factor, V1/2, membrane potential at half-maximal activation/inactivation, CHO-K1, Chinese hamster ovary cell line, Additions and Corrections, Chronic Pain, Ion Channel Gating, Research Article, sodium channel, Protein Binding, PMA, phorbol 12-myristate 13-acetate, Vm, membrane potential, IEM, inherited erythromelalgia, patch clamp, 03 medical and health sciences, PKC, protein kinase C, medicine, Humans, Protein Interaction Domains and Motifs, Isoleucine, Protein kinase A, Molecular Biology, Protein Kinase Inhibitors, Protein kinase C, Binding Sites, 030102 biochemistry & molecular biology, Nav, voltage-gated sodium channel, Sodium channel, Cell Biology, Diff., difference, medicine.disease, S, staurosporine, Staurosporine, CI, confidence interval, 030104 developmental biology, HEK293 Cells, Amino Acid Substitution, I848T, PKA, protein kinase A, Protein Conformation, beta-Strand, CC, calphostin C, Protein Processing, Post-Translational

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6628d415725194e0eeb9e9987d7a3aTest
https://pubmed.ncbi.nlm.nih.gov/34481319Test

10

Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

المؤلفون: Shih-Hsiang Chen, Chih-Ching Wu, Arnold Stern, Wei-Chen Yen, Hsin-Ru Lin, Daniel Tsun-Yee Chiu, Yi-Hsuan Wu, Jwu-Ching Shu

المصدر: Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)

مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Lipopolysaccharide, THP-1 Cells, Clinical Biochemistry, Interleukin-1beta, AP-1, activator protein 1, G6PD, glucose-6-phosphate dehydrogenase, p38 Mitogen-Activated Protein Kinases, Biochemistry, Inflammasome, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Bactericidal response, NOS, nitric oxide synthase, lcsh:QH301-705.5, chemistry.chemical_classification, Gene knockdown, lcsh:R5-920, NADPH oxidase, biology, Chemistry, NADPH, reduced form of nicotinamide adenine dinucleotide phosphate, NOX, NADPH oxidase, Cell biology, G6PD-kd, G6PD knockdown, PBMC, peripheral blood mononuclear cells, IL-1β, H2O2, hydrogen peroxide, Gene Knockdown Techniques, Phosphorylation, Female, lcsh:Medicine (General), Redox homeostasis, medicine.drug, Research Paper, PMA, phorbol 12-myristate 13-acetate, Adult, congenital, hereditary, and neonatal diseases and abnormalities, ATP, adenosine triphosphate, Down-Regulation, 03 medical and health sciences, Young Adult, ROS, reactive oxygen species, parasitic diseases, medicine, Humans, Aged, Reactive oxygen species, NO, nitric oxide, Innate immune system, Organic Chemistry, UP-LPS, ultrapure lipopolysaccharide, nutritional and metabolic diseases, NADPH Oxidases, Transcription Factor AP-1, 030104 developmental biology, Glucosephosphate Dehydrogenase Deficiency, HEK293 Cells, lcsh:Biology (General), MAPK, mitogen-activated protein kinases, Case-Control Studies, biology.protein, THP-1, human monocytic cells, Leukocytes, Mononuclear, Adenosine triphosphate, 030217 neurology & neurosurgery, G6PD

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b360c05a34b1841e9dee64dd83226fTest

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