Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease
| العنوان: | Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease |
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| المؤلفون: | Yueting Liang, Yingjie Zhen, Hao Chen, Peiyan Zheng, Luqian Zhou, Haisheng Hu, Teng Zhang, Zhifeng Huang, Hakon Hakonarson, Xiaohua Douglas Zhang, Runpei Lin, Baoqing Sun, Mingshan Xue, Yifeng Zeng, Hui-Qi Qu |
| المصدر: | Exp Biol Med (Maywood) |
| بيانات النشر: | SAGE Publications, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Exacerbation, Cell Respiration, Disease, Lung injury, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Original Research, Aged, COPD, Lung, business.industry, Middle Aged, medicine.disease, respiratory tract diseases, 030104 developmental biology, medicine.anatomical_structure, 030228 respiratory system, Anaerobic glycolysis, Metabolome, Female, business, Glycolysis, Anaerobic exercise |
| الوصف: | While there is no cure for chronic obstructive pulmonary disease (COPD), its progressive nature and the formidable challenge to manage its symptoms warrant a more extensive study of the pathogenesis and related mechanisms. A new emphasis on COPD study is the change of energy metabolism. For the first time, this study investigated the anaerobic and aerobic energy metabolic pathways in COPD using the metabolomic approach. Metabolomic analysis was used to investigate energy metabolites in 140 COPD patients. The significance of energy metabolism in COPD was comprehensively explored by the Global Initiative for Chronic Obstructive Lung Disease–GOLD grading, acute exacerbation vs. stable phase (either clinical stability or four-week stable phase), age group, smoking index, lung function, and COPD Assessment Test (CAT) score. Through comprehensive evaluation, we found that COPD patients have a significant imbalance in the aerobic and anaerobic energy metabolisms in resting state, and a high tendency of anaerobic energy supply mechanism that correlates positively with disease progression. This study highlighted the significance of anaerobic and low-efficiency energy supply pathways in lung injury and linked it to the energy-inflammation-lung ventilatory function and the motion limitation mechanism in COPD patients, which implies a novel therapeutic direction for this devastating disease. |
| تدمد: | 1535-3699 1535-3702 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a534d0192b6afd08e02507583f724aTest https://doi.org/10.1177/15353702211008808Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a7a534d0192b6afd08e02507583f724a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15353699 15353702 |
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