نتائج البحث - "Peter J. Mullen"

1

A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer

المؤلفون: Najia Khurram, Peter J. Mullen, Robert J. Hamilton, Sangeet Ghai, Mohamad Elbaz, Joseph Longo, Theodorus van der Kwast, Emily Branchard, Neil Fleshner, Mehdi Masoomian, Linda Z. Penn, Eric Chen, Karen Hersey, Dianne Chadwick, David W. Andrews

المصدر: Prostate Cancer and Prostatic Diseases

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Cancer therapy, Urology, medicine.medical_treatment, Apoptosis, Pilot Projects, Article, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, Preoperative Care, Biopsy, Biomarkers, Tumor, medicine, Humans, Fluvastatin, Aged, Prostatectomy, medicine.diagnostic_test, Caspase 3, business.industry, Prostatic Neoplasms, Middle Aged, medicine.disease, Neoadjuvant Therapy, 3. Good health, Ki-67 Antigen, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Immunohistochemistry, Hydroxymethylglutaryl CoA Reductases, business, medicine.drug, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928230d134347a4cfd7a1d049f2ee4c2Test
https://doi.org/10.1038/s41391-020-0221-7Test

2

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

المؤلفون: Nedas Matulionis, Peter J. Mullen, Arunachalam Ramaiah, Chandani Sen, Samuel W. French, Vaithilingaraja Arumugaswami, Ernst W. Schmid, Robert Damoiseaux, Kathrin Plath, Milica Momcilovic, Brigitte N. Gomperts, David B. Shackelford, Arunima Purkayastha, Gustavo Garcia, Justin Langerman, Heather R. Christofk

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature communications, vol 12, iss 1

مصطلحات موضوعية: 0301 basic medicine, viruses, Glutamine, General Physics and Astronomy, mTORC1, Virus Replication, 0302 clinical medicine, Chlorocebus aethiops, 2.1 Biological and endogenous factors, Aetiology, skin and connective tissue diseases, Lung, Multidisciplinary, respiratory system, Pyruvate carboxylase, Cell biology, Infectious Diseases, Mechanisms of disease, 5.1 Pharmaceuticals, TOR signalling, Benzamides, Respiratory, Mucosal immunology, Development of treatments and therapeutic interventions, Infection, Science, Morpholines, Citric Acid Cycle, Biology, Mechanistic Target of Rapamycin Complex 1, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Animals, Humans, Naphthyridines, Protein Kinase Inhibitors, Vero Cells, Pyruvate Carboxylase, SARS-CoV-2, HEK 293 cells, COVID-19, Pneumonia, General Chemistry, Metabolism, biochemical phenomena, metabolism, and nutrition, respiratory tract diseases, 030104 developmental biology, Glucose, HEK293 Cells, Pyrimidines, Viral replication, Cell culture, Viral infection, Vero cell, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac75753ea6cfdc1e6711e570eefe016eTest
https://pubmed.ncbi.nlm.nih.gov/33767183Test

3

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

المؤلفون: Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Wail Ba-alawi, Joseph Longo, Linda Z. Penn, Benjamin Haibe-Kains

المصدر: Cancer Research. 78:1347-1357

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Epithelial-Mesenchymal Transition, Statin, medicine.drug_class, Protein Prenylation, Farnesyl pyrophosphate, Mevalonic Acid, Apoptosis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Polyisoprenyl Phosphates, Prenylation, Neoplasms, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Humans, HRAS, Fluvastatin, Cell Proliferation, Zinc Finger E-box-Binding Homeobox 1, 3. Good health, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, ras Proteins, Cancer research, Protein prenylation, lipids (amino acids, peptides, and proteins), Ras superfamily, Sesquiterpenes, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172d0af6f57cd0142de641e82bd842fdTest
https://doi.org/10.1158/0008-5472.can-17-1231Test

4

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

المؤلفون: David B. Shackelford, Steven D. Mittelman, Ernst W. Schmid, Peter J. Mullen, Milica Momcilovic, Simon R.V. Knott, Abigail S. Krall, Apisadaporn Thambundit, Heather R. Christofk, Felicia Surjono, Costas A. Lyssiotis, Christopher J. Halbrook

المصدر: Cell metabolism, vol 33, iss 5

مصطلحات موضوعية: 0301 basic medicine, Physiology, cancer metabolism, mTORC1, Medical Biochemistry and Metabolomics, Mice, chemistry.chemical_compound, 0302 clinical medicine, Mice, Inbred NOD, Neoplasms, Asparagine, Cancer, Tumor, Nucleotides, Chemistry, asparagine, Metformin, Mitochondria, Survival Rate, Biochemistry, Intracellular, Asparaginase, Context (language use), Mechanistic Target of Rapamycin Complex 1, cancer treatment, Cell Line, Endocrinology & Metabolism, 03 medical and health sciences, Cell Line, Tumor, Respiration, Animals, Humans, Molecular Biology, Cell Proliferation, Aspartic Acid, Cell growth, ATF4, dietary restriction, Cell Biology, asparaginase, Activating Transcription Factor 4, Diet, 030104 developmental biology, Electron Transport Chain Complex Proteins, Inbred NOD, Biochemistry and Cell Biology, respiration, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ff698e1ed01342f983891c97c95357Test
https://doi.org/10.1016Test/j.cmet.2021.02.001

5

The interplay between cell signalling and the mevalonate pathway in cancer

المؤلفون: Peter J. Mullen, Rosemary Yu, Michael C. Archer, Joseph Longo, Linda Z. Penn

المصدر: Nature Reviews Cancer. 16:718-731

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44579fb2e893e634174ba9ab66ffe337Test
https://doi.org/10.1038/nrc.2016.76Test

6

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

المؤلفون: Eric Chen, Mehdi Masoomian, Peter J. Mullen, Joan Sweet, Theodorus van der Kwast, Joseph Longo, Neil E. Fleshner, Rosemary Yu, Linda Z. Penn, Jenna E. van Leeuwen, Yuzhuo Wang, Robert J. Hamilton, Dixon T.S. Woon

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 25, Iss, Pp 119-130 (2019)

مصطلحات موضوعية: 0301 basic medicine, Male, Mevalonate pathway, Drug repurposing, Apoptosis, Mice, SCID, Prostate cancer, Mice, 0302 clinical medicine, Mice, Inbred NOD, Medicine, Dipyridamole, 3. Good health, Sterols, lipids (amino acids, peptides, and proteins), Original Article, medicine.drug, Sterol Regulatory Element Binding Protein 2, lcsh:Internal medicine, Programmed cell death, Statin, medicine.drug_class, Cell Survival, Mevalonic Acid, 030209 endocrinology & metabolism, Antineoplastic Agents, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Animals, Viability assay, lcsh:RC31-1245, Fluvastatin, Molecular Biology, Tumor metabolism, business.industry, Drug Repositioning, Statins, Prostatic Neoplasms, Cell Biology, medicine.disease, Lipid Metabolism, Xenograft Model Antitumor Assays, Sterol regulatory element-binding protein, 030104 developmental biology, Cancer research, Hydroxymethylglutaryl CoA Reductases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2157c71470c4e70e8e94eed012f71aTest
https://pubmed.ncbi.nlm.nih.gov/31023626Test

7

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

المؤلفون: William J. Sullivan, Milica Momcilovic, Daniel Braas, Utpal Banerjee, Andrew E. Whiteley, Ernst W. Schmid, David Jelinek, William E. Lowry, Peter J. Mullen, Matthew B. Maxwell, Mark S. Sharpley, Hilary A. Coller, Donald E. Ayer, David B. Shackelford, Thomas Q. de Aguiar Vallim, Blake R. Wilde, Aimee Flores, Heather R. Christofk

المصدر: Cell, vol 175, iss 1

مصطلحات موضوعية: 0301 basic medicine, cell migration, extracellular matrix, glucose metabolism, 1.1 Normal biological development and functioning, Hyaluronoglucosaminidase, hyaluronidase, Biology, Medical and Health Sciences, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, receptor tyrosine kinase signaling, Extracellular matrix, 03 medical and health sciences, Tristetraprolin, Underpinning research, Cell Line, Tumor, cell biology, Humans, Glycolysis, Hyaluronic Acid, ZFP36, Cancer, Glucose Transporter Type 1, Tumor, Glucose transporter, Cell migration, Biological Sciences, Cell biology, Extracellular Matrix, 030104 developmental biology, Glucose, GLUT1 trafficking, mRNA degradation, biology.protein, Intercellular Signaling Peptides and Proteins, Carbohydrate Metabolism, GLUT1, Signal transduction, Carrier Proteins, TXNIP, Signal Transduction, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c96199e1b89ffdcbcc9314a9aa530bTest
https://escholarship.org/uc/item/3x99h8gqTest

8

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

المؤلفون: Peter J. Mullen, Ahmed Aman, Linda Z. Penn, Benjamin Haibe-Kains, Aaliya Tamachi, Wail Ba-alawi, Rima Al-awar, David W. Cescon, Cornelia Redel, Cheryl H. Arrowsmith, Yu-Jia Shiah, Dharmendra Dingar, Brian Raught, William B. Tu, Corey Lourenco, Paul C. Boutros

المصدر: Cancer cell. 34(4)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f0fd34332be5f88813a6d939006c6aTest
https://pubmed.ncbi.nlm.nih.gov/30367118Test

9

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

المؤلفون: Peter J. Mullen, Stephan Krähenbühl, Luiz Carlos Carvalho Navegantes, Ileana Scurtu Mityko, Jamal Bouitbir, Annalisa Bonifacio

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Simvastatin, Time Factors, Health, Toxicology and Mutagenesis, Muscle Proteins, Apoptosis, Biology, AMP-Activated Protein Kinases, Toxicology, Mitochondria, Heart, Cell Line, Dephosphorylation, 03 medical and health sciences, Adenosine Triphosphate, In vivo, Internal medicine, medicine, Animals, Myocytes, Cardiac, PROTEÍNAS MUSCULARES, Phosphorylation, Membrane Potential, Mitochondrial, SKP Cullin F-Box Protein Ligases, Dose-Response Relationship, Drug, Forkhead Box Protein O3, AMPK, Skeletal muscle, Forkhead Transcription Factors, General Medicine, Cardiotoxicity, Rats, Up-Regulation, Enzyme Activation, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Electron Transport Chain Complex Proteins, Toxicity, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Energy Metabolism, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3154f2a622ef7fdfea2810a04d9f3349Test
https://pubmed.ncbi.nlm.nih.gov/25300705Test

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