Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass
| العنوان: | Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass |
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| المؤلفون: | Isabella Jonsson, Kirstine N. Bojsen-Møller, Viggo B. Kristiansen, Simon Veedfald, Nicolai J. Wewer Albrechtsen, Trine R. Clausen, Rune E. Kuhre, Jens F. Rehfeld, Jens J. Holst, Sten Madsbad, Maria S. Svane |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) Jonsson, I, Bojsen-Moller, K N, Kristiansen, V B, Veedfald, S, Albrechtsen, N J W, Clausen, T R, Kuhre, R E, Rehfeld, J F, Holst, J J, Madsbad, S & Svane, M S 2021, ' Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass ', Frontiers in Endocrinology, vol. 12, 681116 . https://doi.org/10.3389/fendo.2021.681116Test |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Roux-en-Y gastric bypass, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Colesevelam Hydrochloride, Gastric Bypass, 030209 endocrinology & metabolism, Carbohydrate metabolism, Glucagon, Diseases of the endocrine glands. Clinical endocrinology, Bile Acids and Salts, 03 medical and health sciences, chemistry.chemical_compound, Endocrinology, 0302 clinical medicine, RYGB, Chenodeoxycholic acid, Internal medicine, medicine, Humans, Single-Blind Method, Neurotensin, Original Research, bile acids, colesevelam, C-Peptide, Bile acid, Chemistry, Colesevelam, digestive, oral, and skin physiology, Glucagon secretion, Middle Aged, RC648-665, Postprandial Period, glucagon-like peptide 1, Obesity, Morbid, Glucose, 030104 developmental biology, Postprandial, Female, Blood sugar regulation, medicine.drug |
| الوصف: | BackgroundAltered bile acid (BA) turnover has been suggested to be involved in the improved glucose regulation after Roux-en-Y gastric bypass (RYGB), possibly via stimulation of GLP-1 secretion. We investigated the role of exogenous as well as endogenous BAs for GLP-1 secretion after RYGB by administering chenodeoxycholic acid (CDCA) and the BA sequestrant colesevelam (COL) both in the presence and the absence of a meal stimulus.MethodsTwo single-blinded randomized cross-over studies were performed. In study 1, eight RYGB operated participants ingested 200 ml water with 1) CDCA 1.25 g or 2) CDCA 1.25 g + colesevelam 3.75 g on separate days. In study 2, twelve RYGB participants ingested on separate days a mixed meal with addition of 1) CDCA 1.25 g, 2) COL 3.75 g or 3) COL 3.75 g × 2, or 4) no additions.ResultsIn study 1, oral intake of CDCA increased circulating BAs, GLP-1, C-peptide, glucagon, and neurotensin. Addition of colesevelam reduced all responses. In study 2, addition of CDCA enhanced meal-induced increases in plasma GLP-1, glucagon and FGF-19 and lowered plasma glucose and C-peptide concentrations, while adding colesevelam lowered circulating BAs but did not affect meal-induced changes in plasma glucose or measured gastrointestinal hormones.ConclusionIn RYGB-operated persons, exogenous CDCA enhanced meal-stimulated GLP-1 and glucagon secretion but not insulin secretion, while the BA sequestrant colesevelam decreased CDCA-stimulated GLP-1 secretion but did not affect meal-stimulated GLP-1, C-peptide or glucagon secretion, or glucose tolerance. These findings suggest a limited role for endogenous bile acids in the acute regulation of postprandial gut hormone secretion or glucose metabolism after RYGB. |
| وصف الملف: | application/pdf |
| تدمد: | 1664-2392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01d868c62a415b8b9034570417ea99aTest https://doi.org/10.3389/fendo.2021.681116Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d01d868c62a415b8b9034570417ea99a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
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