نتائج البحث - "Glucagon-Like Peptide-1 Receptor"

1

GLP-1 peptide analogs for targeting pancreatic beta cells

المؤلفون: Seyed Ebrahim Alavi, Hasan Ebrahimi Shahmabadi

المصدر: Drug Discovery Today. 26:1936-1943

مصطلحات موضوعية: 0301 basic medicine, endocrine system, Peptide, Disease, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Diabetes mellitus, Drug Discovery, Diabetes Mellitus, Animals, Humans, Hypoglycemic Agents, Insulin, Medicine, Receptor, Pharmacology, chemistry.chemical_classification, biology, business.industry, digestive, oral, and skin physiology, medicine.disease, Glucagon-like peptide-1, Insulin receptor, Glucose, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Drug delivery, Cancer research, biology.protein, Beta cell, business, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876b63ff2ae83bdb02da4773765b4da4Test
https://doi.org/10.1016/j.drudis.2021.03.032Test

2

Activation of overexpressed glucagon‐like peptide‐1 receptor attenuates prostate cancer growth by inhibiting cell cycle progression

المؤلفون: Masatoshi Tanaka, Tomoko Tanaka, Daiji Kawanami, Takako Kawanami, Takashi Nomiyama, Shinichiro Irie, Ryoko Motonaga, Kazuki Nabeshima, Nobuya Hamanoue, Yuriko Hamaguchi, Makito Tanabe, Tsuyoshi Horikawa, Toru Shigeoka, Toshihiko Yanase

المصدر: Journal of Diabetes Investigation, Vol 11, Iss 5, Pp 1137-1149 (2020)
Journal of Diabetes Investigation

مصطلحات موضوعية: Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Apoptosis, Mice, Prostate cancer, 0302 clinical medicine, Tumor Cells, Cultured, Medicine, Receptor, Aged, 80 and over, medicine.diagnostic_test, digestive, oral, and skin physiology, Articles, General Medicine, Middle Aged, Cell cycle, Prognosis, Gene Expression Regulation, Neoplastic, Real-time polymerase chain reaction, Original Article, Glucagon‐like peptide‐1 receptor, hormones, hormone substitutes, and hormone antagonists, Adult, Basic Science and Research, endocrine system, Mice, Nude, 030209 endocrinology & metabolism, Glucagon-Like Peptide-1 Receptor, Diseases of the endocrine glands. Clinical endocrinology, Flow cytometry, Young Adult, 03 medical and health sciences, In vivo, Biomarkers, Tumor, Internal Medicine, Animals, Humans, Aged, Cell Proliferation, business.industry, Cell growth, Prostatic Neoplasms, Cancer, medicine.disease, RC648-665, Xenograft Model Antitumor Assays, 030104 developmental biology, Cancer research, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b206b93d5bd5e14e7fa0638780ac368Test
https://doaj.org/article/46b73efe4bc4460ab61d39d90ff1417dTest

3

A quinoxaline-based compound ameliorates bone loss in ovariectomized mice

المؤلفون: Fen Li, Xiaoyan Xue, Zheng Hou, Zhou Chen, Ying Zhou, Yanyan Guo, Huan Liu, Ning Wang, Yang Wang

المصدر: Exp Biol Med (Maywood)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e852ac7d0f92c81482e781653e9ffeTest
https://doi.org/10.1177/15353702211032133Test

4

The diverse effects of brain glucagon‐like peptide 1 receptors on ingestive behaviour

المؤلفون: Diana L. Williams

المصدر: Br J Pharmacol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e65d6b621633f825971af17a5413503Test
https://doi.org/10.1111/bph.15535Test

5

Effects of glucagon‐like peptide‐1 receptor agonists on secretions of insulin and glucagon and gastric emptying in Japanese individuals with type 2 diabetes: A prospective, observational study

المؤلفون: Yuichiro Yamada, Kenta Murotani, Yusuke Seino, Yutaka Seino, Minori Ishitobi, Yuji Yamazaki, Yuuka Fujiwara, Ryota Usui, Yoshiyuki Hamamoto, Hitoshi Kuwata, Sodai Kubota, Daisuke Yabe, Takeshi Kurose, Takuya Haraguchi, Saki Kubota-Okamoto

المصدر: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2162-2171 (2021)

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glucagon-Like Peptides, Gastric emptying, Type 2 diabetes, chemistry.chemical_compound, 0302 clinical medicine, Japan, Insulin, Prospective Studies, digestive, oral, and skin physiology, Articles, General Medicine, Middle Aged, Postprandial Period, Clinical Science and Care, Postprandial, GLP‐1 receptor agonist, Female, Original Article, hormones, hormone substitutes, and hormone antagonists, medicine.drug, Adult, endocrine system, medicine.medical_specialty, Recombinant Fusion Proteins, 030209 endocrinology & metabolism, Gastric Inhibitory Polypeptide, Diseases of the endocrine glands. Clinical endocrinology, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Lixisenatide, Internal medicine, islet hormones, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Glucagon-like peptide 1 receptor, Liraglutide, business.industry, RC648-665, Glucagon, medicine.disease, Immunoglobulin Fc Fragments, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, chemistry, Dulaglutide, Apolipoprotein B-48, Peptides, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306175bf3a5c32c1eda622a58314861dTest
https://doi.org/10.1111/jdi.13598Test

6

Normalisation of glucose metabolism by exendin‐4 in the chronic phase after stroke promotes functional recovery in male diabetic mice

المؤلفون: Vladimer Darsalia, Dimitra Karampatsi, Martin Larsson, Doortje Dekens, Gesine Paul, Thomas Nyström, Osama Elabi, Alexander Zabala, Ingrid Lovise Augestad, Cesare Patrone, Hiranya Pintana

المصدر: British Journal of Pharmacology. 179:677-694

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, Agonist, endocrine system, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Type 2 diabetes, Brain damage, Vascular Remodeling, Glucagon-Like Peptide-1 Receptor, Diabetes Mellitus, Experimental, Vascular remodelling in the embryo, Cicatrix, Mice, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Internal medicine, medicine, Animals, Stroke, Neuroinflammation, Pharmacology, business.industry, Infarction, Middle Cerebral Artery, medicine.disease, Parvalbumins, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Exenatide, Insulin Resistance, medicine.symptom, business, Stroke recovery, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83c8d733941302459781a26c7932715Test
https://doi.org/10.1111/bph.15524Test

7

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

المؤلفون: Lei Zhao, Xinyi Chen, Ho Ko, Joaquim S. L. Vong, Yun Kwok Wing, Junzhe Huang, Vincent Mok, Zhongqi Li, Bonaventure Ip, Leo Y. C. Yan, Hei-Ming Lai

المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Communications Biology

مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Cell type, Aging, endocrine system, medicine.drug_class, QH301-705.5, Parkinson's disease, Cell, Medicine (miscellaneous), Biology, General Biochemistry, Genetics and Molecular Biology, Mural cell, Glucagon-Like Peptide-1 Receptor, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Alzheimer Disease, medicine, Animals, Humans, Biology (General), Receptor, Cellular Senescence, Microglia, Cognitive ageing, Neurodegeneration, Brain, Neurodegenerative Diseases, Alzheimer's disease, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Exenatide, Feasibility Studies, General Agricultural and Biological Sciences, Transcriptome, Astrocyte, Neuroscience, Neuroglia, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca8396ea1965a9b468ab96057e62976Test
https://doaj.org/article/b6e03838a0f54cd39260f2154383d3c8Test

8

GLP-1 (Glucagon-Like Peptide-1) Is Physiologically Relevant for Chylomicron Secretion Beyond Its Known Pharmacological Role

المؤلفون: Lili Tian, Avital Nahmias, Priska Stahel, Gary F. Lewis, Changting Xiao

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 41:1893-1900

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c547a2c51a5cbd7fb85d181ac153d5d6Test
https://doi.org/10.1161/atvbaha.121.316311Test

9

GPCRs: The most promiscuous druggable receptor of the mankind

المؤلفون: F Al-Zoghaibi, Asma S.A. Alonazi, Asim Azhar, Khaled A. Al-Hosaini

المصدر: Saudi Pharmaceutical Journal : SPJ
Saudi Pharmaceutical Journal, Vol 29, Iss 6, Pp 539-551 (2021)

مصطلحات موضوعية: 0301 basic medicine, ERK, Extracellular signal-Regulated Kinase, cAMP, cyclic AMP, G protein, CCR, Chemokine Receptor, GLP1R, Glucagon-Like Peptide-1 Receptor, Druggability, Heterodimerization, Pharmaceutical Science, RM1-950, Review, Computational biology, COX, Cyclooxygenase, Biology, GRKs, AC, Adenylyl Cyclase, 03 medical and health sciences, GPCR, 0302 clinical medicine, DAG, Diacylglycerol, Arrestin, PKA, Protein Kinase A, PIP2, Phosphatidylinositol-4,5-bisphosphate, Receptor, Gene, GRKs, G protein-coupled Receptor Kinases, G protein-coupled receptor, Pharmacology, G protein-coupled receptor kinase, NMDA, N-Methyl D-Aspartate, Drugs, Nbs, Nanobodies, MAPK, Mitogen-Activated Protein Kinase, Signaling, 030104 developmental biology, PAR-1, Protease Activated Receptor 1, Therapeutics. Pharmacology, IP3, Inositol 1,4,5-triphosphate, GIP, Gastric Inhibitory Peptide, 030217 neurology & neurosurgery, Function (biology), G proteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14339e0def5699befb4d16ab07f7bd41Test
https://doi.org/10.1016/j.jsps.2021.04.015Test

10

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

المؤلفون: Xianqiang Sun, Qingtong Zhou, Antao Dai, Honglei Ma, Yan Zhang, Qing Liu, Wenge Zhong, Tian Xia, Xi Wang, Wei Huang, Zhaotong Cong, Li-Nan Chen, Xinyu Zou, Peiyu Xu, Ming-Wei Wang, Dehua Yang, H. Eric Xu, Lihua Zhao, Chenyu Ye

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Agonist, endocrine system, Protein Conformation, G protein, medicine.drug_class, Science, Allosteric regulation, Glucagon-Like Peptides, General Physics and Astronomy, CHO Cells, macromolecular substances, Molecular Dynamics Simulation, Spodoptera, General Biochemistry, Genetics and Molecular Biology, Glucagon-Like Peptide-1 Receptor, Article, Cell Line, 03 medical and health sciences, Computational biophysics, 0302 clinical medicine, Protein structure, Cricetulus, G protein-coupled receptors, Receptor pharmacology, Glucagon-Like Peptide 1, Heterotrimeric G protein, Sf9 Cells, medicine, Animals, Humans, Binding site, Receptor, Enhancer, Multidisciplinary, Binding Sites, Chemistry, Cryoelectron Microscopy, digestive, oral, and skin physiology, General Chemistry, Small molecule, Enzyme Activation, 030104 developmental biology, HEK293 Cells, Diabetes Mellitus, Type 2, Biophysics, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0481bdd863aed3f64acc5050b5a6f169Test
https://doaj.org/article/092caffa900241a1b25c21698353ff0dTest

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