Salivary gland proteins alterations in the diabetic milieu
| العنوان: | Salivary gland proteins alterations in the diabetic milieu |
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| المؤلفون: | Lavinia Giovanna Leone, Abdo Jurjus, Giovanni Tomasello, Malak Fouani, Angelo Leone, Charbel A. Basset |
| المساهمون: | Fouani, M, Basset, CA, Jurjus, AR, Leone, LG, Tomasello, G, Leone, A |
| المصدر: | Journal of Molecular Histology |
| بيانات النشر: | Springer Netherlands, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Settore BIO/17 - Istologia, 0301 basic medicine, Exocrine gland, Histology, Physiology, Saliva secretion, Muscarinic receptors, Context (language use), Salivary glands, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, stomatognathic system, Medicine, Animals, Humans, Salivary Proteins and Peptides, Periodontitis, Review Paper, Salivary gland, business.industry, 030206 dentistry, Cell Biology, General Medicine, medicine.disease, Pathophysiology, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Screening, business, Homeostasis, Biomarkers |
| الوصف: | Salivary glands are considered the chief exocrine glands of the mouth and physiologically contribute to the maintenance of the homeostasis of the oral cavity. They consist of the parotid, submandibular and sublingual glands, which come in pairs and are collectively called the major glands, and the minor glands, which are much smaller and are dispersed throughout the buccal cavity. Salivary glands are distinguished by their size, amount of saliva secretion and their location in the oral cavity. Salivary glands pathophysiology has been a subject of interest in various worldwide metabolic disorders, including diabetes mellitus. Diabetes mellitus (DM), a global health concern, with a pathological imprint involved in vasculature, promotes microvascular and macrovascular complications among which periodontitis ranks sixth. Indeed, DM has also been directly associated with oral health lesions. Specifically, salivary glands in the context of diabetes have been a focal point of study and emphasis in the research field. There is evidence that relates salivary secretion content and diabetes progression. In this review, we present all the reported evidence of the deregulation of specific salivary proteins associated with the progression of diabetes in parallel with changes in salivary gland morphology, cellular architecture, and salivary secretion and composition more generally. |
| اللغة: | English |
| تدمد: | 1567-2387 1567-2379 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2ad4201eb23b4295310d0b0b1b405fTest http://europepmc.org/articles/PMC8487876Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4a2ad4201eb23b4295310d0b0b1b405f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15672387 15672379 |
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