Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomas
| العنوان: | Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomas |
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| المؤلفون: | Caterina Longo, Maria Concetta Fargnoli, Claudia Martorelli, Gianluca Cipolloni, Elvira Moscarella, Ambra Antonini, Roberto Alfano, Giuseppe Argenziano, Alessia Ciarrocchi, Cristina Pellegrini, Marco Manfredini, Emi Dika, Ketty Peris, Riccardo Pampena |
| المساهمون: | Moscarella E., Pellegrini C., Pampena R., Argenziano G., Manfredini M., Martorelli C., Ciarrocchi A., Dika E., Peris K., Antonini A., Cipolloni G., Alfano R., Longo C., Fargnoli M.C., Moscarella, Elvira, Pellegrini, Cristina, Pampena, Riccardo, Argenziano, Giuseppe, Manfredini, Marco, Martorelli, Claudia, Ciarrocchi, Alessia, Dika, Emi, Peris, Ketty, Antonini, Ambra, Cipolloni, Gianluca, Alfano, Roberto, Longo, Caterina, Fargnoli, Maria Concetta |
| المصدر: | Experimental dermatology. 28(7) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Adult, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Skin Neoplasms, molecular analyse, Adolescent, Concordance, DNA Mutational Analysis, Dermoscopy, Dermatology, Independent predictor, Biochemistry, BRAF, DNA Mutational Analysi, 030207 dermatology & venereal diseases, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Similarity (network science), Retrospective Studie, molecular analyses, Internal medicine, medicine, Mutational status, Humans, Statistical analysis, Skin Neoplasm, neoplasms, Molecular Biology, Melanoma, Aged, Retrospective Studies, dermoscopy, multiple primary melanomas, multiple primary melanoma, business.industry, High-Throughput Nucleotide Sequencing, Middle Aged, 030104 developmental biology, Tissue sections, Female, Settore MED/35 - MALATTIE CUTANEE E VENEREE, business, Human |
| الوصف: | Background The association of clinical and dermoscopic features with BRAF mutational status has been poorly analysed in multiple primary melanomas (MPM). Objective To investigate whether concordance of BRAF mutational status is associated with dermoscopic similarity in multiple melanomas of the same patient. Methods Dermoscopic images and corresponding tissue sections of 124 melanomas from 62 patients with MPM were selected at four Italian Dermatology Departments. Similarity of dermoscopic appearance between multiple melanomas was evaluated according to the presence of the same prevalent dermoscopic feature. The BRAFV600 mutational status was analysed with allele-specific TaqManTM assays or pyrosequencing. Spearman's correlation and univariate and multivariate regression analysis were used for statistical analysis. Results A similar dermoscopic appearance was identified in 38.7% (24/62) of patients with MPM and was correlated with older age at first diagnosis (rho: 0.26; P: 0.042) and occurrence on sun-damaged skin (rho: 0.27; P: 0.037). The BRAFV600 mutation was detected in 39.5% (49/124) of the tumors and a concordant BRAF mutational status between melanomas in 33/62 (53.2%) MPM patients. Dermoscopically similar melanomas showed 5.7-fold higher odds to be concordant for BRAF mutational status compared to dissimilar lesions (OR: 5.7; 95% CI 1.7-19.5; P: 0.005). Conclusion Dermoscopic similarity of multiple melanomas represents an independent clinical predictor of a concordant BRAF mutational status in MPM patients. |
| وصف الملف: | ELETTRONICO; STAMPA |
| تدمد: | 1600-0625 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd55216c61671e8a98d43c00dae94560Test https://pubmed.ncbi.nlm.nih.gov/31034104Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd55216c61671e8a98d43c00dae94560 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000625 |
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