نتائج البحث

1

Reduction of endoglin receptor impairs mononuclear cell-migration

المؤلفون: Marie E. Faughnan, Dewi Clark, Zhengda Sun, Hua Su, Zhenying Han, Sonali Shaligram

المصدر: Exploration of Medicine, Vol 1, Iss 3, Pp 136-148 (2020)
Exploration of medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c74b8f0b2e9643b915841f7c1569d30Test
https://www.explorationpub.com/Journals/em/Article/100110Test

2

Future treatments for hereditary hemorrhagic telangiectasia

المؤلفون: Sabine Bailly, Sophie Dupuis-Girod, Jean-Jacques Feige, Florian Robert, Agnès Desroches-Castan

المساهمون: Famille BMP dans l'angiogenèse et la lymphangiogenèse (BAL ), Biologie du Cancer et de l'Infection (BCI ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Pédiatrie hospices civils de Lyon, Hôpital Femme-Mère-Enfant, centre national de référence pour la maladie de Rendu-Osler

المصدر: Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-10 (2020)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, 2020, 15 (1), pp.4. ⟨10.1186/s13023-019-1281-4⟩

مصطلحات موضوعية: 0301 basic medicine, Bone morphogenetic protein signaling, [SDV]Life Sciences [q-bio], Vascular malformations, lcsh:Medicine, Disease, Review, ALK1, 030204 cardiovascular system & hematology, Tacrolimus, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, High throughput screening, Medicine, Humans, Pharmacology (medical), Bone morphogenetic protein receptor, Telangiectasia, Genetics (clinical), Smad4 Protein, business.industry, Drug repositioning, lcsh:R, ACVRL1, General Medicine, Endoglin, High-Throughput Screening Assays, Vascular endothelial growth factor, Bevacizumab, 030104 developmental biology, chemistry, Hereditary hemorrhagic telangiectasia, Vascular Disorder, Cancer research, Telangiectasia, Hereditary Hemorrhagic, medicine.symptom, business, Rare disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0854ac2f923994ea782e04613909b0fcTest
https://doaj.org/article/58e4a05c1ce9485e874117ded0f49af4Test

3

Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn’s Disease

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 779-796 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, SES-CD, Simple Endoscopic Score for Crohn's Disease, Activin Receptors, Type II, E2F2, E2F Transcription Factor 2, ALK1, EM, expansion media, Inflammatory bowel disease, IEC, intestinal epithelial cell, 0302 clinical medicine, Crohn Disease, Intestinal Epithelial Barrier, miRNA, microRNA, Intestinal Mucosa, miR-31, Original Research, TGF-β, transforming growth factor β, Crohn's disease, Kinase, Gastroenterology, Middle Aged, mRNA, messenger RNA, mir-31, UTR, untranslated region, medicine.anatomical_structure, Real-time polymerase chain reaction, NIBD, noninflammatory bowel disease, qPCR, quantitative polymerase chain reaction, Female, 030211 gastroenterology & hepatology, Adult, Colon, Down-Regulation, DM, differentiation medium, digestive system, TEER, transepithelial electrical resistance, 03 medical and health sciences, CD, Crohn’s disease, medicine, Humans, lcsh:RC799-869, Reporter gene, Hepatology, business.industry, Inflammatory Bowel Disease, HBSS, Hank’s balanced salt solution, BMP, bone morphogenetic protein, ACVRL1, medicine.disease, digestive system diseases, Epithelium, Enzyme Activation, MicroRNAs, 030104 developmental biology, 2D, 2-dimensional, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, EdU, 5-ethynyl-2-deoxyuridine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa594418120dcc1e515ea163c043dc9Test
https://doi.org/10.1016/j.jcmgh.2020.06.005Test

4

Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice

المؤلفون: Zhengda Sun, Sen Wang, Wan Zhu, Hua Su, Daniel Saw, Sonali Shaligram, Miriam Weiss, Meng Wei

المصدر: Translational stroke research, vol 10, iss 5
Transl Stroke Res

مصطلحات موضوعية: Male, 0301 basic medicine, Somatic cell, Activin Receptors, Type II, Activin Receptors, Gene Expression, Alk1, Gene mutation, Inbred C57BL, Pathogenesis, Mice, Exon, 0302 clinical medicine, 2.1 Biological and endogenous factors, CRISPR, Medicine, Aetiology, Cas9, General Neuroscience, Neurological, Public Health and Health Services, Female, Development of treatments and therapeutic interventions, Cardiology and Cardiovascular Medicine, Biotechnology, Intracranial Arteriovenous Malformations, Genetic Vectors, Clinical Sciences, Somatic gene mutation, Type II, Article, Viral vector, 03 medical and health sciences, Genetics, Animals, CRISPR/Cas9, Gene, 5.2 Cellular and gene therapies, Animal, business.industry, Brain arteriovenous malformation, Neurosciences, Endothelial Cells, Molecular biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Disease Models, Mutation, Neurology (clinical), CRISPR-Cas Systems, business, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ef6cb566736442d8564b14aeaebd85Test
https://doi.org/10.1007/s12975-018-0676-1Test

5

Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer

المؤلفون: Mattias Höglund, David Lindgren, Michael Bartoschek, Nour Al Dain Marzouka, Ewa Kurzejamska, Matteo Bocci, Jonas Sjölund, Kristian Pietras

المصدر: Angiogenesis

مصطلحات موضوعية: Male, 0301 basic medicine, Cell signaling, Cancer Research, Transcription, Genetic, Physiology, Angiogenesis, Activin Receptors, Type II, Clinical Biochemistry, Cell, ALK1, Biology, Pathophysiology, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Endothelial cell, Neoplasms, Biomarkers, Tumor, medicine, Animals, Humans, Lectins, C-Type, Original Paper, Tumor biology, Kinase, Vascular Endothelial Growth Factor Family, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer cell, Female, Cell Adhesion Molecules, Transforming growth factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41beab90000aa1b91879592446bf39c1Test
https://doi.org/10.1007/s10456-018-9642-5Test

6

Mutational and phenotypic characterization of hereditary hemorrhagic telangiectasia

المؤلفون: Karyn Megy, Willem H. Ouwehand, Loren Kell, Jonathan Stephens, Kate Downes, Abigail Shurr, Claire L. Shovlin, Ilenia Simeoni, D Patel, Maria E. Bernabeu-Herrero, Micheala A. Aldred, Zoe C. Frazer, Christopher J. Penkett, Luca Jovine, Jennifer Brimley, Isobel G. Turbin, Ernest Turro

المساهمون: Imperial College Trust, Imperial College Healthcare NHS Trust, Imperial College Healthcare NHS Trust - CLRN Funding, Imperial College Healthcare NHS Trust- BRC Funding

المصدر: Blood

مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Clinical Trials and Observations, Activin Receptors, Type II, DNA Mutational Analysis, ALK1, Biochemistry, Cohort Studies, 0302 clinical medicine, Genotype, Growth Differentiation Factor 2, 1102 Cardiorespiratory Medicine and Haematology, Smad4 Protein, Massive parallel sequencing, medicine.diagnostic_test, Endoglin, GENETIC-VARIATION, High-Throughput Nucleotide Sequencing, TGF-BETA, Hematology, Genomics, GENOTYPE, PREVALENCE, Phenotype, Medical genetics, ARTERIOVENOUS-MALFORMATIONS, Female, Telangiectasia, Hereditary Hemorrhagic, Life Sciences & Biomedicine, medicine.medical_specialty, Heterozygote, Immunology, Context (language use), Computational biology, Biology, HHT, 03 medical and health sciences, Human Phenotype Ontology, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Genetic Association Studies, Genetic testing, Retrospective Studies, Science & Technology, IDENTIFICATION, 1103 Clinical Sciences, Cell Biology, Sequence Analysis, DNA, 030104 developmental biology, Mutation, 1114 Paediatrics and Reproductive Medicine, JUVENILE POLYPOSIS, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67c88ac838f58210b09668375add670Test
https://europepmc.org/articles/PMC7717479Test/

7

Endoplasmic Reticulum Associated Protein Degradation (ERAD) in the Pathology of Diseases Related to TGFβ Signaling Pathway: Future Therapeutic Perspectives

المؤلفون: Nesrin Gariballa, Bassam R. Ali

المصدر: Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f39e553bf27151d487a3897133f698Test
https://www.frontiersin.org/articles/10.3389/fmolb.2020.575608/fullTest

8

Bioreactor-Controlled Physoxia Regulates TGF-β Signaling to Alter Extracellular Matrix Synthesis by Human Chondrocytes

المؤلفون: Sven Nebelung, Thomas Pufe, Seval Gunes, Holger Jahr, Annika-Ricarda Kuhn

المصدر: International Journal of Molecular Sciences, 20(7):1715. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1715 (2019)
International Journal of Molecular Sciences
International journal of molecular sciences 20(7), 1715 (2019). doi:10.3390/ijms20071715 special issue: "Special Issue "Osteoarthritis and Cartilage Regeneration: Focus on Pathophysiology and Molecular Mechanisms" / Special Issue Editors: Prof. Dr. Susanne Grässel, Guest Editor; PD Dr. Attila Aszodi, Guest Editor"
Volume 20
Issue 7

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, 0301 basic medicine, physiological oxygen, medicine.medical_treatment, mesenchymal stem-cells, Smad2 Protein, ALK1, hypoxia-inducible factors, TGF- receptors, ALK5, Extracellular matrix, lcsh:Chemistry, Bioreactors, 0302 clinical medicine, Transforming Growth Factor beta, Gene expression, Protein Isoforms, Aggrecans, chondrogenic differentiation, lcsh:QH301-705.5, Spectroscopy, TGF-β superfamily, TGF-β receptors, type I, type II, type III, GENE-EXPRESSION, endoglin, HUMAN ARTICULAR CHONDROCYTES, Chemistry, type II, SOX9 Transcription Factor, General Medicine, progenitor cells, Extracellular Matrix, Computer Science Applications, Cell biology, Oxygen tension, Hypoxia-inducible factors, 030220 oncology & carcinogenesis, Signal Transduction, Smad5 Protein, TGF- superfamily, GROWTH-FACTOR, type III, BONE-MARROW, type I, in-vitro, Article, Catalysis, Hypoxia-Inducible Factor-Proline Dioxygenases, Smad1 Protein, Sp1, Inorganic Chemistry, Transforming Growth Factor beta2, ALK1, ALK5, 03 medical and health sciences, Chondrocytes, medicine, Humans, Smad3 Protein, Physical and Theoretical Chemistry, physoxia, Collagen Type II, Molecular Biology, Transcription factor, betaglycan, hypertrophic differentiation, Growth factor, Organic Chemistry, Mesenchymal stem cell, Endoglin, Collagen Type III, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Smad8 Protein, Sp1/3, chondrocytic marker expression

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e2ddd41f80f96729e5e67022b4369eTest
https://cris.maastrichtuniversity.nl/en/publications/8a44354e-d752-469e-a65b-452327fb8fdaTest

9

The TGFβ Family in Human Placental Development at the Fetal-Maternal Interface

المؤلفون: Marta Sorokina Alexdóttir, Susana M. Chuva de Sousa Lopes, Gudrun Valdimarsdottir

المساهمون: Lífvísindasetur (HÍ), Biomedical Center (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland

المصدر: BIOMOLECULES
Biomolecules, 10(3). MDPI
Biomolecules
Biomolecules, Vol 10, Iss 3, p 453 (2020)

مصطلحات موضوعية: 0301 basic medicine, Human placental development, lcsh:QR1-502, Review, TGF beta family, Human trophoblast stem cells, Biochemistry, lcsh:Microbiology, human placental development, Maternal interface, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Transforming Growth Factor beta, Medicine and Health Sciences, beta family, epithelial-to-mesenchymal transition of trophoblasts, organoids, BONE MORPHOGENETIC PROTEIN, education.field_of_study, TROPHOBLAST CELL INVASION, mesenchymal-to-endothelial transition of extravillous trophoblasts, Cell Differentiation, TGF, Trophoblasts, Cell biology, Organoids, medicine.anatomical_structure, 030220 oncology & carcinogenesis, embryonic structures, Female, Stem cell, Population, Fylgja, Biology, Fósturfræði, Fetal, preeclampsia, 03 medical and health sciences, TGFβ family, human trophoblast stem cells, medicine, Humans, education, HUMAN ENDOMETRIUM, Molecular Biology, Fetus, GROWTH-FACTOR-BETA, INHIBIN-A, fetal-maternal interface, fetal–maternal interface, Trophoblast, Placentation, 3-DIMENSIONAL CULTURE, IN-VITRO, Epithelial-to-mesenchymal transition of trophoblasts, Placental disease, medicine.disease, Preeclampsia, Embryonic stem cell, ENDOTHELIAL-CELLS, Stofnfrumur, KINASE 1 ALK1, 030104 developmental biology, ACTIVIN-A, Transforming growth factor

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09868a7c0445e9a2f79c1415d3de00e5Test
https://hdl.handle.net/20.500.11815/2409Test

10

A signaling crosstalk between BMP9 and HGF/c-met regulates mouse adult liver progenitor cell survival

المؤلفون: Nerea Lazcanoiturburu, Isabel Fabregat, Laura Almalé, María García-Álvaro, Peter ten Dijke, Rebeca Méndez, Aránzazu Sánchez, Annalisa Addante, C. Roncero, Blanca Herrera

المصدر: Cells, 9(3). MDPI
Dipòsit Digital de la UB
Universidad de Barcelona
Cells, Vol 9, Iss 3, p 752 (2020)
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
Cells
Volume 9
Issue 3

مصطلحات موضوعية: 0301 basic medicine, Aging, Activin Receptors, Type II, SMAD1, Smad Proteins, Apoptosis, SMAD, ALK1, p38 Mitogen-Activated Protein Kinases, chemistry.chemical_compound, Mice, 0302 clinical medicine, Growth Differentiation Factor 2, HGF, lcsh:QH301-705.5, Biología molecular, Hepatocyte Growth Factor, Stem Cells, Malalties del fetge, apoptosis, General Medicine, Proto-Oncogene Proteins c-met, Liver regeneration, 3. Good health, Cell biology, Crosstalk (biology), Liver, 030220 oncology & carcinogenesis, p38MAPK, Hepatocyte growth factor, Mothers against decapentaplegic, medicine.drug, Signal Transduction, Bioquímica, C-Met, Cell Survival, Biology, signaling crosstalk, Bone morphogenetic protein, BMP9, Article, Cell Line, 03 medical and health sciences, hepatic oval cell, medicine, Animals, Humans, Progenitor cell, Liver diseases, Apoptosi, Enzyme Activation, 030104 developmental biology, chemistry, lcsh:Biology (General)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3aef51c14ed766ce0546c4c25e2b10Test
http://hdl.handle.net/1887/3182615Test

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