المؤلفون: Nico Fischer, Tina Dahlby, Melissa Koomen, Thomas Mandrup-Poulsen, Charna Dibner, Volodymyr Petrenko, Phillip Alexander Keller Andersen, Seyed Mojtaba Ghiasi, Peter Horskjær Rose

المصدر: International Journal of Molecular Sciences
Andersen, P A K, Petrenko, V, Rose, P H, Koomen, M, Fischer, N, Ghiasi, S M, Dahlby, T, Dibner, C & Mandrup-Poulsen, T 2021, ' Proinflammatory cytokines perturb mouse and human pancreatic islet circadian rhythmicity and induce uncoordinated β-cell clock gene expression via nitric oxide, lysine deacetylases, and immunoproteasomal activity ', International Journal of Molecular Sciences, vol. 22, no. 1, 83, pp. 1-25 . https://doi.org/10.3390/ijms22010083Test
International Journal of Molecular Sciences, Vol. 22, No 1 (2020) P. 83
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 83, p 83 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, Interferon-gamma/metabolism/pharmacology, lcsh:Chemistry, Mice, 0302 clinical medicine, ARNTL Transcription Factors/genetics/metabolism, Insulin-Secreting Cells, Insulin, immuno-metabolism, lcsh:QH301-705.5, Spectroscopy, Cells, Cultured, ddc:616, Tumor, Cultured, diabetes, Chemistry, nitric oxide synthase, Diabetes, ARNTL Transcription Factors, General Medicine, Computer Science Applications, 3. Good health, Cell biology, Circadian Rhythm, CLOCK, PER2, medicine.anatomical_structure, Knockout mouse, Epigenetics, Female, Proteasome Endopeptidase Complex, Insulin/metabolism, Cells, Period (gene), Insulin-Secreting Cells/drug effects/metabolism, 030209 endocrinology & metabolism, Nitric Oxide, Catalysis, Article, Histone Deacetylases, Cell Line, Proinflammatory cytokine, Inorganic Chemistry, 03 medical and health sciences, Interferon-gamma, Reactive Oxygen Species/metabolism, Cell Line, Tumor, medicine, biochemistry, Animals, Humans, Viability assay, Physical and Theoretical Chemistry, ddc:612, Molecular Biology, epigenetics, Pancreatic islets, Nitric oxide synthase, Organic Chemistry, HDAC3, Proteasome Endopeptidase Complex/metabolism, 030104 developmental biology, HEK293 Cells, lcsh:Biology (General), lcsh:QD1-999, Nitric Oxide/metabolism, Histone Deacetylases/metabolism, chronobiology, Reactive Oxygen Species, Chronobiology, Immuno-metabolism

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f713196105e260c2898cb08ff9e574Test
http://europepmc.org/articles/PMC7795908Test

المؤلفون: Finn K. Hansen, Christophe Romier, Linda Marek, Martin Marek, Manfred Jung, Christoph G. W. Gertzen, Johanna Senger, Katharina Stenzel, Viktoria Marquardt, Marc Remke, Thomas Kurz, Alexandra Hamacher, Holger Gohlke, Matthias U. Kassack

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩

مصطلحات موضوعية: 0301 basic medicine, Histone Deacetylases/*metabolism, Antineoplastic Agents, Apoptosis, Pharmacology, Drug Screening Assays, Cisplatin/chemistry/*pharmacology, Histone Deacetylases, Cell Line, Dose-Response Relationship, Cell Proliferation/drug effects, 03 medical and health sciences, Structure-Activity Relationship, Antineoplastic Agents/chemistry/*pharmacology, Cell Line, Tumor, Drug Discovery, medicine, Urea, Structure–activity relationship, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Histone Deacetylase Inhibitors/chemical synthesis/chemistry/*pharmacology, Cell Proliferation, Cisplatin, Tumor, Dose-Response Relationship, Drug, Molecular Structure, Cell growth, Chemistry, Apoptosis/drug effects, HDAC8, Antitumor, Squamous carcinoma, Histone Deacetylase Inhibitors, Molecular Docking Simulation, 030104 developmental biology, Cell culture, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, Drug, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae45bc45d6f85c20596af1b3e2cbe58Test
https://hal.archives-ouvertes.fr/hal-03691179Test

المؤلفون: Victor Fernandes Vieira, Sandrine Cornaz, Luisa Cironi, Carlo Fusco, Paolo Provero, Giulia Fregni, Ivan Stamenkovic, Igor Letovanec, Michel Aguet, Tanja Petricevic

المصدر: Scientific Reports
Scientific reports, vol. 6, pp. 22113

مصطلحات موضوعية: 0301 basic medicine, Beta-catenin, Oncogene Proteins, Fusion, Blotting, Western, Animals, Axin Protein/genetics, Axin Protein/metabolism, Cell Line, Cell Line, Tumor, Gene Expression Profiling/methods, Histone Deacetylases/genetics, Histone Deacetylases/metabolism, Humans, Mice, Microscopy, Confocal, Oncogene Proteins, Fusion/genetics, Oncogene Proteins, Fusion/metabolism, RNA Interference, Repressor Proteins/genetics, Repressor Proteins/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Sarcoma, Synovial/genetics, Sarcoma, Synovial/metabolism, Sarcoma, Synovial/pathology, TCF Transcription Factors/genetics, TCF Transcription Factors/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism, Wnt Signaling Pathway/genetics, beta Catenin/genetics, beta Catenin/metabolism, TCF/LEF family, Histone Deacetylases, Article, Sarcoma, Synovial, 03 medical and health sciences, Axin Protein, AXIN2, Fusion, Wnt Signaling Pathway, Transcription factor, beta Catenin, Gene Expression Profiling, Repressor Proteins, TCF Transcription Factors, Transcription Factors, Multidisciplinary, Oncogene Proteins, Microscopy, Tumor, Synovial, biology, Blotting, Wnt signaling pathway, LRP6, Sarcoma, LRP5, Fusion protein, 030104 developmental biology, Confocal, biology.protein, Cancer research, Western, Co-Repressor Proteins

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60efadcc1928d9d1f484ba21cc89d788Test
https://doi.org/10.1038/srep22113Test