Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
| العنوان: | Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients |
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| المؤلفون: | Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Francis, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent, Argiles, Angel, Beige, Joachim, Brunet, Philippe, Cohen, Gerald, Deif, Omar Abou, Evenepoel, Pieter, Fliser, Danilo, Fridolin, Ivo, Gmerek, Andreas, Jankowski, Joachim, Jankowski, Vera, Masereeuw, Roos, Mischak, Harald, Ortiz, Alberto, Perna, Alessandra, Rodriguez-Portillo, Juan Mariano, Schanstra, Joost, Spasovski, Goce, Stamatialis, Dimitrios, Steppan, Sonja, Storr, Markus, Stegmayr, Bernd G., Stenvinkel, Peter, Thornalley, Paul J., Wiecek, Andrej |
| المساهمون: | Biomaterials Science and Technology, INSERM U-1088, Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire Ambroise Paré (CHU Ambroise Paré), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM), ProdInra, Migration, Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Franci, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent, Argiles, Angel, Beige, Joachim, Brunet, Philippe, Cohen, Gerald, Deif, Omar Abou, Evenepoel, Pieter, Fliser, Danilo, Fridolin, Ivo, Gmerek, Andrea, Jankowski, Joachim, Jankowski, Vera, Masereeuw, Roo, Mischak, Harald, Ortiz, Alberto, Perna, Alessandra, Rodriguez-Portillo, Juan Mariano, Schanstra, Joost, Spasovski, Goce, Stamatialis, Dimitrio, Steppan, Sonja, Storr, Marku, Stegmayr, Bernd G., Stenvinkel, Peter, Thornalley, Paul J., Wiecek, Andrej |
| المصدر: | SCIENTIFIC REPORTS Scientific reports, 9(1):4477. Nature Publishing Group Scientific Reports Scientific Reports, 9(1). NLM (Medline) Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-41101-8⟩ Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-41101-8⟩ Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports 1 (9), . (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | insuffisance rénale, 0301 basic medicine, Nephrology, Male, medicine.medical_treatment, SMOOTH-MUSCLE-CELLS, lcsh:Medicine, urologic and male genital diseases, Gastroenterology, Severity of Illness Index, 0302 clinical medicine, Medicine and Health Sciences, Medicine, lcsh:Science, POPULATION, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Multidisciplinary, PLASMA, PROLIFERATION, microarn articielle, activité sérique, Middle Aged, Prognosis, CANCER, Pathophysiology, female genital diseases and pregnancy complications, 3. Good health, European Uremic Toxin Work Group-EUTox, Female, INJURY MOLECULE-1, Adult, EXPRESSION, medicine.medical_specialty, Endpoint Determination, Population, Médecine humaine et pathologie, Down-Regulation, PREDICTS PROGRESSION, Article, End stage renal disease, 03 medical and health sciences, CIRCULATING MICRORNAS, Internal medicine, Humans, Renal replacement therapy, Renal Insufficiency, Chronic, General, education, Survival rate, Aged, business.industry, lcsh:R, Cancer, QUANTIFICATION, medicine.disease, Survival Analysis, accident cardiovasculaire, MicroRNAs, 030104 developmental biology, Case-Control Studies, néphropathie, Human health and pathology, lcsh:Q, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, Kidney disease |
| الوصف: | Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy - CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs' seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels. ispartof: Sci Rep vol:9 issue:1 pages:4477- ispartof: location:England status: Published online |
| وصف الملف: | application/pdf; Electronic; image/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3759a0914e17a1c35d4a31e002669e77Test https://biblio.ugent.be/publication/8609649Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3759a0914e17a1c35d4a31e002669e77 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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