Building a stem cell-based primate uterus
| العنوان: | Building a stem cell-based primate uterus |
|---|---|
| المؤلفون: | Christopher A. Penfold, Magdalena Schindler, Sophie Bergmann, Clara Munger, Thorsten Boroviak |
| المساهمون: | Bergmann, Sophie [0000-0001-6018-2844], Penfold, Christopher A [0000-0001-5823-4705], Boroviak, Thorsten E [0000-0001-8703-8949], Apollo - University of Cambridge Repository, Penfold, Christopher A. [0000-0001-5823-4705], Boroviak, Thorsten E. [0000-0001-8703-8949] |
| المصدر: | Communications Biology Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Primates, QH301-705.5, Uterine tissue, Placenta, Endometriosis, Uterus, 631/136/2086, Medicine (miscellaneous), Cell parts, Review Article, Biology, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Fetal Development, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Developmental biology, medicine, Animals, Humans, Embryo Implantation, Biology (General), Fetus, Tissue Engineering, Tissue Scaffolds, urogenital system, Stem Cells, review-article, Embryo, medicine.disease, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Embryogenesis, Female, Stem cell, 631/136, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery |
| الوصف: | The uterus is the organ for embryo implantation and fetal development. Most current models of the uterus are centred around capturing its function during later stages of pregnancy to increase the survival in pre-term births. However, in vitro models focusing on the uterine tissue itself would allow modelling of pathologies including endometriosis and uterine cancers, and open new avenues to investigate embryo implantation and human development. Motivated by these key questions, we discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organising cultures, or by controlled assembly through microfluidic and print-based technologies. Bergmann et al. discuss the construction of synthetic uteri to model the earliest stages of human embryogenesis and associated pathologies. They highlight the constituent components from which a synthetic uterus may be engineered, propose a modular approach to assembling synthetic uteri and discuss how these technologies can shed light on implantation failure and uterine pathologies. |
| وصف الملف: | application/pdf; text/xml |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792daaf42da3a53a69bec20610adf8ffTest https://www.repository.cam.ac.uk/handle/1810/326071Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....792daaf42da3a53a69bec20610adf8ff |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |