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1
المؤلفون: Sumit Aggarwal, Sumit Singh Verma, Subash C. Gupta, Sadhna Aggarwal
المصدر: Seminars in Cancer Biology. 68:8-20
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.medical_specialty, medicine.drug_class, Antineoplastic Agents, Breast Neoplasms, Antimetabolite, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Drug Discovery, medicine, Animals, Humans, Intensive care medicine, Triple-negative breast cancer, Aromatase inhibitor, business.industry, Drug Repositioning, Computational Biology, Cancer, medicine.disease, Discovery and development of mTOR inhibitors, Drug repositioning, 030104 developmental biology, Drug development, 030220 oncology & carcinogenesis, Female, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702f5b98f1929849198dd3eabc7e1d82Test
https://doi.org/10.1016/j.semcancer.2019.09.012Test -
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المؤلفون: Klaus Warnatz, Kohsuke Imai, Bénédicte Neven, Mette Holm, Ulrich Duffner, B Carpenter, Musa Karakukcu, Hassan Abolhassani, Robert Wynn, Neena Kapoor, Jennifer A. Kanakry, Marina Garcia-Prat, Mariacristina Menconi, Anna Mukhina, Pere Soler-Palacín, Takahiro Tomoda, Claudia Wehr, Diana K. Bayer, Eleonora Gambineri, Gulbu Uzel, Austen Worth, Arunkumar Modi, Mary Slatter, Tania Nicole Masmas, Dimana Dimitrova, Carsten Speckmann, J.J. Bleesing, Shankara Paneesha, Kanchan Rao, Sylwia Kołtan, Carmem Bonfim, Jasmeen Dara, Colin G. Steward, Winnie Ip, Emma C. Morris, Asghar Aghamohammadi, Andrew R. Gennery, Gašper Markelj, Luigi D. Notarangelo, Stephen M. Hughes, Sujal Ghosh, Tsubasa Okano, Ansgar Schulz, Arjan C. Lankester, Stephen Jolles, Ebru Yilmaz, Alexandra Laberko, Maria Elena Maccari, Stephan Ehl, Christopher C. Dvorak, Despina Moshous, Hyoung Jin Kang, Carolina Prando, Zohreh Nademi
المساهمون: Institut Català de la Salut, [Dimitrova D] Experimental Transplantation and Immunotherapy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md. [Nademi Z] Children’s Bone Marrow Transplant Unit, Great North Children’s Hospital, Newcastle upon Tyne, United Kingdom. The Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom. [Maccari ME, Ehl S] Department of Pediatric Hematology and Oncology, Center for Pediatrics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Center for Chronic Immunodeficiency, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. [Uzel G] Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. [Tomoda T] Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan. [Garcia-Prat M, Soler-Palacín P] Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر: Dimitrova, D, Nademi, Z, Maccari, M E, Ehl, S, Uzel, G, Tomoda, T, Okano, T, Imai, K, Carpenter, B, Ip, W, Rao, K, Worth, A J J, Laberko, A, Mukhina, A, Néven, B, Moshous, D, Speckmann, C, Warnatz, K, Wehr, C, Abolhassani, H, Aghamohammadi, A, Bleesing, J J, Dara, J, Dvorak, C C, Ghosh, S, Kang, H J, Markelj, G, Modi, A, Bayer, D K, Notarangelo, L D, Schulz, A, Garcia-Prat, M, Soler-Palacín, P, Karakükcü, M, Yilmaz, E, Gambineri, E, Menconi, M, Masmas, T N, Holm, M, Bonfim, C, Prando, C, Hughes, S, Jolles, S, Morris, E C, Kapoor, N, Koltan, S, Paneesha, S, Steward, C, Wynn, R, Duffner, U, Gennery, A R, Lankester, A C, Slatter, M & Kanakry, J A 2022, ' International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome ', Journal of Allergy and Clinical Immunology, vol. 149, no. 1, pp. 410-421.e7 . https://doi.org/10.1016/j.jaci.2021.04.036Test
The Journal of allergy and clinical immunology, vol 149, iss 1
Journal of Allergy and Clinical Immunology, 149(1), 410-421. MOSBY-ELSEVIER
The Journal of allergy and clinical immunology
Dimitrova, D, Nademi, Z, Maccari, M E, Ehl, S, Uzel, G, Tomoda, T, Okano, T, Imai, K, Carpenter, B, Ip, W, Rao, K, Worth, A J J, Laberko, A, Mukhina, A, Néven, B, Moshous, D, Speckmann, C, Warnatz, K, Wehr, C, Abolhassani, H, Aghamohammadi, A, Bleesing, J J, Dara, J, Dvorak, C C, Ghosh, S, Kang, H J, Markelj, G, Modi, A, Bayer, D K, Notarangelo, L D, Schulz, A, Garcia-Prat, M, Soler-Palacín, P, Karakükcü, M, Yilmaz, E, Gambineri, E, Menconi, M, Masmas, T N, Holm, M, Bonfim, C, Prando, C, Hughes, S, Jolles, S, Morris, E C, Kapoor, N, Koltan, S, Paneesha, S, Steward, C, Wynn, R, Duffner, U, Gennery, A R, Lankester, A C, Slatter, M & Kanakry, J A 2022, ' International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome ', The Journal of allergy and clinical immunology, vol. 149, no. 1, pp. 410-421.e7 . https://doi.org/10.1016/j.jaci.2021.04.036Test
Scientiaمصطلحات موضوعية: Graft Rejection, Male, 0301 basic medicine, Oncology, Allergy, lymphoproliferation, mTOR inhibitor, Kaplan-Meier Estimate, Regenerative Medicine, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, hemic and lymphatic diseases, Immunology and Allergy, Cumulative incidence, Child, Otros calificadores::/terapia [Otros calificadores], Immunodeficiency, Cancer, Primary immunodeficiency, Hematopoietic Stem Cell Transplantation, MTOR Inhibitors, Hematology, Middle Aged, Síndromes de deficiència immunitària - Tractament, enfermedades del sistema inmune::síndromes de inmunodeficiencia [ENFERMEDADES], Treatment Outcome, surgical procedures, operative, Child, Preschool, Immune System Diseases::Immunologic Deficiency Syndromes [DISEASES], Female, terapéutica::terapia biológica::tratamientos basados en células y tejidos::trasplante de células::trasplante de células madre::trasplante de células madre hematopoyéticas [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Homologous, Adult, medicine.medical_specialty, activated phosphoinositide 3-kinase delta syndrome, Adolescent, Class I Phosphatidylinositol 3-Kinases, Primary Immunodeficiency Diseases, graft failure, Immunology, serotherapy, Activated PI3K-delta syndrome, Context (language use), Article, Young Adult, 03 medical and health sciences, Rare Diseases, Internal medicine, medicine, Transplantation, Homologous, Humans, Preschool, Retrospective Studies, Aged, Transplantation, allogeneic hematopoietic cell transplantation, Cèl·lules mare hematopoètiques - Trasplantació, business.industry, diagnóstico::pronóstico::resultado del tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Retrospective cohort study, Other subheadings::/therapy [Other subheadings], Diagnosis::Prognosis::Treatment Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], medicine.disease, 030104 developmental biology, Graft-versus-host disease, allogeneic hemato-poietic cell transplantation, Avaluació de resultats (Assistència sanitària), Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], business, 030215 immunology
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff24621d0b56e0aaf43e9d30b95d29eTest
https://hdl.handle.net/1887/3277790Test -
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المؤلفون: Nicola Fusco, Antonio Ghidini, Gianluca Tomasello, Francesco Grossi, Fausto Petrelli, Andrea Botticelli, Michele Ghidini, Giulia Grizzi, Tommaso Savio, Mary Cabiddu
المصدر: Cancer Management and Research, Vol Volume 12, Pp 675-686 (2020)
Cancer Management and Researchمصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Estrogen receptor, Review, Palbociclib, lcsh:RC254-282, Aromatase inhibitors, Breast cancer, CDK 4/6 inhibitors, MTOR inhibitors, Neoadjuvant endocrine therapy, PI3K inhibitors, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Abemaciclib, Everolimus, business.industry, Cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Hormonal therapy, business, Tamoxifen, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1827d1c140e47f6f8a458a2962ff8f54Test
https://doi.org/10.2147/cmar.s202965Test -
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المؤلفون: Ana María Hurtado, Satu Mustjoki, Urpu Salmenniemi, Jani Huuhtanen, Pekka Ellonen, Rajiv K. Khajuria, Mikko Myllymäki, Matti Kankainen, Daehong Kim, Sofie Lundgren, Mikko A. I. Keränen, Giljun Park, Maija Itälä-Remes, Tzu Hua Chen-Liang, Andres Jerez, Samuli Eldfors, Laura Cardeñoso, Sari Hannula, Oscar Brück, Anna Kreutzman, Valle Gómez García de Soria, Tapio Lönnberg, Cecilia Muñoz-Calleja
المساهمون: Department of Clinical Chemistry and Hematology, Hematologian yksikkö, HUS Comprehensive Cancer Center, Department of Oncology, TRIMM - Translational Immunology Research Program, HUSLAB, University of Helsinki, Research Programs Unit, Institute for Molecular Medicine Finland, Department of Medical and Clinical Genetics, Helsinki University Hospital Area, Digital Precision Cancer Medicine (iCAN), Division of Pharmaceutical Biosciences, UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)
المصدر: Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
instnameمصطلحات موضوعية: 0301 basic medicine, Resistance to mTOR inhibitors, Somatic cell, T-Lymphocytes, medicine.medical_treatment, NF-KAPPA-B, Graft vs Host Disease, General Physics and Astronomy, Apoptosis, Hematopoietic stem cell transplantation, medicine.disease_cause, Graft-versus-host disease, mTORC2, ACTIVATION, Pathogenesis, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, lcsh:Science, Immunity, Cellular, Mutation, Multidisciplinary, TOR Serine-Threonine Kinases, CANCER, Cellular immunity, 3. Good health, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Haematological diseases, Mutations, Protein Binding, EXPRESSION, Medicina, Science, T cell, Blotting, Western, 3122 Cancers, T cells, BIOLOGY, Article, General Biochemistry, Genetics and Molecular Biology, REPERTOIRE, 03 medical and health sciences, medicine, Humans, Immunoprecipitation, STAT3 MUTATIONS, PI3K/AKT/mTOR pathway, Cell Proliferation, business.industry, STEM-CELL TRANSPLANTATION, General Chemistry, medicine.disease, HEK293 Cells, 030104 developmental biology, DISCOVERY, Alteration and activation, Cancer research, Hematopoietic stem cell transplantation (HSCT), lcsh:Q, business, CD4(+)
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80004dc6bc4cf39c734b43d69bf77021Test
https://doi.org/10.1038/s41467-020-16115-wTest -
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المؤلفون: Robert Tyler, Tariq Ismail, Andrew D Beggs, Kasun Wanigasooriya, João D. Barros-Silva, Yashashwi Sinha
المصدر: Cancers, Vol 12, Iss 1278, p 1278 (2020)
Cancersمصطلحات موضوعية: 0301 basic medicine, Cancer Research, mTOR inhibitors, Colorectal cancer, medicine.medical_treatment, Review, PI3K, lcsh:RC254-282, chemoradiotherapy, 03 medical and health sciences, Prostate cancer, glioblastoma multiforme, 0302 clinical medicine, Medicine, rectal cancer, Protein kinase B, PI3K/AKT/mTOR pathway, non-small cell lung cancer, business.industry, AKT, Cancer, medicine.disease, prostate cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Radiation therapy, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, head and neck cancer, radiosensitiser, business, Chemoradiotherapy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32a82a87a5b68a4d88140612380d9bfTest
https://www.mdpi.com/2072-6694/12/5/1278Test -
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المؤلفون: Malihe Hasanzadeh, Amir Avan, Gordon A. Ferns, Seyed Mahdi Hassanian, Afsane Bahrami, Majid Khazaei, Soodabeh Shahidsales, Mina Maftouh
المصدر: Journal of Cellular Biochemistry. 119:213-222
مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Antineoplastic Agents, Breast Neoplasms, Pharmacology, Biochemistry, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, Humans, In patient, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Everolimus, Cell growth, business.industry, TOR Serine-Threonine Kinases, Cancer, Cell Biology, medicine.disease, Discovery and development of mTOR inhibitors, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, business, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cceefbc6d1dcc5e783a4b2209a88d841Test
https://doi.org/10.1002/jcb.26136Test -
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المؤلفون: N. Leonard, Siobhan Nicholson, Sinead Cuffe, Stephen P. Finn, Kathy Gately, Ronan Ryan, Martin P. Barr, Susan Heavey, Niall McVeigh, Kenneth J. O'Byrne, Vincent Young
المصدر: Oncotarget
مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Veterinary medicine, Lung Neoplasms, DNA Mutational Analysis, Apoptosis, NSCLC, PI3K, 0302 clinical medicine, Piperidines, Carcinoma, Non-Small-Cell Lung, Clinical investigation, Antineoplastic Combined Chemotherapy Protocols, Medicine, Molecular Targeted Therapy, Sulfonamides, TOR Serine-Threonine Kinases, MEK inhibitor, High mortality, Drug Synergism, co-target, Middle Aged, MAP Kinase Kinase Kinases, Discovery and development of mTOR inhibitors, MEK, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Female, Research Paper, Signal Transduction, medicine.medical_specialty, Indazoles, Class I Phosphatidylinositol 3-Kinases, Translational research, Gene Expression Regulation, Enzymologic, lung, 03 medical and health sciences, Internal medicine, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Aged, Cell Proliferation, Dose-Response Relationship, Drug, business.industry, Cancer, medicine.disease, respiratory tract diseases, Clinical trial, 030104 developmental biology, A549 Cells, Mutation, Azetidines, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4a84adaa2966ee301712af6eea68d5Test
https://doi.org/10.18632/oncotarget.12755Test -
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المؤلفون: Gilda Cobellis, Francesca Cuomo, Lucia Altucci
المساهمون: Cuomo, Francesca, Altucci, Lucia, Cobellis, Gilda
المصدر: Cancers
Cancers, Vol 11, Iss 10, p 1465 (2019)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, autophagy, mTOR inhibitors, Cardiomyopathy, Review, lcsh:RC254-282, drugs, chloroquine, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Chloroquine, medicine, cancer, business.industry, Autophagy, apoptosis, drug, Cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, apoptosi, 030104 developmental biology, Oncology, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, business, Function (biology), Intracellular, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c31a7c7834a122970aa93010b80731aTest
https://pubmed.ncbi.nlm.nih.gov/31569540Test -
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المؤلفون: Ji Nie, Xuelei Ma, Jing Yang, Xiawei Wei, Yong Peng, Yuquan Wei
المصدر: Molecular Cancer
Molecular Cancer, Vol 18, Iss 1, Pp 1-28 (2019)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Antineoplastic Agents, Review, Biology, lcsh:RC254-282, PI3K signaling, PI3K, Target therapy, 03 medical and health sciences, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Neoplasms, medicine, Animals, Humans, Molecular Targeted Therapy, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cancer, Phosphoinositide-3 Kinase Inhibitors, Clinical Trials as Topic, TOR Serine-Threonine Kinases, Master regulator, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Discovery and development of mTOR inhibitors, Clinical trial, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Tumor progression, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, mTOR, Molecular Medicine, Proto-Oncogene Proteins c-akt, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760fbcdfb07da0c9e7201f544add6b61Test
http://europepmc.org/articles/PMC6379961Test -
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المؤلفون: Jennifer J. Wheler, Apostolia Maria Tsimberidou, Aung Naing, Vivek Subbiah, Siqing Fu, Razelle Kurzrock, Susan Kambrick, Bonnie S. Glisson, Sarina Anne Piha-Paul, Ralph Zinner, Xiaochun Liu, George R. Blumenschein, David S. Hong, Merrill S. Kies
المصدر: Oncotarget
Oncotarget, vol 7, iss 17
Liu, X; Kambrick, S; Fu, S; Naing, A; Subbiah, V; Blumenschein, GR; et al.(2016). Advanced malignancies treated with a combination of the VEGF inhibitor bevacizumab, anti-EGFR antibody cetuximab, and the mTOR inhibitor temsirolimus. ONCOTARGET, 7(17), 23227-23238. doi: 10.18632/oncotarget.7594. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3xx7q8fsTestمصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Maximum Tolerated Dose, Bevacizumab, Oncology and Carcinogenesis, Cetuximab, and over, bevacizumab, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, temsirolimus, Antineoplastic Combined Chemotherapy Protocols, 80 and over, medicine, Humans, PI3K/AKT/mTOR pathway, Aged, Aged, 80 and over, Sirolimus, Hematology, business.industry, Cancer, solid tumors, Middle Aged, Prognosis, medicine.disease, Discovery and development of mTOR inhibitors, Temsirolimus, Surgery, Survival Rate, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, business, Hypophosphatemia, Research Paper, Follow-Up Studies, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a46d89e727927f9fdb71c1ce8e76522Test
https://doi.org/10.18632/oncotarget.7594Test