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المؤلفون: Xiao-Jing Zhang, Jingjing Cai, Haomiao Li, Ze Chen, Hongliang Li, Zhibing Lu, Zhi-Gang She, Feng Zhou, Jiayi Liu
المصدر: Circulation Research. 128:1747-1765
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Physiology, Emerging risk, 030204 cardiovascular system & hematology, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Cardiac Conduction System Disease, Non-alcoholic Fatty Liver Disease, Risk Factors, Cardiac conduction defects, Internal medicine, Atrial Fibrillation, Nonalcoholic fatty liver disease, Prevalence, medicine, Humans, cardiovascular diseases, Risk factor, Metabolic disease, Inflammation, Ventricular Remodeling, business.industry, nutritional and metabolic diseases, Cardiac arrhythmia, Arrhythmias, Cardiac, Atrial fibrillation, medicine.disease, digestive system diseases, Oxidative Stress, 030104 developmental biology, Adipose Tissue, Disease Progression, cardiovascular system, Cardiology, Cardiology and Cardiovascular Medicine, business
الوصف: Cardiac arrhythmias and the resulting sudden cardiac death are significant cardiovascular complications that continue to impose a heavy burden on patients and society. An emerging body of evidence indicates that nonalcoholic fatty liver disease (NAFLD) is closely associated with the risk of cardiac arrhythmias, independent of other conventional cardiometabolic comorbidities. Although most studies focus on the relationship between NAFLD and atrial fibrillation, associations with ventricular arrhythmias and cardiac conduction defects have also been reported. Mechanistic investigations suggest that a number of NAFLD-related pathophysiological alterations may potentially elicit structural, electrical, and autonomic remodeling in the heart, contributing to arrhythmogenic substrates in the heart. NAFLD is now the most common liver and metabolic disease in the world. However, the upsurge in the prevalence of NAFLD as an emerging risk factor for cardiac arrhythmias has received little attention. In this review, we summarize the clinical evidence and putative pathophysiological mechanisms for the emerging roles of NAFLD in cardiac arrhythmias, with the purpose of highlighting the notion that NAFLD may serve as an independent risk factor and a potential driving force in the development and progression of cardiac arrhythmias.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1606e92776aea10bc6656b3d39a45082Test
https://doi.org/10.1161/circresaha.121.319059Test -
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المؤلفون: Lei Zhihao, Tao Lan, Chao Li, Lijie Ren, Wang Yang, Jingjing Cai, Shiyu Hu
المصدر: Neurological Research. 41:1-8
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, biology, business.industry, General Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Phospholipase A2, Neurology, Internal medicine, Ischemic stroke, medicine, Cardiology, biology.protein, lipids (amino acids, peptides, and proteins), Neurology (clinical), Risk factor, business, Acute ischemic stroke, 030217 neurology & neurosurgery
الوصف: Introduction: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well-known risk factor of atherosclerotic vascular diseases. Nevertheless, its role in the acute phase of ischemic stroke is sti...
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7fe21e681ce3847fc0d146b297830230Test
https://doi.org/10.1080/01616412.2018.1493850Test