Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia
| العنوان: | Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia |
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| المؤلفون: | Xiao-Jing Zhang, Jingjing Cai, Haomiao Li, Ze Chen, Hongliang Li, Zhibing Lu, Zhi-Gang She, Feng Zhou, Jiayi Liu |
| المصدر: | Circulation Research. 128:1747-1765 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Physiology, Emerging risk, 030204 cardiovascular system & hematology, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Cardiac Conduction System Disease, Non-alcoholic Fatty Liver Disease, Risk Factors, Cardiac conduction defects, Internal medicine, Atrial Fibrillation, Nonalcoholic fatty liver disease, Prevalence, medicine, Humans, cardiovascular diseases, Risk factor, Metabolic disease, Inflammation, Ventricular Remodeling, business.industry, nutritional and metabolic diseases, Cardiac arrhythmia, Arrhythmias, Cardiac, Atrial fibrillation, medicine.disease, digestive system diseases, Oxidative Stress, 030104 developmental biology, Adipose Tissue, Disease Progression, cardiovascular system, Cardiology, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Cardiac arrhythmias and the resulting sudden cardiac death are significant cardiovascular complications that continue to impose a heavy burden on patients and society. An emerging body of evidence indicates that nonalcoholic fatty liver disease (NAFLD) is closely associated with the risk of cardiac arrhythmias, independent of other conventional cardiometabolic comorbidities. Although most studies focus on the relationship between NAFLD and atrial fibrillation, associations with ventricular arrhythmias and cardiac conduction defects have also been reported. Mechanistic investigations suggest that a number of NAFLD-related pathophysiological alterations may potentially elicit structural, electrical, and autonomic remodeling in the heart, contributing to arrhythmogenic substrates in the heart. NAFLD is now the most common liver and metabolic disease in the world. However, the upsurge in the prevalence of NAFLD as an emerging risk factor for cardiac arrhythmias has received little attention. In this review, we summarize the clinical evidence and putative pathophysiological mechanisms for the emerging roles of NAFLD in cardiac arrhythmias, with the purpose of highlighting the notion that NAFLD may serve as an independent risk factor and a potential driving force in the development and progression of cardiac arrhythmias. |
| تدمد: | 1524-4571 0009-7330 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1606e92776aea10bc6656b3d39a45082Test https://doi.org/10.1161/circresaha.121.319059Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1606e92776aea10bc6656b3d39a45082 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244571 00097330 |
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