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المؤلفون: Nico Fischer, Tina Dahlby, Melissa Koomen, Thomas Mandrup-Poulsen, Charna Dibner, Volodymyr Petrenko, Phillip Alexander Keller Andersen, Seyed Mojtaba Ghiasi, Peter Horskjær Rose
المصدر: International Journal of Molecular Sciences
Andersen, P A K, Petrenko, V, Rose, P H, Koomen, M, Fischer, N, Ghiasi, S M, Dahlby, T, Dibner, C & Mandrup-Poulsen, T 2021, ' Proinflammatory cytokines perturb mouse and human pancreatic islet circadian rhythmicity and induce uncoordinated β-cell clock gene expression via nitric oxide, lysine deacetylases, and immunoproteasomal activity ', International Journal of Molecular Sciences, vol. 22, no. 1, 83, pp. 1-25 . https://doi.org/10.3390/ijms22010083Test
International Journal of Molecular Sciences, Vol. 22, No 1 (2020) P. 83
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 83, p 83 (2021)مصطلحات موضوعية: 0301 basic medicine, Male, Interferon-gamma/metabolism/pharmacology, lcsh:Chemistry, Mice, 0302 clinical medicine, ARNTL Transcription Factors/genetics/metabolism, Insulin-Secreting Cells, Insulin, immuno-metabolism, lcsh:QH301-705.5, Spectroscopy, Cells, Cultured, ddc:616, Tumor, Cultured, diabetes, Chemistry, nitric oxide synthase, Diabetes, ARNTL Transcription Factors, General Medicine, Computer Science Applications, 3. Good health, Cell biology, Circadian Rhythm, CLOCK, PER2, medicine.anatomical_structure, Knockout mouse, Epigenetics, Female, Proteasome Endopeptidase Complex, Insulin/metabolism, Cells, Period (gene), Insulin-Secreting Cells/drug effects/metabolism, 030209 endocrinology & metabolism, Nitric Oxide, Catalysis, Article, Histone Deacetylases, Cell Line, Proinflammatory cytokine, Inorganic Chemistry, 03 medical and health sciences, Interferon-gamma, Reactive Oxygen Species/metabolism, Cell Line, Tumor, medicine, biochemistry, Animals, Humans, Viability assay, Physical and Theoretical Chemistry, ddc:612, Molecular Biology, epigenetics, Pancreatic islets, Nitric oxide synthase, Organic Chemistry, HDAC3, Proteasome Endopeptidase Complex/metabolism, 030104 developmental biology, HEK293 Cells, lcsh:Biology (General), lcsh:QD1-999, Nitric Oxide/metabolism, Histone Deacetylases/metabolism, chronobiology, Reactive Oxygen Species, Chronobiology, Immuno-metabolism
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f713196105e260c2898cb08ff9e574Test
http://europepmc.org/articles/PMC7795908Test -
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المؤلفون: Raymond J. Pierce, Wolfgang Sippl, Julien Lancelot, Karin Schmidtkunz, Alokta Chakrabarti, Dina Robaa, Jelena Melesina, Tajith B. Shaik, Christophe Romier, Conrad V. Simoben, Manfred Jung, Srinivasaraghavan Kannan, Martin Marek
المساهمون: Romier, Christophe, Martin-Luther-Universität Halle Wittenberg (MLU), Albert-Ludwigs-Universität Freiburg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), This work and the authors of this article received funding from the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration under Grant Agreements 241865 (SEtTReND) and 602080 (A-ParaDDisE). Further support was received by the Deutsche Forschungsgemeinschaft (Ju-295/13-1, SI-868/13-1). MM, TBS and CR are supported by institutional funds from the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Université de Strasbourg., The authors acknowledge the support and the use of resources of the French Infrastructure for Integrated Structural Biology FRISBI ANR-10-INBS-05 and of Instruct-ERIC. We wish to thank members of the ESRF-EMBL joint structural biology groups and the SOLEIL synchrotron for the use of their beamline facilities and for help during data collection. We are grateful to Pierre Legrand (SOLEIL) for his kind assistance for data processing, Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)
المصدر: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, MESH: Helminth Proteins/metabolism, MESH: Histone Deacetylases/metabolism, MESH: Histone Deacetylases/genetics, Pharmaceutical Science, MESH: Protein Structure, Secondary, Gene Expression, Apoptosis, Crystallography, X-Ray, Hydroxamic Acids, Molecular Docking Simulation, MESH: Helminth Proteins/antagonists & inhibitors, MESH: Chelating Agents/chemical synthesis, Protein Structure, Secondary, Analytical Chemistry, 0302 clinical medicine, MESH: Structure-Activity Relationship, MESH: Hydroxamic Acids/chemical synthesis, Drug Discovery, MESH: Zinc/metabolism, MESH: Animals, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Histone Deacetylase Inhibitors/pharmacology, Chelating Agents, Anthelmintics, biology, Chemistry, MESH: Anthelmintics/pharmacology, Helminth Proteins, Schistosoma mansoni, epigenetics, crystal structure, docking, histone deacetylase (HDAC) inhibitors, schistosomiasis, virtual screening, MESH: Histone Deacetylases/chemistry, 3. Good health, MESH: Schistosoma mansoni/drug effects, MESH: Pyrrolidines/pharmacology, Zinc, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Protein Binding, MESH: Apoptosis/drug effects, MESH: Gene Expression, In silico, 030231 tropical medicine, MESH: Zinc/chemistry, Article, Histone Deacetylases, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, MESH: Molecular Docking Simulation, Structure–activity relationship, MESH: Protein Binding, Animals, MESH: Helminth Proteins/genetics, Protein Interaction Domains and Motifs, Physical and Theoretical Chemistry, MESH: Histone Deacetylase Inhibitors/chemical synthesis, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Virtual screening, MESH: Protein Interaction Domains and Motifs, Binding Sites, Organic Chemistry, MESH: Hydroxamic Acids/pharmacology, HDAC8, MESH: Schistosoma mansoni/growth & development, Epigenome, biology.organism_classification, MESH: Crystallography, X-Ray, MESH: Anthelmintics/chemical synthesis, Histone Deacetylase Inhibitors, 030104 developmental biology, MESH: Binding Sites, Docking (molecular), MESH: Chelating Agents/pharmacology, MESH: Schistosoma mansoni/enzymology, MESH: Helminth Proteins/chemistry, MESH: Schistosoma mansoni/genetics, MESH: Pyrrolidines/chemical synthesis
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994bTest
http://europepmc.org/articles/PMC6017931Test -
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المؤلفون: Tasset, Celine, Singh Yadav, Avilash, Sureshkumar, Sridevi, Singh, Rupali, van der Woude, Lennard, Nekrasov, Maxim, Tremethick, David, van Zanten, Martijn, Balasubramanian, Sureshkumar, Sub Molecular Plant Physiology, Molecular Plant Physiology
المساهمون: Sub Molecular Plant Physiology, Molecular Plant Physiology
المصدر: PLoS Genetics, Vol 14, Iss 3, p e1007280 (2018)
PLoS Genetics, 14(3). Public Library of Science
PLoS Geneticsمصطلحات موضوعية: 0301 basic medicine, 0106 biological sciences, Cancer Research, Fruit and Seed Anatomy, Arabidopsis, Histones/metabolism, Gene Expression, Plant Science, Biochemistry, 01 natural sciences, Histones, Histone methylation, Morphogenesis, Arabidopsis thaliana, Histone code, Genetics (clinical), Plant Growth and Development, Regulation of gene expression, 2. Zero hunger, Genetics, 0303 health sciences, Chromosome Biology, Plant Anatomy, Temperature, Eukaryota, food and beverages, Acetylation, Genomics, Plants, Hypocotyl, Chromatin, Nucleosomes, Cell biology, Arabidopsis Proteins/genetics, Histone, Experimental Organism Systems, Histone methyltransferase, Embryogenesis, Epigenetics, Transcriptome Analysis, Research Article, lcsh:QH426-470, Arabidopsis Thaliana, Transcription Factors/genetics, Plant Development, Brassica, SAP30, Biology, Research and Analysis Methods, Histone Deacetylases, Chromatin remodeling, 03 medical and health sciences, Model Organisms, Histone H1, Plant and Algal Models, DNA-binding proteins, Histone H2A, Nucleosome, Gene Regulation, Arabidopsis/genetics, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Biology and life sciences, Plant Embryo Anatomy, Arabidopsis Proteins, HDAC9, Organisms, Proteins, Computational Biology, Cell Biology, Genome Analysis, biology.organism_classification, lcsh:Genetics, 030104 developmental biology, Mutation, biology.protein, Histone Deacetylases/metabolism, Plant Embryogenesis, Developmental Biology, Transcription Factors, 010606 plant biology & botany
وصف الملف: image/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57a60975b88b4bf219bb7925e75a4bbTest
https://doi.org/10.1101/186916Test -
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المؤلفون: Scott W. Hiebert, Emma De Fabiani, Cinzia Magagnotti, Erika Fiorino, Donatella Caruso, Béatrice Desvergne, Annapaola Andolfo, Maurizio Crestani, Rui Silva, Gaia Cermenati, Nico Mitro, Federica Gilardi, Raffaella Longo, Alessandra Ferrari
المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications, vol. 8, no. 1, pp. 93مصطلحات موضوعية: Male, 0301 basic medicine, Adipose Tissue, White, Science, General Physics and Astronomy, Adipose tissue, Adipocytes/physiology, Adipose Tissue, Brown/physiology, Adipose Tissue, White/physiology, Animals, Cell Line, Diet, High-Fat, Gene Expression Regulation/physiology, Gene Silencing, Histone Deacetylases/genetics, Histone Deacetylases/metabolism, Lipid Metabolism, Mice, Mice, Knockout, White adipose tissue, Biology, Histone Deacetylases, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Adipose Tissue, Brown, Adipocytes, PPARA Gene, Fatty acid synthesis, Multidisciplinary, Fatty acid metabolism, Futile cycle, nutritional and metabolic diseases, food and beverages, Lipid metabolism, General Chemistry, HDAC3, 030104 developmental biology, Gene Expression Regulation, chemistry, Biochemistry, lipids (amino acids, peptides, and proteins), hormones, hormone substitutes, and hormone antagonists
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c512383fec48820206bfc3269b78fc0bTest
https://doi.org/10.1038/s41467-017-00182-7Test -
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المؤلفون: Judit Ovádi, Claudia A. Simões-Pires, Attila Lehotzky, Alessandra Nurisso, Philippe Bertrand, Muriel Cuendet, Nadine Martinet, Samuel Bouchet, Vincent Zwick, Christophe Blanquart
المساهمون: School of Pharmaceutical Sciences, Université de Lausanne (UNIL)-University of Geneva [Switzerland], Réseau épigénétique, Cancéropôle Grand-Ouest, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institute of Enzymology [Budapest], Research Centre for Natural Sciences, Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Authors thank the Centre National de la Recherche Scientifique– France, University of Poitiers, Region Poitou-Charentes (S.B. financial support), the Ligue Contre le Cancer: Committees of Vendée, et Charente-Maritime – France, ARSMeso44 – France, COST Actions CM1406 and CM1106 – Belgium and Hungarian OTKA Founds K-101039 and K-112144 for financial support. A.N. thanks the Excellence programme of the University of Geneva –Switzerland for financial support., Bernardo, Elizabeth, Université de Lausanne = University of Lausanne (UNIL)-Université de Genève = University of Geneva (UNIGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS)
المصدر: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Bioorganic and Medicinal Chemistry Letters, 2016, ⟨10.1016/j.bmcl.2015.11.011⟩
Bioorganic & Medicinal Chemistry Letters, Vol. 26, No 1 (2016) pp. 154-159مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Intrinsic activity, Formic Acid Esters, Stereochemistry, Clinical Biochemistry, Convergent synthesis, Pharmaceutical Science, [SDV.CAN]Life Sciences [q-bio]/Cancer, Alkenes, Hydroxamic Acids, Metathesis, Biochemistry, Histone Deacetylases, Catalysis, Dose-Response Relationship, Formic Acid Esters/chemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, [SDV.CAN] Life Sciences [q-bio]/Cancer, Models, Drug Discovery, Humans, Structure–activity relationship, Benzamides/chemistry, Benzamide, Molecular Biology, ddc:615, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, Molecular, Alkenes/chemistry, 3. Good health, Histone Deacetylase Inhibitors, 030104 developmental biology, Tubulin, Histone Deacetylase Inhibitors/chemistry/pharmacology, Hydroxamic Acids/chemistry, chemistry, Benzamides, biology.protein, Molecular Medicine, Histone Deacetylases/metabolism, Drug, Selectivity
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc9fefa73c13b45a09cef22d951db0cTest
https://www.hal.inserm.fr/inserm-01299475/documentTest -
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المؤلفون: Michelandrea De Cesare, Muriel Cuendet, Sabrina Dallavalle, Vincent Zwick, Giuseppe Giannini, Alessandra Nurisso, Raffaella Cincinelli, Valentina Zuco, Loana Musso, Franco Zunino, Claudia A. Simões-Pires
المصدر: European Journal of Medicinal Chemistry, Vol. 112 (2016) pp. 99-105
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Antineoplastic Agents, Apoptosis, Drug Screening Assays, Hydroxamic Acids, Histone Deacetylases, Histone H4, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Neoplasms, Drug Discovery, Structure–activity relationship, Humans, Biphenyl Compounds/chemistry/pharmacology, Pharmacology, ddc:615, Neoplasms/drug therapy/metabolism, biology, Colonic Neoplasms/drug therapy/metabolism, Apoptosis/drug effects, Organic Chemistry, Biphenyl Compounds, Active site, Antitumor, General Medicine, HCT116 Cells, In vitro, Hydroxamic Acids/chemistry/pharmacology, Biphenyl compound, Histone Deacetylase Inhibitors, Molecular Docking Simulation, 030104 developmental biology, Histone Deacetylase Inhibitors/chemistry/pharmacology, chemistry, Biochemistry, Acetylation, Colonic Neoplasms, biology.protein, Histone Deacetylases/metabolism, Antineoplastic Agents/chemistry/pharmacology, Drug Screening Assays, Antitumor, Derivative (chemistry)
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c41240a5dcd709036f451727b80a3b2Test
https://pubmed.ncbi.nlm.nih.gov/26890116Test