Genotype scores in energy and iron-metabolising genes are higher in elite endurance athletes than in nonathlete controls
| العنوان: | Genotype scores in energy and iron-metabolising genes are higher in elite endurance athletes than in nonathlete controls |
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| المؤلفون: | Diana Monge Martín, David Varillas Delgado, Juan Del Coso, Juan José Tellería Orriols |
| المصدر: | DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria Universidad Francisco de Vitoria |
| بيانات النشر: | Canadian Science Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Multifactorial Inheritance, Adolescent, Genotype, Physiology, Iron, Endocrinology, Diabetes and Metabolism, AMP Deaminase, Genetic profile, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Humans, Hemochromatosis Protein, Gene, Polymorphism, Genetic, Nutrition and Dietetics, biology, Athletes, 030229 sport sciences, General Medicine, biology.organism_classification, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, 030104 developmental biology, Spain, Case-Control Studies, Physical Endurance |
| الوصف: | Information about the association of energy and iron-metabolising genes with endurance performance is scarce. The objective of this investigation was to compare the frequencies of polymorphic variations of genes involved in energy generation and iron metabolism in elite endurance athletes versus nonathlete controls. Genotype frequencies in 123 male elite endurance athletes (75 professional road cyclists and 48 elite endurance runners) and 122 male nonathlete participants were compared by assessing 4 genetic polymorphisms: AMPD1 c.34C/T (rs17602729), PPARGC1A c.1444G/A (rs8192678) HFEH63D c.187C/G (rs1799945) and HFEC282Y c.845G/A (rs1800562). A weighted genotype score (w-TGS; from 0 to 100 arbitrary units (a.u.)) was calculated by assigning a corresponding weight to each polymorphism. In the nonathlete population, the mean w-TGS value was lower (39.962 ± 14.654 a.u.) than in the group of elite endurance athletes (53.344 ± 17.053 a.u). The binary logistic regression analysis showed that participants with a w-TGS > 38.975 a.u had an odds ratio of 1.481 (95% confidence interval: 1.244–1.762; p < 0.001) for achieving elite athlete status. The genotypic distribution of polymorphic variations involved in energy generation and iron metabolism was different in elite endurance athletes vs. controls. Thus, an optimal genetic profile in these genes might contribute to physical endurance in athlete status. Novelty Genetic profile in energy generation and iron-metabolising genes in elite endurance athletes is different than that of nonathletes. There is an implication of an “optimal” genetic profile in the selected genes favouring endurance sporting performance. |
| تدمد: | 1715-5320 1715-5312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1252c91cfe995f2a921b2850e8161eTest https://doi.org/10.1139/apnm-2020-0174Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be1252c91cfe995f2a921b2850e8161e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17155320 17155312 |
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