نتائج البحث

1

TRIM21 drives intervertebral disc degeneration induced by oxidative stress via mediating HIF-1α degradation

المؤلفون: Changwei Li, Jiancheng Zheng, Leilei Chang, Xingkai Zhang, Lianfu Deng, Xiaogang Bao

المصدر: Biochemical and Biophysical Research Communications. 555:46-53

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Nucleus Pulposus, Adolescent, Biophysics, Intervertebral Disc Degeneration, Degeneration (medical), Oxidative phosphorylation, medicine.disease_cause, Biochemistry, Rats, Sprague-Dawley, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Downregulation and upregulation, medicine, Animals, Humans, Molecular Biology, Cells, Cultured, Aged, biology, Chemistry, Intervertebral disc, Hydrogen Peroxide, Cell Biology, Middle Aged, Hypoxia-Inducible Factor 1, alpha Subunit, Ubiquitin ligase, Cell biology, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Ribonucleoproteins, 030220 oncology & carcinogenesis, Disc degeneration, biology.protein, Female, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f9723c47a8babbaba448cb61e293abTest
https://doi.org/10.1016/j.bbrc.2021.03.088Test

2

Chitinase 3‐like‐1, Tolloid‐like protein 1, and intergenic gene polymorphisms are predictors for hepatocellular carcinoma development after hepatitis C virus eradication by direct‐acting antivirals

المؤلفون: Sameh H. Soror, Nadia O. M. Mangoud, Mohamed El Kassas, Sahar A. Ali

المصدر: IUBMB Life. 73:474-482

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, Tolloid-Like Metalloproteinases, Hepatitis C virus, Clinical Biochemistry, Locus (genetics), Hepacivirus, medicine.disease_cause, Antiviral Agents, Polymorphism, Single Nucleotide, Biochemistry, CHI3L1, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genotype, Genetics, medicine, Humans, Chitinase-3-Like Protein 1, Allele, neoplasms, Molecular Biology, Genotyping, business.industry, Liver Neoplasms, Cell Biology, TLL1, Middle Aged, medicine.disease, Hepatitis C, digestive system diseases, 030104 developmental biology, Case-Control Studies, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44859004676d9a829af246215b21ca44Test
https://doi.org/10.1002/iub.2444Test

3

Serum HBV pregenomic RNA exhibited opposite associations with NKdim and NKbright cell immunity in treatment-naïve chronic hepatitis B patients

المؤلفون: Yurong Gu, Xiaoyan Li, Chunhong Liao, Yanhua Bi, Zexuan Huang, Youming Chen, Yuehua Huang

المصدر: Bioscience Reports

مصطلحات موضوعية: Male, 0301 basic medicine, Immunology & Inflammation, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Lymphocyte Activation, Virus Replication, medicine.disease_cause, Biochemistry, 0302 clinical medicine, Prostaglandin E2, Research Articles, Immunity, Cellular, medicine.diagnostic_test, Pregenomic rna, Viral Load, Killer Cells, Natural, Cytokine, hepatitis B virus (HBV), Host-Pathogen Interactions, Cytokines, RNA, Viral, Biomarker (medicine), Female, medicine.drug, Adult, Hepatitis B virus, Biophysics, pregenomic RNA (pgRNA), Biology, Dinoprostone, Flow cytometry, Young Adult, 03 medical and health sciences, Hepatitis B, Chronic, Cell immunity, Immunity, Virology, medicine, Humans, Molecular Biology, Natural Cytotoxicity Triggering Receptor 2, Natural Cytotoxicity Triggering Receptor 1, Cell Biology, natural killer (NK) cells, digestive system diseases, 030104 developmental biology, Immunology, RNA, Biomarkers, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3944ac60ca44f87c1c635b24dd78a48Test
https://doi.org/10.1042/bsr20210600Test

4

S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer

المؤلفون: Hua Shen, Ralph Zinner, Jun He, Vikas Bhardwaj, Bing-Hua Jiang, Zi-Xuan Wang, Stephen C. Peiper, Xiang Li, Meng Wang, Gao-Chan Wang, Xin Ge, Zhumei Shi, Andrew E. Aplin

المصدر: Oncogene

مصطلحات موضوعية: PF-4708671, Adult, Male, 0301 basic medicine, Cancer Research, Lung Neoplasms, EGFR-TKI resistance, P70-S6 Kinase 1, Biology, medicine.disease_cause, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, MDM2, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Genetics, medicine, Animals, Humans, Lung cancer, Protein Kinase Inhibitors, Molecular Biology, Mutation, Effector, Ribosomal Protein S6 Kinases, 70-kDa, Cancer, Proto-Oncogene Proteins c-mdm2, S6K1, Prognosis, medicine.disease, Up-Regulation, respiratory tract diseases, Blockade, ErbB Receptors, Cell Transformation, Neoplastic, 030104 developmental biology, Non-small Cell lung cancer, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Mdm2, Signal transduction, Osimertinib, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5355f9ce2bb140ac9f80bc2e31d80dTest
https://doi.org/10.1038/s41388-020-01497-4Test

5

Protein-engineered molecules carrying GAD65 epitopes and targeting CD35 selectively down-modulate disease-associated human B lymphocytes

المؤلفون: Nikolina Mihaylova, Irini Doytchinova, Gabriela Valentinova Boneva, Andrey Tchorbanov, Iliyan Manoylov

المصدر: Clin Exp Immunol

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, endocrine system diseases, medicine.drug_class, Recombinant Fusion Proteins, Immunology, Receptors, Antigen, B-Cell, Protein Engineering, Monoclonal antibody, medicine.disease_cause, Peripheral blood mononuclear cell, Epitope, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Complement Receptor Type 1, Antigen, medicine, Humans, Immunology and Allergy, Autoantibodies, biology, Glutamate Decarboxylase, Chemistry, Autoantibody, Antibodies, Monoclonal, nutritional and metabolic diseases, Original Articles, Molecular biology, Diabetes Mellitus, Type 1, 030104 developmental biology, Receptors, Complement 3b, biology.protein, Epitopes, B-Lymphocyte, Female, Antibody, Peptides, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46223e192d21ba027cf8aab346543e11Test
https://doi.org/10.1111/cei.13305Test

6

Distinct Phenotypes of Islet Antigen-Specific CD4+ T Cells Among the 3 Subtypes of Type 1 Diabetes

المؤلفون: Chiharu Tsutsumi, Masayuki Shimoda, Kunimasa Yagi, Maya Matsushita, Kohjiro Ueki, Nobuyuki Takahashi, Kazuyuki Tobe, Akihisa Imagawa, Toshiaki Hanafusa, Daisuke Chujo, Fumitaka Haseda, Hiroshi Kajio, Akitsu Kawabe

المصدر: The Journal of Clinical Endocrinology & Metabolism. 105:3141-3151

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, medicine.disease_cause, Autoantigens, Severity of Illness Index, Biochemistry, Autoimmunity, 0302 clinical medicine, Endocrinology, Insulin, Age of Onset, HLA-DR Serological Subtypes, Immunoassay, Immunity, Cellular, geography.geographical_feature_category, Glutamate Decarboxylase, Middle Aged, Islet, Up-Regulation, Cytokine, Disease Progression, Female, Adult, Preproinsulin, medicine.medical_specialty, Adolescent, 030209 endocrinology & metabolism, Biology, Peripheral blood mononuclear cell, Islets of Langerhans, Young Adult, 03 medical and health sciences, Immune system, Antigen, Internal medicine, medicine, Humans, Protein Precursors, Aged, geography, Interleukin-6, Biochemistry (medical), Molecular biology, Chemokine CXCL10, Diabetes Mellitus, Type 1, 030104 developmental biology, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2261597566629bb040ba1e4c267461dTest
https://doi.org/10.1210/clinem/dgaa447Test

7

Hepatitis B virus X protein (HBx) promotes ST2 expression by GATA2 in liver cells

المؤلفون: Nanhong Tang, Siyan Chen, Luxi Wu, Xiaoqian Wang, Lirong Peng

المصدر: Molecular Immunology. 123:32-39

مصطلحات موضوعية: Adult, Liver Cirrhosis, Male, 0301 basic medicine, Hepatitis B virus, Carcinoma, Hepatocellular, Immunology, medicine.disease_cause, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Immune system, Downregulation and upregulation, Transcription (biology), medicine, Humans, Viral Regulatory and Accessory Proteins, Molecular Biology, Cells, Cultured, Chemistry, Liver Neoplasms, GATA2, Middle Aged, Interleukin-33, medicine.disease, Interleukin-1 Receptor-Like 1 Protein, Molecular biology, digestive system diseases, Up-Regulation, GATA2 Transcription Factor, Gene Expression Regulation, Neoplastic, HBx, 030104 developmental biology, medicine.anatomical_structure, Liver, Case-Control Studies, Hepatocyte, Disease Progression, Trans-Activators, Female, Liver cancer, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f774c1f7b9ab03fd440ec4fd0d69dc11Test
https://doi.org/10.1016/j.molimm.2020.04.024Test

8

Crosstalk between MEIS1 and markers of different cell signaling pathways in esophageal squamous cell carcinoma

المؤلفون: Reihaneh Alsadat Mahmoudian, Mohammad Mahdi Forghanifard

المصدر: Molecular Biology Reports. 47:3439-3448

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cell signaling, Esophageal Neoplasms, Carcinogenesis, Notch signaling pathway, Cell Cycle Proteins, Biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, SALL4, Basic Helix-Loop-Helix Transcription Factors, Biomarkers, Tumor, Genetics, medicine, Humans, Myeloid Ecotropic Viral Integration Site 1 Protein, Molecular Biology, Transcription factor, Aged, Gene Expression Profiling, Genes, Homeobox, General Medicine, Middle Aged, Reverse transcription polymerase chain reaction, Gene expression profiling, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Female, Esophageal Squamous Cell Carcinoma, Signal Transduction, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bb65987ca25030613468f5aa359dc6Test
https://doi.org/10.1007/s11033-020-05423-5Test

9

Long noncoding RNA MALAT1 contributes to pregnancy‐induced hypertension development by enhancing oxidative stress and inflammation through the regulation of the miR‐150‐5p/ET‐1 axis

المؤلفون: Qian Zhang, Xin Zhao, Huidong Zhao, Minghui Ou, Guoxin Ji

المصدر: The FASEB Journal. 34:6070-6085

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Interleukin-1beta, Apoptosis, Inflammation, medicine.disease_cause, Biochemistry, Proinflammatory cytokine, Pathogenesis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Pregnancy, Internal medicine, Genetics, medicine, Animals, Humans, Gene silencing, Rats, Wistar, Molecular Biology, Cell Proliferation, MALAT1, Endothelin-1, business.industry, NF-kappa B, Hypertension, Pregnancy-Induced, Endothelin 1, Rats, MicroRNAs, Oxidative Stress, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Female, RNA, Long Noncoding, medicine.symptom, business, 030217 neurology & neurosurgery, Oxidative stress, Signal Transduction, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516faa511f402468d86808dd5af39159Test
https://doi.org/10.1096/fj.201902280rTest

10

C1orf35 contributes to tumorigenesis by activating c-MYC transcription in multiple myeloma

المؤلفون: Xiu-Fen Bu, Jia-Ming Zhang, Wei-Xin Hu, Jiang Li, Saiqun Luo, De-Hui Xiong, Yali Wang, Guangdi Li, Jingping Hu

المصدر: Oncogene. 39:3354-3366

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622aec8aa55228d0031285b504b6ea82Test
https://doi.org/10.1038/s41388-020-1222-7Test

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