Competing Risk Analyses of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma
| العنوان: | Competing Risk Analyses of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma |
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| المؤلفون: | Dongjun Dai, Zhuo Wang, Xian Wang, Rongkai Shi, Hongchuan Jin, Yiming Zhong, Vivian Y. Shin |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Oncology, medicine.medical_specialty, lcsh:Medicine, Breast Neoplasms, Competing risks, Risk Assessment, Article, Young Adult, 03 medical and health sciences, Age Distribution, Breast cancer, 0302 clinical medicine, Infiltrating ductal carcinoma, Internal medicine, Epidemiology, Humans, Medicine, Medullary carcinoma of the breast, skin and connective tissue diseases, lcsh:Science, Aged, Multidisciplinary, business.industry, Carcinoma, Ductal, Breast, lcsh:R, Hazard ratio, Middle Aged, Models, Theoretical, Nomogram, Prognosis, medicine.disease, Tumor Burden, Nomograms, 030104 developmental biology, Socioeconomic Factors, Risk factors, Medullary carcinoma, Carcinoma, Medullary, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, lcsh:Q, business, SEER Program |
| الوصف: | The aim of current study was to use competing risk model to assess whether medullary carcinoma of the breast (MCB) has a better prognosis than invasive ductal carcinomas of breast cancer (IDC), and to build a competing risk nomogram for predicting the risk of death of MCB. We involved 3,580 MCB patients and 319,566 IDC patients from Surveillance, Epidemiology, and End Results (SEER) database. IDC was found to have a worse BCSS than MCB (Hazard ratio (HR) > 1, p 1, p 0.05). After a penalized variable selection process, the SH model-based nomogram showed moderate accuracy of prediction by internal validation of discrimination and calibration with 1,000 bootstraps. In summary, MCB patients had a better prognosis than IDC patients. Interestingly, unmarried status in addition to expected risk factors such as larger tumor size and increasing number of positive lymph nodes were found to worsen the BCSS of MCB. We also established a competing risk nomogram as an easy-to-use tool for prognostic estimation of MCB patients. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0f27215c86e76f76381ede1fb8dbc1Test https://doi.org/10.1038/s41598-019-57168-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9c0f27215c86e76f76381ede1fb8dbc1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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