نتائج البحث

1

Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity

المؤلفون: Martin Haupt-Jorgensen, Karsten Buschard, Flemming Pociot, Kristina Pedersen, Knut Dahl-Jørgensen, Ivan C. Gerling, Simranjeet Kaur, Lars Krogvold

المصدر: Diabetologia
Pedersen, K, Haupt-Jorgensen, M, Krogvold, L, Kaur, S, Gerling, I C, Pociot, F, Dahl-Jørgensen, K & Buschard, K 2021, ' Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes : potential contribution to dysregulation of innate antiviral immunity ', Diabetologia, vol. 64, no. 8, pp. 1805-1815 . https://doi.org/10.1007/s00125-021-05469-5Test

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Ribonuclease L, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Disease, Type 2 diabetes, Biology, Interferon α, RNase L, Type 1 interferon, Antiviral Agents, Polymorphism, Single Nucleotide, Article, Virus, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Immune system, Internal Medicine, Genetic predisposition, medicine, Humans, Genetic Predisposition to Disease, RNA, Messenger, Gene, Type 1 diabetes, Oligoribonucleotides, Adenine Nucleotides, RNA-Binding Proteins, medicine.disease, Immunity, Innate, Toll-like receptor 7, Diabetes Mellitus, Type 1, 030104 developmental biology, Gene Expression Regulation, Virus Diseases, Immunology, 2′-5′A pathway, 2′-5′ Oligoadenylate synthetase, Female, Genome-Wide Association Study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7c11e2de9bab5e6655271157f4e1c3Test
https://doi.org/10.1007/s00125-021-05469-5Test

2

Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes

المؤلفون: Carmella Evans-Molina, Clive Wasserfall, Megan T Legge, Eleni Beli, Craig A. Beam, Ryan Silk, Kieran M. Mcgrail, Linda A. DiMeglio, Mark A. Atkinson, Stephanie Woerner, Maria B. Grant

المصدر: Diabetologia
Beam, C A, Beli, E, Wasserfall, C H, Woerner, S E, Legge, M T, Evans-Molina, C, McGrail, K M, Silk, R, Grant, M B, Atkinson, M A & DiMeglio, L A 2021, ' Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes ', Diabetologia . https://doi.org/10.1007/s00125-021-05468-6Test

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Male, type 1 diabetes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Circadian clock, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Mice, 0302 clinical medicine, Cytotoxic T cell, education.field_of_study, B-Lymphocytes, Immune cells, Flow Cytometry, Circadian Rhythm, Cytokine, Type 1 diabetes, Female, Adult, Adolescent, Period (gene), Population, Biology, Chronobiology Disorders, circadian ryhtms, Article, 03 medical and health sciences, Clinical, Young Adult, Immune system, SDG 3 - Good Health and Well-being, Circadian Clocks, Internal Medicine, medicine, Animals, Humans, Circadian rhythms, Circadian rhythm, Lymphocyte Count, education, Interleukin-6, Dendritic Cells, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Diabetes Mellitus, Type 1, Immune System, Immunology, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5304384a2a7eb86434e13bd1acc63ddbTest
http://europepmc.org/articles/PMC8245361Test

3

Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1

المؤلفون: Peter J. Oefner, Damian R. Plichta, Anders Ø. Petersen, Daniel C. Chung, Wolfram Gronwald, Ramnik J. Xavier, Annamari Ranki, Hera Vlamakis, Martta Jokinen, Gerhard Liebisch, Katja Dettmer

المصدر: J Allergy Clin Immunol
Petersen, A, Jokinen, M, Plichta, D R, Liebisch, G, Gronwald, W, Dettmer, K, Oefner, P J, Vlamakis, H, Chung, D C, Ranki, A & Xavier, R J 2021, ' Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1 ', Journal of Allergy and Clinical Immunology, vol. 148, no. 3, pp. 876-888 . https://doi.org/10.1016/j.jaci.2021.03.025Test

مصطلحات موضوعية: Male, 0301 basic medicine, Lactobacillus rhamnosus GG, Autoimmunity, medicine.disease_cause, GABA, Autoantibody, 0302 clinical medicine, Immunology and Allergy, Child, Polyendocrinopathies, Autoimmune, Irritable bowel syndrome, biology, Lacticaseibacillus rhamnosus, Tryptophan, Middle Aged, 3. Good health, Actinobacteria, Diarrhea, Chemokine, Child, Preschool, Cytokines, Female, medicine.symptom, Adult, Adolescent, Immunology, Article, Young Adult, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Lactobacillus rhamnosus, medicine, APS-1, Humans, Microbiome, Cytokine, Aged, Autoantibodies, Autoimmune disease, Bacteroidetes, business.industry, Probiotics, medicine.disease, biology.organism_classification, Gastrointestinal Microbiome, 030104 developmental biology, Autoimmune polyendocrine syndrome type 1, Mutation, business, 030217 neurology & neurosurgery, APECED, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808656f1200240d39f165329158bc32eTest
https://doi.org/10.1016/j.jaci.2021.03.025Test

4

Beta cell-specific CD8+ T cells maintain stem-cell memory-associated epigenetic programs during type 1 diabetes

المصدر: Nature immunology
Nature immunology, vol 21, iss 5
Nature Immunology

مصطلحات موضوعية: 0301 basic medicine, Male, Cell Plasticity, CD8-Positive T-Lymphocytes, Regenerative Medicine, Autoantigens, Epigenesis, Genetic, Mice, 0302 clinical medicine, Stem Cell Research - Nonembryonic - Human, Insulin-Secreting Cells, 2.1 Biological and endogenous factors, Immunology and Allergy, Cytotoxic T cell, Aetiology, Cells, Cultured, Cultured, Diabetes, Acquired immune system, Flow Cytometry, Cell biology, medicine.anatomical_structure, Female, Stem cell, Beta cell, Single-Cell Analysis, Type 1, Adult, Pluripotent Stem Cells, Adolescent, Cells, T cell, Immunology, Biology, Autoimmune Disease, Article, 03 medical and health sciences, Young Adult, Genetic, Diabetes Mellitus, Genetics, medicine, Animals, Humans, Epigenetics, Metabolic and endocrine, DNA Methylation, Stem Cell Research, 030104 developmental biology, Diabetes Mellitus, Type 1, T cell differentiation, Immunologic Memory, CD8, Epigenesis, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c766e2ff25c8b1dacf4caad1134276Test
http://europepmc.org/articles/PMC7183435Test

5

Metabolic alterations in immune cells associate with progression to type 1 diabetes

المؤلفون: Heikki Hyöty, Santosh Lamichhane, Jorma Ilonen, Partho Sen, Jorma Toppari, Tuomas Lindeman, Matej Orešič, Esko Kemppainen, Riitta Veijola, María Asunción López-Bascón, Tuukka Rönkkö, Mikael Knip, Tuulia Hyötyläinen, Alex M. Dickens

المساهمون: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Tampere University, HUS Children and Adolescents, Children's Hospital, Research Programs Unit, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine

المصدر: Diabetologia

مصطلحات موضوعية: Male, 0301 basic medicine, PREDICTION, Endocrinology, Diabetes and Metabolism, CHILDHOOD, Autoimmunity, ACTIVATION, Transcriptome, 0302 clinical medicine, Longitudinal Studies, RISK, Aged, 80 and over, Sisätaudit - Internal medicine, Middle Aged, 3. Good health, Type 1 diabetes, Disease Progression, Female, Birth cohort, Adult, FEASIBILITY, Genotype, 030209 endocrinology & metabolism, Ceramides, Peripheral blood mononuclear cell, Article, Islets of Langerhans, Young Adult, 03 medical and health sciences, Metabolomics, Immune system, INFLAMMATION, Lipidomics, Internal Medicine, medicine, Humans, Aged, Autoantibodies, Sphingolipids, business.industry, Sphingolipid metabolism, Autoantibody, Lipid metabolism, Lipid Metabolism, medicine.disease, MICROBIOME, Diabetes Mellitus, Type 1, 030104 developmental biology, Genome-scale metabolic modelling, Peripheral blood mononuclear cells, ANTIBODIES, Immunology, Leukocytes, Mononuclear, 3111 Biomedicine, ISLET AUTOANTIBODIES, business

وصف الملف: application/pdf; fulltext; 1017–1031

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8db141e75e5dead62b6ef2f2c63a3dTest
https://doi.org/10.1007/s00125-020-05107-6Test

6

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

المصدر: Nat Immunol

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Galectin 1, Lipopolysaccharide, Mice, chemistry.chemical_compound, 0302 clinical medicine, Alarmins, Immunology and Allergy, Caspase, Aged, 80 and over, Mice, Knockout, biology, Intracellular Signaling Peptides and Proteins, Pyroptosis, Middle Aged, Up-Regulation, Cell biology, Necroptosis, Female, Inflammation Mediators, medicine.symptom, Signal transduction, Intracellular, Signal Transduction, Adult, animal structures, Immunology, Inflammation, PTPRC, Article, 03 medical and health sciences, Sepsis, otorhinolaryngologic diseases, medicine, Animals, Humans, Aged, Macrophages, Phosphate-Binding Proteins, Endotoxemia, Mice, Inbred C57BL, Disease Models, Animal, stomatognathic diseases, RAW 264.7 Cells, 030104 developmental biology, chemistry, Case-Control Studies, biology.protein, Leukocyte Common Antigens, HeLa Cells, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd368de112bdf46f79b07a7aa7e0a0dTest
https://doi.org/10.1038/s41590-020-00844-7Test

7

Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes

المؤلفون: Dawit A. Yohannes, Katri Kaukinen, Katri Lindfors, Matti Nykter, Päivi Saavalainen, Aarno Palotie, Juliana X. M. Cerqueira, Kalle Kurppa, Lotta L. E. Koskinen, Elina Kilpeläinen, Anastasia Shcherban, Pilvi Laurikka, Heini Huhtala

المساهمون: Tampere University, BioMediTech, Department of Paediatrics, Clinical Medicine, Health Sciences, Department of Internal medicine, Immunomics, Department of Medical and Clinical Genetics, University of Helsinki, Research Programme of Molecular Medicine, Research Programs Unit, TRIMM - Translational Immunology Research Program, Genomics of Neurological and Neuropsychiatric Disorders, Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, HUS Helsinki and Uusimaa Hospital District

المصدر: Journal of Human Genetics

مصطلحات موضوعية: 0301 basic medicine, Male, Malabsorption, Genome-wide association study, VARIANTS, Genome-wide association studies, Coeliac disease, 0302 clinical medicine, MULTIPLE COMMON, Child, POPULATION, Genetics (clinical), Ataxin-2, RISK, education.field_of_study, Disease genetics, 1184 Genetics, developmental biology, physiology, Middle Aged, 3. Good health, Phenotype, Child, Preschool, 030211 gastroenterology & hepatology, Female, Genetic databases, Adult, Adolescent, Genotype, Population, Genetic predisposition to disease, Locus (genetics), Single-nucleotide polymorphism, 3121 Internal medicine, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Young Adult, Dermatitis herpetiformis, LINKAGE, Genetics, medicine, Diabetes Mellitus, Humans, GENOME-WIDE ASSOCIATION, education, Adaptor Proteins, Signal Transducing, Aged, Type 1 diabetes, business.industry, Infant, medicine.disease, Celiac Disease, 030104 developmental biology, Toll-Like Receptor 7, Toll-Like Receptor 8, Immunology, 3111 Biomedicine, business, Genome-Wide Association Study