Bridging therapy or IV thrombolysis in minor stroke with large vessel occlusion
| العنوان: | Bridging therapy or IV thrombolysis in minor stroke with large vessel occlusion |
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| المؤلفون: | Gioia Mione, Pierre Seners, Isabelle Girard Buttaz, Claire Perrin, Guillaume Turc, Ruben Tamazyan, Jean-Claude Baron, Hilde Hénon, Denis Sablot, Bertrand Lapergue, Cécile Preterre, Nadia Laksiri, Ludovic Lucas, Séverine Debiais, Caroline Arquizan |
| المساهمون: | Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Hôpital Foch [Suresnes], Département de neurologie[Lille], Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Saint Jean de Perpignan, Neurologie - Centre Hospitalier de Valenciennes (CHV), Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, MINOR-STROKE collaborators : Achard S, Agius P, Alamowitch S, Arteaga C, Bennani O, Ben Hassen W, Ben Maacha M, Berthezene Y, Boulanger M, Boutet C, Bracard S, Bricout N, Brunel H, Cakmak S, Charron S, Charron V, Chassin O, Clarençon F, Chbicheb M, Consoli A, Cottier JP, Courselle-Arnoux A, Dargazanli C, Denier C, Dereeper O, Derex L, Desal H, Detante O, Duong DL, Fraticelli L, Gazzola S, Garnier P, Grigoras V, Gouttard S, Guedon A, Hattinguais J, Henri C, Klapczynski F, Lamy C, Ledure S, Leys D, Lopez D, Lun F, Lyoubi A, Malbranque A, Marcel S, Louis Mas J, Masson M, Mechtouff L, Mounier-Vehier F, Niclot P, Nighoghossian N, Obadia A, Oppenheim C, Papagiannaki C, Papassin J, Philippeau F, Pico F, Piotin M, Pires C, Rosso C, Samson Y, Serre I, Sibon I, Soize S, Smadja P, Spelle L, Suissa L, Triquenot A, Tuffal A, Vallet AE, Yger M, Zuber M., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Département de neurologie [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Martinez Rico, Clara |
| المصدر: | Annals of Neurology Annals of Neurology, Wiley, 2020, Epub ahead of print. ⟨10.1002/ana.25756⟩ Annals of Neurology, 2020, Epub ahead of print. ⟨10.1002/ana.25756⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Bridging (networking), medicine.medical_treatment, [SDV]Life Sciences [q-bio], Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Fibrinolytic Agents, Internal medicine, Occlusion, Medicine, Humans, Thrombolytic Therapy, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Aged, Retrospective Studies, Thrombectomy, Aged, 80 and over, business.industry, Endovascular Procedures, Minor stroke, Retrospective cohort study, Odds ratio, Thrombolysis, Middle Aged, Combined Modality Therapy, Confidence interval, 3. Good health, [SDV] Life Sciences [q-bio], Stroke, 030104 developmental biology, Treatment Outcome, Neurology, Cardiology, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), business, 030217 neurology & neurosurgery, Large vessel occlusion |
| الوصف: | OBJECTIVE Whether bridging therapy (intravenous thrombolysis [IVT] followed by endovascular treatment) is superior to IVT alone in minor stroke with large vessel occlusion (LVO) is unknown. METHODS Multicentric retrospective observational study including, in intention-to-treat, consecutive IVT-treated minor strokes (National Institutes of Health Stroke Scale [NIHSS] ≤ 5) with LVO, with or without additional mechanical thrombectomy. Propensity-score (inverse probability of treatment weighting) was used to reduce baseline between-groups differences. The primary outcome was excellent outcome, that is, modified Rankin score 0 to 1 at 3 months follow-up. RESULTS Overall, 598 patients were included (214 and 384 in the bridging therapy and IVT groups, respectively). Following propensity-score weighting, the distribution of baseline clinical and radiological variables was similar across the two patient groups. Compared with IVT alone, bridging therapy was not associated with excellent outcome (odds ratio [OR] = 0.96; 95% confidence interval [CI] = 0.75-1.24; p = 0.76), but was associated with symptomatic intracranial hemorrhage (OR = 3.01; 95% CI = 1.77-5.11; p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0364-5134 1531-8249 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5249e216dc17309b61f075dbb00c90b6Test https://www.hal.inserm.fr/inserm-02570598Test |
| حقوق: | EMBARGO |
| رقم الانضمام: | edsair.doi.dedup.....5249e216dc17309b61f075dbb00c90b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03645134 15318249 |
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