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المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 37

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Male, rheumatoid arthritis, 0301 basic medicine, Tcr signaling, Biopsy, medicine.medical_treatment, Endogeny, medicine.disease_cause, Transgenic, Autoimmunity, Arthritis, Rheumatoid, Mice, Immunology and Inflammation, Nur77, 0302 clinical medicine, Genes, Reporter, Synovectomy, Rheumatoid, Receptors, Nuclear Receptor Subfamily 4, Group A, Member 1, 2.1 Biological and endogenous factors, SOCS3, Aetiology, Receptor, Group A, 0303 health sciences, Multidisciplinary, Interleukin-17, Synovial Membrane, autoimmunity, Cell Differentiation, Middle Aged, Biological Sciences, Cytokine, Rheumatoid arthritis, Antigen, Female, Signal Transduction, Nuclear Receptor Subfamily 4, Adult, Member 1, Nerve growth factor IB, Green Fluorescent Proteins, Receptors, Antigen, T-Cell, T cells, Down-Regulation, Mice, Transgenic, Biology, Autoimmune Disease, Experimental, 03 medical and health sciences, Downregulation and upregulation, medicine, Animals, Humans, antigen receptor signaling, Reporter, 030304 developmental biology, Aged, 030203 arthritis & rheumatology, Cluster of differentiation, Interleukin-6, Arthritis, Inflammatory and immune system, T-cell receptor, Zymosan, medicine.disease, T-Cell, Arthritis, Experimental, 030104 developmental biology, Genes, Suppressor of Cytokine Signaling 3 Protein, Immunology, Th17 Cells, Ex vivo, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8b3b92009ae4696c750baabc52dc45Test
https://doi.org/10.1073/pnas.1904271116Test

15

CAR directs T cell adaptation to bile acids in the small intestine

المصدر: Nature

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, 0301 basic medicine, medicine.drug_class, T-Lymphocytes, medicine.medical_treatment, T cell, Receptors, Cytoplasmic and Nuclear, Article, Bile Acids and Salts, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Crohn Disease, Intestine, Small, medicine, Animals, Ileitis, ATP Binding Cassette Transporter, Subfamily B, Member 1, Receptor, Enterohepatic circulation, Constitutive Androstane Receptor, Inflammation, Multidisciplinary, Bile acid, Chemistry, medicine.disease, Small intestine, Interleukin-10, Cell biology, 030104 developmental biology, Cytokine, medicine.anatomical_structure, Gene Expression Regulation, Female, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f9859e3dc924c36f9f51ca55a06332Test
https://doi.org/10.1038/s41586-021-03421-6Test

16

Lysine 268 adjacent to transmembrane helix 5 of hamster P‐glycoprotein is the major photobinding site of iodomycin in CHO B30 cells

المؤلفون: Annette Demmer, Hubert Thole, Manfred Raida, Burkhard Tümmler

المصدر: FEBS Open Bio, Vol 11, Iss 4, Pp 1084-1092 (2021)
FEBS Open Bio

مصطلحات موضوعية: 0301 basic medicine, Edman sequencing, Protein Conformation, Lysine, Hamster, CHO Cells, anthracycline, General Biochemistry, Genetics and Molecular Biology, Iodine Radioisotopes, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, multidrug resistance, Cricetinae, P‐glycoprotein, Animals, Humans, Protein Interaction Domains and Motifs, ATP Binding Cassette Transporter, Subfamily B, Member 1, Binding site, lcsh:QH301-705.5, Research Articles, P-glycoprotein, Binding Sites, Membrane Glycoproteins, Edman degradation, biology, Photoaffinity labeling, Chemistry, Daunorubicin, drug‐binding site, Transmembrane protein, Transmembrane domain, 030104 developmental biology, Biochemistry, lcsh:Biology (General), 030220 oncology & carcinogenesis, biology.protein, ABC transporter, Peptides, Research Article, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2055486f6d55e1da7a4a56e9078189Test
https://doaj.org/article/c2b81dd83c9042d1b7692f7ae5d4f30bTest

17

CX3CR1 deficiency aggravates brain white matter injury and affects expression of the CD36/15LO/NR4A1 signal

المؤلفون: Jingbo Wang, Xiwen Zhu, Qing Tang, Yuzheng Pan, Rui Zhu, Xingxing Liu, Jintao Yu, Shanshan Ran, Wang Wenzhu, Xinjie Liu, Dandan Cui, Chunzhu Wei

المصدر: Biochemical and Biophysical Research Communications. 549:47-53

مصطلحات موضوعية: CD36 Antigens, Male, 0301 basic medicine, medicine.medical_specialty, Traumatic brain injury, CX3C Chemokine Receptor 1, Biophysics, Corpus callosum, Biochemistry, Lesion, White matter, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Brain Injuries, Traumatic, Fractional anisotropy, CX3CR1, Nuclear Receptor Subfamily 4, Group A, Member 1, medicine, Animals, Arachidonate 15-Lipoxygenase, Molecular Biology, Behavior, Animal, Microglia, business.industry, Cell Biology, medicine.disease, White Matter, Axons, nervous system diseases, Mice, Inbred C57BL, Diffusion Tensor Imaging, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, nervous system, 030220 oncology & carcinogenesis, Anisotropy, medicine.symptom, Forelimb, business, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293bd28707b7b9a9d01a4e21e4dc94eeTest
https://doi.org/10.1016/j.bbrc.2021.02.053Test

18

ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib

المؤلفون: Li, Wenlong, Sparidans, Rolf W, Martins, Margarida L F, El-Lari, Mujtaba, Lebre, Maria C, van Tellingen, Olaf, Beijnen, Jos H, Schinkel, Alfred H, Afd Pharmacoepi & Clinical Pharmacology, Afd Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Pharmacology

المصدر: Molecular Cancer Therapeutics, 20(6), 1173. American Association for Cancer Research Inc.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b4ccd9698112277aca158f068a9af6Test
https://doi.org/10.1158/1535-7163.mct-20-0705Test

19

Cystine supplementation rebalances the redox homeostasis of microenvironment in non-small cell lung cancer cells and reverses their resistance to docetaxel

المؤلفون: Zhenyao Lu, Guangji Wang, Jiye Aa, Sijia Li, Runbin Sun, Su-han Guo, Bei Cao, Yuan Xie

المصدر: Acta Pharmacol Sin

مصطلحات موضوعية: Male, 0301 basic medicine, Lung Neoplasms, Cystine, Mice, Nude, Antineoplastic Agents, Docetaxel, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, Carcinoma, Non-Small-Cell Lung, Tumor Microenvironment, Animals, Homeostasis, Humans, Pharmacology (medical), ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, Pharmacology, A549 cell, chemistry.chemical_classification, Reactive oxygen species, biology, Drug Synergism, General Medicine, Glutathione, Up-Regulation, Cell biology, Oxidative Stress, 030104 developmental biology, chemistry, A549 Cells, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Glutathione disulfide, Reactive Oxygen Species, Oxidation-Reduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11789c4a915da11a8278c0b9bed953a5Test
https://doi.org/10.1038/s41401-020-00610-3Test

20

Rev-erb in GABAergic Neurons Controls Diurnal Hepatic Insulin Sensitivity

المؤلفون: Xin Li, Younghun Han, Paul Basil, Jia Song, Wenjun Zhou, Sichong Qian, Wenbo Li, Christopher I. Amos, Xinguo Hou, Jing Wang, Li Chen, Tingting Yang, Zheng Sun, Fuqiang Liu, Pradip K. Saha, Jinbang Wang, Yong Xu, Kexin Zou, Chen Cui, Yanlin He, Guo-Lian Ding, Yingyun Gong

المصدر: Nature

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, Photoperiod, Circadian clock, Dawn phenomenon, Stimulation, Neurotransmission, Biology, Synaptic Transmission, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Internal medicine, Circadian Clocks, medicine, Animals, Humans, Circadian rhythm, GABAergic Neurons, Mice, Knockout, Multidisciplinary, Suprachiasmatic nucleus, Middle Aged, Circadian Rhythm, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Glucose, Diabetes Mellitus, Type 2, Liver, Hypothalamus, Nuclear Receptor Subfamily 1, Group D, Member 1, Female, Suprachiasmatic Nucleus, Neuron, Insulin Resistance, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c74e4449529d74fc80aba3b6a40b118Test
http://europepmc.org/articles/PMC8085086Test

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