نتائج البحث - "Kaye J. Williams"

1

Novel phase I trial design to evaluate the addition of cediranib or selumetinib to preoperative chemoradiotherapy for locally advanced rectal cancer: the DREAMtherapy trial

المؤلفون: K L Li, Gordon C Jayson, Caroline Dive, S. Underhill, J. Allen, J. Connell, F. Marti Marti, Alison Backen, Alan Jackson, V. Misra, Kaye J. Williams, Prakash Manoharan, Mark P Saunders, Hitesh Mistry, F. Ortega, Kathryn Simpson, Ian J. Stratford, Andrew G Renehan, James P B O'Connor

المصدر: European Journal of Cancer. 117:48-59

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Maximum Tolerated Dose, Colorectal cancer, medicine.medical_treatment, Locally advanced, Cohort Studies, Capecitabine, Cediranib, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Medicine, Tissue Distribution, Aged, Rectal Neoplasms, business.industry, Chemoradiotherapy, Middle Aged, Prognosis, medicine.disease, Radiation therapy, 030104 developmental biology, 030220 oncology & carcinogenesis, Cohort, Quinazolines, Selumetinib, Benzimidazoles, Female, business, Follow-Up Studies, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ac7addafca837563d72fedf9675713Test
https://doi.org/10.1016Test/j.ejca.2019.04.029

2

Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

المؤلفون: Becky A.S. Bibby, Ronnie Rodrigues Pereira, Ananya Choudhury, Kaye J. Williams, Elisabet More, Darragh G. McArt, Robert G. Bristow, Paul G. O’Reilly, N. Thiruthaneeswaran, Catharine M L West, Lingjian Yang

المصدر: Bibby, B A S, Thiruthaneeswaran, N, Yang, L, Pereira, R R, More, E, McArt, D G, O'Reilly, P, Bristow, R G, Williams, K J, Choudhury, A & West, C M L 2021, ' Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer ', BMC urology, vol. 21, no. 1, 96 . https://doi.org/10.1186/s12894-021-00856-xTest
BMC Urology
Bibby, B A S, Thiruthaneeswaran, N, Yang, L, Pereira, R R, More, E, McArt, D G, O'Reilly, P, Bristow, R G, Williams, K J, Choudhury, A & West, C M L 2021, ' Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer ', BMC Urology, vol. 21, no. 1, pp. 96 . https://doi.org/10.1186/s12894-021-00856-xTest
BMC Urology, Vol 21, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, Radiation-Sensitizing Agents, Urology, 03 medical and health sciences, Prostate cancer, chemistry.chemical_compound, 0302 clinical medicine, Menadione, DU145, SDG 3 - Good Health and Well-being, Radioresistance, Cell Line, Tumor, LNCaP, Medicine, Humans, Clonogenic assay, Hypoxia, Manchester Cancer Research Centre, business.industry, United States Food and Drug Administration, ResearchInstitutes_Networks_Beacons/mcrc, Drug Repositioning, Prostatic Neoplasms, General Medicine, Hypoxia (medical), medicine.disease, Gemcitabine, Diseases of the genitourinary system. Urology, United States, 030104 developmental biology, Reproductive Medicine, chemistry, 030220 oncology & carcinogenesis, Cancer research, RC870-923, medicine.symptom, business, medicine.drug, Research Article

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96352efa42d651655e10ac31beee7b74Test
https://pure.manchester.ac.uk/ws/files/196449568/s12894_021_00856_x.pdfTest

3

Clinical Development of Novel Drug–Radiotherapy Combinations

المؤلفون: Richard D. Baird, Gideon M. Blumenthal, Patricia A. Spears, Phuoc T. Tran, Saif S Ahmad, Amanda J. Walker, Timothy M Illidge, Stephen M. Hahn, Marka R Crittenden, Helen Bulbeck, Ricky A. Sharma, Theodore S. Lawrence, Kaye J. Williams, Paul G. Kluetz

المساهمون: Baird, Richard D [0000-0001-7071-6483], Apollo - University of Cambridge Repository

المصدر: Clinical Cancer Research. 25:1455-1461

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560d42e182073290ed1add498495c075Test
https://doi.org/10.1158/1078-0432.ccr-18-2466Test

4

Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers

المؤلفون: Kaye J. Williams, Roben G. Gieling

المصدر: International Journal of Molecular Sciences

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Review, CAIX/XII inhibitors, Catalysis, S4, Inorganic Chemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Breast cancer, Downregulation and upregulation, medicine, Humans, Physical and Theoretical Chemistry, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Molecular Biology, Spectroscopy, Carbonic Anhydrases, Cisplatin, chemistry.chemical_classification, Sulfonamides, hypoxia, U-104, Phenylurea Compounds, Organic Chemistry, Sulfonamide (medicine), C100, ureido-substituted sulfamate, General Medicine, medicine.disease, C700, Small Cell Lung Carcinoma, 3. Good health, Computer Science Applications, B900, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, ureido-substituted benzenesulfonamide, Sulfonic Acids, SLC-0111, medicine.drug, carbonic anhydrases (CAs)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1700d8ff8595447ec0bb0f4c59cbb76Test

5

Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry

المؤلفون: Jesús M. Pradillo, Hervé Boutin, Fiona Henderson, Michael Kassiou, Philippa J. Hart, Lidan Christie, Adam McMahon, Kaye J. Williams

المصدر: Henderson, F, Hart, P J, Pradillo, J M, Kassiou, M, Christie, L, Williams, K J, Boutin, H & McMahon, A 2018, ' Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry ', Rapid Communications in Mass Spectrometry, vol. 32, no. 9, pp. 721-729 . https://doi.org/10.1002/rcm.8090Test

مصطلحات موضوعية: 0301 basic medicine, Time Factors, medicine.medical_treatment, Mass spectrometry, Mass spectrometry imaging, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, In vivo, Journal Article, medicine, Animals, Rats, Wistar, Stroke, Spectroscopy, Neuroinflammation, medicine.diagnostic_test, Chemistry, Organic Chemistry, Brain, Lysophosphatidylcholines, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Sphingomyelins, Pyrimidines, 030104 developmental biology, Positron emission tomography, Positron-Emission Tomography, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Phosphatidylcholines, Pyrazoles, Stroke recovery, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a94233abd14037a23a7b12ba73b0ec7Test
https://doi.org/10.1002/rcm.8090Test

6

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

المؤلفون: Hannah J. Gregson, Kay Marshall, Stephen A Roberts, Sarah Kitson, Vanitha N Sivalingam, Kaye J. Williams, Amy L. Chadwick, James Bolton, Ayse Latif, Emma J Crosbie, Rhona J McVey, Ian J. Stratford

المصدر: BMC Clinical Pathology, Vol 17, Iss 1, Pp 1-10 (2017)
BMC Clinical Pathology
Latif, A, Chadwick, A L, Kitson, S J, Gregson, H J, Sivalingam, V N, Bolton, J, McVey, R J, Roberts, S A, Marshall, K M, Williams, K J, Stratford, I J & Crosbie, E J 2017, ' Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer ', BMC Clinical Pathology, vol. 17, pp. 27 . https://doi.org/10.1186/s12907-017-0067-7Test

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2988b7c7ec7d61abc52b001e69a8d9acTest
http://link.springer.com/article/10.1186/s12907-017-0067-7Test

7

Novel carbonic anhydrase IX-targeted therapy enhances the anti-tumour effects of cisplatin in small cell lung cancer

المؤلفون: Roben G. Gieling, Tiffany-Jayne Allen, Claudiu T. Supuran, Suzanne Meredith, Jennifer L. Bryant, Brian A. Telfer, Kaye J. Williams, Leanne Walker, Anne White

المصدر: International Journal of Cancer. 142:191-201

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5ae218f63a30b511badd173a2a79b1a0Test
https://doi.org/10.1002/ijc.31042Test

8

Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours

المؤلفون: Gabriella Forte, Brian A. Telfer, Ian Kamaly-Asl, Aiyin Liao, Claire O'Leary, Helen Parker, Brian W. Bigger, Kaye J. Williams, A. Saam Youshani, Samuel Rowlston

المصدر: Journal of Neuroinflammation
Youshani, A S, Rowlston, S, O'Leary, C, Forte, G, Parker, H, Liao, A, Telfer, B, Williams, K, Kamaly-Asl, I D & Bigger, B W 2019, ' Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours ', Journal of Neuroinflammation, vol. 16, no. 1, 25 . https://doi.org/10.1186/s12974-019-1410-yTest
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: 0301 basic medicine, Lydia Becker Institute, medicine.medical_treatment, lcsh:RC346-429, Mice, 0302 clinical medicine, Immunity, Cellular, Brain Neoplasms, General Neuroscience, Haematopoiesis, Cytokine, medicine.anatomical_structure, Neurology, Radiation Chimera, Cytokines, Female, Microglia, Chimeric mouse model, medicine.drug, Immunology, Bone Marrow Cells, 03 medical and health sciences, Cellular and Molecular Neuroscience, Immune system, Antigen, ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation, Cell Line, Tumor, medicine, Animals, Head-shielded irradiation, Antineoplastic Agents, Alkylating, Busulfan, Neuroinflammation, lcsh:Neurology. Diseases of the nervous system, Inflammation, business.industry, Chimera, Research, Macrophages, Non-myeloablative conditioning, Mice, Inbred C57BL, 030104 developmental biology, Cancer research, Leukocyte Common Antigens, Bone marrow, business, Glioblastoma, 030217 neurology & neurosurgery, Whole Bone Marrow, Neoplasm Transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34af8a6d27ae53e8d5199c4dd9f7f6dTest
http://europepmc.org/articles/PMC6362590Test

9

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

المؤلفون: Manal Mehibel, Fernando Ortiz-Martinez, Catharine M L West, Nadine Voelxen, Brian A. Telfer, Amy Boyers, Ian J. Stratford, Kaye J. Williams, Susan E. Critchlow, Wolfgang Mueller-Klieser, Amy L. Chadwick

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Mehibel, M, Ortiz-martinez, F, Voelxen, N, Boyers, A, Chadwick, A, Telfer, B A, Mueller-klieser, W, West, C M, Critchlow, S E, Williams, K J & Stratford, I J 2018, ' Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters ', Scientific Reports, vol. 8, no. 1, 16804 . https://doi.org/10.1038/s41598-018-35103-1Test

مصطلحات موضوعية: Monocarboxylic Acid Transporters, 0301 basic medicine, Statin, medicine.drug_class, lcsh:Medicine, Pyrimidinones, Thiophenes, Article, Oxidative Phosphorylation, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Lactic Acid, Precision Medicine, lcsh:Science, Multidisciplinary, Manchester Cancer Research Centre, biology, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, lcsh:R, Head and neck cancer, Cancer, Prognosis, medicine.disease, Head and neck squamous-cell carcinoma, 030104 developmental biology, Monocarboxylate transporter 1, Head and Neck Neoplasms, Simvastatin, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Cancer research, Biomarker (medicine), lcsh:Q, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Biomarkers, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d742e81eac83a56f7780095c7b65244Test
https://doi.org/10.1038/s41598-018-35103-1Test

10

Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish

المصدر: Henderson, F, Johnston, H, Badrock, A, Jones, E, Forster, D, Nagaraju, R, Evangelou, C, Kamarashev, J, Green, M, Fairclough, M, Barinaga-Rementeria, I, He, S, Jagalska, E S, Hollywood, K, Dunn, W, Spaink, H P, Smith, M, Lorigan, P, Claude, E, Williams, K, Mcmahon, A & Hurlstone, A 2019, ' Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish ', Cancer Research, vol. 79, no. 9, pp. 2136-2151 . https://doi.org/10.1158/0008-5472.can-18-2409Test
Cancer Research, 79(9), 2136-2151
Cancer Research

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Phospholipid, Glycerophospholipids, Palmitic acid, Transcriptome, Mass Spectrometry Imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Manchester Institute of Biotechnology, Tumor Cells, Cultured, Animals, Humans, Metabolomics, Zebrafish, Melanoma, chemistry.chemical_classification, Lipoprotein lipase, Microphthalmia-Associated Transcription Factor, biology, Fatty Acids, Fatty acid, Lipid metabolism, Zebrafish Proteins, biology.organism_classification, Lipid Metabolism, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Fatty acid synthase, Lipoprotein Lipase, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, ras Proteins, Melanocytes, LPL, Fatty Acid Synthases, Energy Metabolism, Transcriptome Analysis, Fatty Acid

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3528b41f2ca92becf293b08a708b55Test
https://pubmed.ncbi.nlm.nih.gov/30862716Test

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