Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy
| العنوان: | Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy |
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| المؤلفون: | Satoko Arakawa, Hirofumi Yamaguchi, Shigeomi Shimizu, Shinya Honda |
| المصدر: | Proceedings of the Japan Academy. Series B, Physical and Biological Sciences |
| بيانات النشر: | Japan Academy, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, reticulocytes, Endosome, ATG5, Golgi Apparatus, Atg5-independent autophagy, General Physics and Astronomy, Lipid-anchored protein, Review, Protein degradation, Autophagy-Related Protein 7, Autophagy-Related Protein 5, 03 medical and health sciences, 0302 clinical medicine, Autophagy, Animals, Humans, alternative autophagy, Chemistry, Vesicle, Autophagosomes, General Medicine, Cell biology, 030104 developmental biology, Alternative complement pathway, Lysosomes, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery |
| الوصف: | ATG5 and ATG7 are considered to be essential molecules for the induction of autophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagic protein degradation when subjected to certain types of stress. Although the lipidation of LC3 is accepted as a good indicator of autophagy, this did not occur during ATG5/ATG7-independent alternative autophagy. Unlike conventional autophagy, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of the phagophores with vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the ATG5/ATG7-dependent conventional pathway and an ATG5/ATG7-independent alternative pathway. |
| تدمد: | 1349-2896 0386-2208 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824d48fb35265c627d202f553e7ce3a8Test https://doi.org/10.2183/pjab.93.023Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....824d48fb35265c627d202f553e7ce3a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13492896 03862208 |
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