Model-Based Magnetization Transfer Imaging Markers to Characterize Patients and Asymptomatic Gene Carriers in Huntington's Disease
| العنوان: | Model-Based Magnetization Transfer Imaging Markers to Characterize Patients and Asymptomatic Gene Carriers in Huntington's Disease |
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| المؤلفون: | Jean-Marc Burgunder, Claus Kiefer, Roland Wiest |
| المصدر: | Wiest, Roland; Burgunder, Jean-Marc; Kiefer, Claus (2017). Model-Based Magnetization Transfer Imaging Markers to Characterize Patients and Asymptomatic Gene Carriers in Huntington's Disease. Frontiers in neurology, 8(465), p. 465. Frontiers Media S.A. 10.3389/fneur.2017.00465 <http://dx.doi.org/10.3389/fneur.2017.00465Test> Frontiers in Neurology Frontiers in Neurology, Vol 8 (2017) |
| بيانات النشر: | Frontiers Media S.A., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Pathology, medicine.medical_specialty, Caudate nucleus, 610 Medicine & health, Disease, Neuroprotection, Asymptomatic, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Huntington's disease, Neuroimaging, Internal medicine, medicine, magnetization transfer imaging, Magnetization transfer, pre-Huntington’s disease gene carriers, Disease burden, lcsh:Neurology. Diseases of the nervous system, Original Research, business.industry, caudate nucleus, medicine.disease, 030104 developmental biology, Neurology, classification, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, Neuroscience, Huntington’s disease |
| الوصف: | BACKGROUND AND PURPOSE Huntington's disease (HD) is a chronic progressive neurodegenerative disorder with a long presymptomatic period that opens a window for potential therapies aimed at neuroprotection. Neuroimaging offers the potential to monitor disease-related progression of the disease burden (DB) using model-based magnetization transfer imaging. MATERIALS AND METHODS We have conducted a cross-sectional study to stratify healthy age-matched controls, premanifest and symptomatic HD patients (n = 30) according to their macromolecular depositions in the caudate nucleus. We employed a binary spin-bath magnetization transfer (MT) method for a quantitative description of macromolecule deposits and interactions with their adjacent environment. RESULTS A region-of-interest based fuzzy clustering analysis identified representative clusters for several stages of the disease course related to its progression: one cluster represented subjects with a high DB 230 and healthy controls. Three further clusters represented transition zones between both DB levels (230-268) consisting of presymptomatic carriers with DB values increasing with decreasing distance from the cluster that indicated low DB and healthy age-matched controls. CONCLUSION The proposed binary spin-bath MT method offers the potential to monitor DB and progression in HD. The method may augment qualitative MT techniques since it depicts tissue changes related to interactions between macromolecules and protons in disease specific brain regions that follow the neurodegenerative process. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744964c3907f82a52f7310696a226baaTest https://boris.unibe.ch/105631/1/fneur-08-00465.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....744964c3907f82a52f7310696a226baa |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |