Major CD4 T-cell depletion and immune senescence in a patient with chronic granulomatous disease
| العنوان: | Major CD4 T-cell depletion and immune senescence in a patient with chronic granulomatous disease |
|---|---|
| المؤلفون: | Adriana S. Albuquerque, Susana M. Fernandes, Rita Tendeiro, Rémi Cheynier, Margarida Lucas, Susana L. Silva, Rui M. M. Victorino, Ana E. Sousa |
| المساهمون: | Repositório da Universidade de Lisboa |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Frontiers in Immunology, Vol 8 (2017) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Genetic enhancement, Immunology, Case Report, Context (language use), Biology, CD4 T-cell lymphopenia, interleukin-17, 03 medical and health sciences, Chronic granulomatous disease, Immune system, medicine, Immunology and Allergy, Primary immunodeficiency, Immune senescence, medicine.disease, Respiratory burst, Transplantation, 030104 developmental biology, Genetic phagocytic defect, Interleukin 17, gut mucosa, lcsh:RC581-607, Reactive oxygen species |
| الوصف: | Copyright © 2017 Albuquerque, Fernandes, Tendeiro, Cheynier, Lucas, Silva, Victorino and Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Chronic granulomatous disease (CGD) results from primary defects in phagocytic reactive oxygen species (ROS) production. T-cell evaluation is usually neglected during patients' follow-up, although T-cell depletion has been reported in CGD through unknown mechanisms. We describe here a 36-year-old patient with X-linked CGD with severe CD4 T-cell depletion AA, SF, RT, and SS received scholarships from Fundação para a Ciência e Tecnologia (FCT), Portugal. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c793584a4b7872ba113e57babc902b2Test https://hdl.handle.net/10451/28767Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4c793584a4b7872ba113e57babc902b2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |