Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes
| العنوان: | Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes |
|---|---|
| المؤلفون: | Kristian F. Hanssen, James A. Scardo, Jeremy Y. Yu, Christopher E. Aston, Judith Shary, Alison Nankervis, Satish K. Garg, Timothy J. Lyons, Clare B. Kelly, Alicia J. Jenkins, Carol L. Wagner, Samar M. Hammad, Misti J. Leyva |
| المصدر: | Nutrients, Vol 12, Iss 2048, p 2048 (2020) Kelly, C B, Wagner, C L, Shary, J R, Leyva, M J, Yu, J Y, Jenkins, A J, Nankervis, A J, Hanssen, K F, Garg, S K, Scardo, J A, Hammad, S M, Aston, C E & Lyons, T J 2020, ' Vitamin D Metabolites and Binding Protein Predict Preeclampsia in Women with Type 1 Diabetes ', Nutrients, vol. 12, no. 7, 2048 . https://doi.org/10.3390/nu12072048Test Nutrients Volume 12 Issue 7 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, 1,25-dihydroxyvitamin D, Vitamin D-binding protein, type 1 diabetes, Pregnancy in Diabetics, vitamin D, Vitamin D binding protein, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, vitamin D binding protein, Medicine, Longitudinal Studies, Vitamin D, Nutrition and Dietetics, Vitamin D-Binding Protein, 25-hydroxyvitamin D, Type 1 diabetes, Pregnancy Trimester, Second, Gestation, Female, pregnancy, lcsh:Nutrition. Foods and food supply, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, lcsh:TX341-641, Article, vitamin D deficiency, Preeclampsia, preeclampsia, Young Adult, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Diabetes mellitus, Internal medicine, Vitamin D and neurology, Humans, business.industry, Vitamin D Deficiency, medicine.disease, Pregnancy Trimester, First, Diabetes Mellitus, Type 1, 030104 developmental biology, Endocrinology, business, Biomarkers, Food Science |
| الوصف: | The risk for preeclampsia (PE) is enhanced ~4-fold by the presence of maternal type 1 diabetes (T1DM). Vitamin D is essential for healthy pregnancy. We assessed the total, bioavailable, and free concentrations of plasma 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and vitamin D binding protein (VDBP) at ~12, ~22, and ~32 weeks&rsquo gestation (&ldquo Visits&rdquo (V) 1, 2, and 3, respectively) in 23 T1DM women who developed PE, 24 who remained normotensive, and 19 non-diabetic, normotensive women (reference controls). 25(OH)D deficiency was more frequent in diabetic than non-diabetic women (69% vs. 22%, p < 0.05), but no measure of 25(OH)D predicted PE. By contrast, higher 1,25(OH)2D concentrations at V2 (total, bioavailable, and free: p < 0.01) and V3 (bioavailable: p < 0.05 free: p < 0.01), lower concentrations of VDBP at V3 (p < 0.05), and elevated ratios of 1,25(OH)2D/VDBP (V2, V3: p < 0.01) and 1,25(OH)2D/25(OH)D (V3, p < 0.05) were all associated with PE, and significance persisted in multivariate analyses. In summary, in women with T1DM, concentrations of 1,25(OH)2D were higher, and VDBP lower, in the second and third trimesters in women who later developed PE than in those who did not. 1,25(OH)2D may serve as a new marker for PE risk and could be implicated in pathogenesis. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f119bcf1f3e9ca2022cff10fc5dd28Test https://www.mdpi.com/2072-6643/12/7/2048Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f4f119bcf1f3e9ca2022cff10fc5dd28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
|---|