نتائج البحث - "Brain Neoplasms: genetics"

1

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion

المؤلفون: Daniel Pérez-Hernández, Arnon Møldrup Knudsen, Rolf Bjerkvig, Arnaud Muller, Carina Fabian, Anna Golebiewska, Sophie Rodius, Anne Schuster, Eliane Klein, Ann Christin Hau, Petr V. Nazarov, Monika Dieterle, Barbara Klink, Gunnar Dittmar, Virginie Neirinckx, Bjarne Winther Kristensen, Simone P. Niclou, Christel Herold-Mende, Anais Oudin

المصدر: Nature Communications
Schuster, A, Klein, E, Neirinckx, V, Knudsen, A M, Fabian, C, Hau, A C, Dieterle, M, Oudin, A, Nazarov, P V, Golebiewska, A, Muller, A, Perez-Hernandez, D, Rodius, S, Dittmar, G, Bjerkvig, R, Herold-Mende, C, Klink, B, Kristensen, B W & Niclou, S P 2020, ' AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion ', Nature Communications, vol. 11, 6366 . https://doi.org/10.1038/s41467-020-20029-yTest
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

مصطلحات موضوعية: 0301 basic medicine, General Physics and Astronomy, Transcriptome, Mice, 0302 clinical medicine, Cell Movement, Transcriptional regulation, Nuclear protein, Cancer, Regulation of gene expression, Zinc finger, Multidisciplinary, Brain Neoplasms, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Heterografts, Fibronectins/genetics, Cell Adhesion Molecules/genetics, Science, Protein domain, Brain tumor, Transcription Factors/genetics, Collagen Type VI, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Collagen Type VI/genetics, Protein Domains, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Invasiveness, Brain Neoplasms/genetics, General Chemistry, medicine.disease, Glioblastoma/genetics, nervous system diseases, Fibronectins, CNS cancer, 030104 developmental biology, Cancer research, Neoplasm Invasiveness/genetics, Glioblastoma, Cell Adhesion Molecules, Nuclear localization sequence, DNA-Binding Proteins/genetics, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d2552eaaa2f15c1c733ad47bd2cf1cTest
http://europepmc.org/articles/PMC7732990Test

2

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

المؤلفون: Jannick Brennum, Jiri Bartek, Diana Aguilar-Morante, Petra Hamerlik, Elisabeth Anne Adanma Obara, Rikke Darling Rasmussen, Lucie Tučková, Alex Frias, Robert Strauss, Henriette Pedersen, Christoffel Dinant, Kirstine Juul Elbæk, Yi Chieh Lim, Kamilla E. Jensen, Kristoffer Vitting-Serup, Jane Skjøth-Rasmussen, Lina Vardouli

المصدر: Obara, E A A, Aguilar-Morante, D, Rasmussen, R D, Frias, A, Vitting-Serup, K, Lim, Y C, Elbæk, K J, Pedersen, H, Vardouli, L, Jensen, K E, Skjoth-Rasmussen, J, Brennum, J, Tuckova, L, Strauss, R, Dinant, C, Bartek, J & Hamerlik, P 2020, ' SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells ', Nature Communications, vol. 11, 4709 . https://doi.org/10.1038/s41467-020-18549-8Test
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: 0301 basic medicine, Genome instability, DNA Repair, General Physics and Astronomy, Apoptosis, Radiation Tolerance, Transcriptome, Mice, chemistry.chemical_compound, 0302 clinical medicine, Radiation, Ionizing, RNA, Small Interfering, lcsh:Science, RNA, Small Interfering/genetics, Regulation of gene expression, Mice, Inbred BALB C, Multidisciplinary, Neoplastic Stem Cells/pathology, Brain Neoplasms, Cancer stem cells, BRCA1 Protein, Cell biology, Chromatin, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Heterografts, Female, endocrine system, DNA repair, Science, Transcription Factors/genetics, Biology, Article, Genomic Instability, General Biochemistry, Genetics and Molecular Biology, Chromatin remodeling, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Gene silencing, Gene Silencing, Homologous recombination, Brain Neoplasms/genetics, fungi, Cell Cycle Checkpoints, General Chemistry, Glioblastoma/genetics, HEK293 Cells, 030104 developmental biology, chemistry, lcsh:Q, Glioblastoma, DNA, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7eccf9fad8a44a46aaf6c842ec456eTest
https://doi.org/10.1038/s41467-020-18549-8Test

3

The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth

المؤلفون: Tian Shu Fan, Timo W.M. De Groof, Diane Van Hoorick, Henry F. Vischer, Maarten P. Bebelman, Laura Smits-de Vries, Afsar Rahbar, Marco Siderius, Jeffrey R. van Senten, Tonny Lagerweij, Raimond Heukers, Jody van Offenbeek, Raymond H. de Wit, Thomas Wurdinger, Rob Leurs, Cecilia Söderberg-Nauclér, Joao Vieira, Martine J. Smit, Sabrina M. de Munnik

المساهمون: Basic (bio-) Medical Sciences, CCA - Cancer biology and immunology, Neurosurgery, AIMMS, Medicinal chemistry

المصدر: Oncogene
Oncogene, 37(30), 4110-4121. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 37, no. 30, pp. 4110-4121 . https://doi.org/10.1038/s41388-018-0255-7Test
Oncogene, 2018(30), 1-12. Nature Publishing Group
Heukers, R, Fan, T S, de Wit, R H, van Senten, J R, de Groof, T W M, Bebelman, M P, Lagerweij, T, Vieira, J, de Munnik, S M, Smits-de Vries, L, van Offenbeek, J, Rahbar, A, van Hoorick, D, Söderberg-Naucler, C, Würdinger, T, Leurs, R, Siderius, M, Vischer, H F & Smit, M J 2018, ' The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth ', Oncogene, vol. 2018, no. 30, pp. 1-12 . https://doi.org/10.1038/s41388-018-0255-7Test

مصطلحات موضوعية: 0301 basic medicine, Human cytomegalovirus, Cancer Research, Chemokine, Cytomegalovirus, Chemokine receptor, Mice, Chlorocebus aethiops, Receptors, Chemokine/genetics, biology, Brain Neoplasms, 3. Good health, Viral Proteins/genetics, COS Cells, Receptors, Virus, Female, Receptors, Chemokine, Signal transduction, Signal Transduction, Receptors, Virus/genetics, Mice, Nude, Article, Cercopithecus aethiops, Cell Line, 03 medical and health sciences, Cell Proliferation/genetics, Viral Proteins, SDG 3 - Good Health and Well-being, Neurosphere, Genetics, medicine, Animals, Humans, Molecular Biology, Cell Proliferation, Brain Neoplasms/genetics, HEK 293 cells, medicine.disease, Cytomegalovirus/genetics, Glioblastoma/genetics, 030104 developmental biology, HEK293 Cells, Chemokine binding, Cell culture, biology.protein, Cancer research, NIH 3T3 Cells, Signal Transduction/genetics, Glioblastoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d2b143f496bc5734d97f476890189dTest
http://europepmc.org/articles/PMC6062493Test

4

The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033

المساهمون: Neurology, CCA - Cancer biology and immunology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy

المصدر: Acta Neuropathologica, 135(4), 601-615
Acta Neuropathologica, 135, 4, pp. 601-615
Acta Neuropathologica, 135(4), 601-615. Springer Verlag
Acta Neuropathologica, 135, 601-615
Acta Neuropathologica, 135(4), 601-615. SPRINGER
Bady, P, Kurscheid, S, Delorenzi, M, Gorlia, T, van den Bent, M J, Hoang-Xuan, K, Vauléon, É, Gijtenbeek, A, Enting, R, Thiessen, B, Chinot, O, Dhermain, F, Brandes, A A, Reijneveld, J C, Marosi, C, Taphoorn, M J B, Wick, W, von Deimling, A, French, P, Stupp, R, Baumert, B G & Hegi, M E 2018, ' The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033 ', Acta Neuropathologica, vol. 135, no. 4, pp. 601-615 . https://doi.org/10.1007/s00401-018-1810-6Test
Acta Neuropathologica, 135(4), 601-615. Springer, Cham
Acta neuropathologica, vol. 135, no. 4, pp. 601-615
Acta Neuropathologica, 135(4), 601-615. Springer-Verlag

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Epigenesis, Genetic, MISMATCH REPAIR, 0302 clinical medicine, Promoter Regions, Genetic, DNA Modification Methylases, DNA methylation, Brain Neoplasms, METHYLATION, TEMOZOLOMIDE, Glioma, Methylation, TUMORS, Isocitrate Dehydrogenase, Progression-Free Survival, 3. Good health, Treatment Outcome, Isocitrate dehydrogenase, CpG site, 030220 oncology & carcinogenesis, Female, DNA mismatch repair, Adult, Antineoplastic Agents, Alkylating/therapeutic use, Brain Neoplasms/genetics, Brain Neoplasms/pathology, Brain Neoplasms/therapy, CpG Islands, DNA, DNA Methylation/drug effects, DNA Methylation/radiation effects, DNA Modification Methylases/genetics, DNA Repair Enzymes/genetics, Discoidin Domain Receptors/genetics, Glioma/genetics, Glioma/pathology, Glioma/therapy, Humans, Isocitrate Dehydrogenase/genetics, Neoplasm Grading, Temozolomide/therapeutic use, Tumor Suppressor Proteins/genetics, DDR genes, Low-grade glioma, MGMT-STP27, Randomized trial, TMZ, SENSITIVITY, MGMT, medicine.drug, RADIOTHERAPY, EXPRESSION, medicine.medical_specialty, GLIOBLASTOMA, Other Research Donders Center for Medical Neuroscience [Radboudumc 0], Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, All institutes and research themes of the Radboud University Medical Center, Internal medicine, medicine, Progression-free survival, Antineoplastic Agents, Alkylating, Discoidin Domain Receptors, neoplasms, Temozolomide, business.industry, Tumor Suppressor Proteins, medicine.disease, DNA Repair Enzymes, 030104 developmental biology, CELLS, Neurology (clinical), business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422a15982be72bdd3ae70ac6b3775603Test
https://hdl.handle.net/2066/190470Test

5

Correlation of immune phenotype with IDH mutation in diffuse glioma

المؤلفون: Philip Kresl, Adelheid Wöhrer, Christine Marosi, Barbara Kiesel, Dorothee Wilhelm, Sebastian Kurscheid, Anna S. Berghoff, Georg Widhalm, Monika E. Hegi, Orsolya Rajky, Matthias Preusser

المصدر: Neuro-oncology, vol. 19, no. 11, pp. 1460-1468

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, B7-H1 Antigen, Cohort Studies, 03 medical and health sciences, Diffuse Glioma, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, PD-L1, Glioma, Gene expression, Biomarkers, Tumor, medicine, Humans, Promoter Regions, Genetic, Aged, Tumor microenvironment, biology, Brain Neoplasms, Tumor-infiltrating lymphocytes, Editorials, B7-H1 Antigen/genetics, B7-H1 Antigen/metabolism, Biomarkers, Tumor/genetics, Biomarkers, Tumor/metabolism, Brain Neoplasms/genetics, Brain Neoplasms/immunology, Brain Neoplasms/metabolism, Brain Neoplasms/pathology, Female, Follow-Up Studies, Glioma/genetics, Glioma/immunology, Glioma/metabolism, Glioma/pathology, Isocitrate Dehydrogenase/genetics, Lymphocytes, Tumor-Infiltrating/immunology, Lymphocytes, Tumor-Infiltrating/metabolism, Middle Aged, Mutation, Phenotype, Prognosis, IDH mutation, glioblastoma, immune microenvironment, low grade glioma, promoter methylation, Promoter, Methylation, medicine.disease, Isocitrate Dehydrogenase, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Neurology (clinical)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b16d064c69a2632b0ae79faf35623a5Test
https://doi.org/10.1093/neuonc/nox054Test

6

The RNA binding protein IMP2 preserves glioblastoma stem cells by preventing let-7 target gene silencing

المؤلفون: Ivan Stamenkovic, Mario L. Suvà, Paolo Provero, Michalina Janiszewska, Nils Degrauwe, Tommy Beat Schlumpf, Alexandra Cauderay, Renato Paro, Patricia Martin, Nicolo Riggi

المصدر: Genes and Development
Cell Reports
Cell Reports, Vol 15, Iss 8, Pp 1634-1647 (2016)
Cell reports, vol. 15, no. 8, pp. 1634-1647
Cell Reports, 15 (8)

مصطلحات موضوعية: 0301 basic medicine, Cellular differentiation, Biology, LIN28, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Neural Stem Cells, Cancer stem cell, Spheroids, Cellular, Cell Adhesion, Humans, Gene silencing, Gene Silencing, RNA, Messenger, lcsh:QH301-705.5, Regulation of gene expression, Base Sequence, Brain Neoplasms, RNA-Binding Proteins, Embryonic stem cell, Neural stem cell, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, lcsh:Biology (General), Neoplastic Stem Cells, Cancer research, Stem cell, Glioblastoma, Brain Neoplasms/genetics, Brain Neoplasms/pathology, Glioblastoma/genetics, Glioblastoma/pathology, MicroRNAs/genetics, MicroRNAs/metabolism, Neoplastic Stem Cells/metabolism, Neoplastic Stem Cells/pathology, Neural Stem Cells/metabolism, Protein Binding, RNA, Messenger/genetics, RNA, Messenger/metabolism, RNA-Binding Proteins/metabolism, Spheroids, Cellular/pathology

وصف الملف: application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70f1f268d7b92b94859d969d4856aa8Test

7

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

المؤلفون: Christina Dahl, Christer Lundell-Ek, Henrik J. Ditzel, Jann Mortensen, Karine N. Dzhandzhugazyan, Line Bille Madsen, Johnny Jon Fang, Helle Broholm, Walter Fischer, Morten F. Gjerstorff, Tim Lundby, Ian Law, Per Guldberg, Rikke Sick Andersen, Martin Roland Jensen, Alexei F. Kirkin, Aase Wagner

المصدر: Kirkin, A F, Dzhandzhugazyan, K N, Guldberg, P, Fang, J J, Andersen, R S, Dahl, C, Mortensen, J, Lundby, T, Wagner, A, Law, I, Broholm, H, Madsen, L, Lundell-Ek, C, Gjerstorff, M F, Ditzel, H J, Jensen, M R & Fischer, W 2018, ' Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells ', Nature Communications, vol. 9, 785 . https://doi.org/10.1038/s41467-018-03217-9Test
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Kirkin, A F, Dzhandzhugazyan, K N, Guldberg, P, Fang, J J, Andersen, R S, Dahl, C, Mortensen, J, Lundby, T, Wagner, A, Law, I, Broholm, H, Madsen, L, Lundell-Ek, C, Gjerstorff, M F, Ditzel, H J, Jensen, M R & Fischer, W 2018, ' Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells ', Nature Communications, vol. 9, no. 1, 785 . https://doi.org/10.1038/s41467-018-03217-9Test

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_treatment, General Physics and Astronomy, Immunotherapy, Adoptive, 0302 clinical medicine, Cancer immunotherapy, Cytotoxic T cell, Prospective Studies, lcsh:Science, Multidisciplinary, Brain Neoplasms, T-Lymphocytes, Helper-Inducer, Antigens, Neoplasm/genetics, 030220 oncology & carcinogenesis, Female, Adult, Science, Antigen-Presenting Cells, DNA/genetics, Article, General Biochemistry, Genetics and Molecular Biology, Young Adult, 03 medical and health sciences, T-Lymphocytes, Helper-Inducer/immunology, Antigen, Antigens, Neoplasm, Antigen-Presenting Cells/immunology, medicine, Humans, Antigen-presenting cell, Brain Neoplasms/genetics, business.industry, Cancer, DNA, General Chemistry, Immunotherapy, DNA Methylation, T-Lymphocytes, Cytotoxic/immunology, medicine.disease, Glioblastoma/genetics, 030104 developmental biology, DNA demethylation, Cancer cell, Cancer research, lcsh:Q, Glioblastoma, business, T-Lymphocytes, Cytotoxic

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2073161fab54b049c7d89cd5b4119ccTest
https://doi.org/10.1038/s41467-018-03217-9Test

8

WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1

المؤلفون: Monika E. Hegi, Premnath Rajakannu, Marta Lai, Irene Vassallo, Marie-France Hamou, Pascal O. Zinn

المصدر: Oncogene
Oncogene, vol. 35, no. 1, pp. 12-21

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Adaptor Proteins, Signal Transducing/genetics, WIF1, Mice, Cell Movement, Glioblastoma/metabolism, Wnt Signaling Pathway, CIBM-AIT, Gene knockdown, Brain Neoplasms, Wnt signaling pathway, LRP6, LRP5, Cell migration, Adaptor Proteins, Signal Transducing/biosynthesis, Animals, Brain Neoplasms/genetics, Brain Neoplasms/metabolism, Cell Line, Tumor, Cell Movement/physiology, Cell Proliferation/physiology, Down-Regulation, Gene Expression Regulation, Neoplastic, Glioblastoma/genetics, Heterografts, Humans, Mice, Nude, Proto-Oncogene Proteins/genetics, Proto-Oncogene Proteins/metabolism, RNA, Long Noncoding/genetics, RNA, Long Noncoding/metabolism, Repressor Proteins/biosynthesis, Repressor Proteins/genetics, Signal Transduction, Wnt Proteins/genetics, Wnt Proteins/metabolism, WNT5A, Brain Neoplasms/pathology, RNA, Long Noncoding, Signal transduction, Biology, Wnt-5a Protein, 03 medical and health sciences, Proto-Oncogene Proteins, Genetics, Molecular Biology, Adaptor Proteins, Signal Transducing, Cell Proliferation, Repressor Proteins, Wnt Proteins, Glioblastoma/pathology, 030104 developmental biology, Immunology, Cancer research, Glioblastoma

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19548516f268809303ffcdcd42f25930Test

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