CD4/CD8 + T cells, DC subsets, Foxp3, and IDO expression are predictive indictors of gastric cancer prognosis
| العنوان: | CD4/CD8 + T cells, DC subsets, Foxp3, and IDO expression are predictive indictors of gastric cancer prognosis |
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| المؤلفون: | Yao Sun, Juntian Liu, Zhiyong Yuan, Fangxuan Li, Wengui Xu, Jinchao Huang |
| المصدر: | Cancer Medicine, Vol 8, Iss 17, Pp 7330-7344 (2019) Cancer Medicine |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Cancer Research, Kaplan-Meier Estimate, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, 0302 clinical medicine, Tumor Microenvironment, Medicine, Cytotoxic T cell, Indoleamine 2,3-dioxygenase, Original Research, Cancer Biology, Stomach, FOXP3, Cell Differentiation, Forkhead Transcription Factors, regulator T cell, Middle Aged, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, indoleamine 2,3‐dioxygenase, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Female, dendritic cell, lcsh:RC254-282, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Gastrectomy, Stomach Neoplasms, Biomarkers, Tumor, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Radiology, Nuclear Medicine and imaging, Aged, Neoplasm Staging, Tumor microenvironment, business.industry, gastric cancer, Cancer, Dendritic cell, Dendritic Cells, medicine.disease, 030104 developmental biology, Tumor progression, Cancer research, business, CD8 |
| الوصف: | Background The tumor microenvironment represents an abnormal niche containing numerous factors, such as T cells, dendritic cells (DCs), regulatory T cells (Tregs), and indoleamine 2,3‐dioxygenase (IDO), involved in maintaining immune homeostasis and tolerance. All these factors may influence the choice of therapy and the clinical outcomes. Methods Flow cytometry was performed to identify CD4+/CD8 + T cells and DCs, and immunohistochemistry was used to evaluate IDO and Forkhead Box P3 (Foxp3) expression; these experiments were performed in order to explore the clinical and prognostic significance of CD4/CD8 + T cells, DCs, Tregs, and IDO expression in gastric carcinoma. Results Smaller tumor size was correlated with higher expression levels of peripheral CD4 + T cells (P = .003) and CD8 + T cells (P = .002), and lower IDO expression (P = .044) in tumors. Well‐differentiated gastric carcinomas displayed higher peripheral (P = .029) and tumor‐infiltrating CD4 + T cell (P = .009) populations and a higher tumor‐infiltrating DC1/DC2 ratio (P = .048). Gastric cancer in the early T stages exhibited higher populations of peripheral DC2s (P = .044) and a higher tumor‐infiltrating DC1/DC2 ratio (P = .012). Gastric cancer at the N0 stage had lower tumor‐infiltrating DC2s (P = .032) and a higher DC1/DC2 ratio (P = .037). IDO expression was positively correlated with tumor‐infiltrating Foxp3 + Tregs (P The tumor microenvironment represents an abnormal niche containing numerous factors, such as T cells, DCs, Tregs, and IDO, involved in maintaining immune homeostasis and tolerance. We confirmed that the expression levels of peripheral and tumor‐infiltrating DC2s, CD4+/CD8 + T cells, Foxp3 + Tregs, and IDO were correlated with each other as well as with clinicopathological characters and gastric cancer prognosis. |
| اللغة: | English |
| تدمد: | 2045-7634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369c9a35ffde691843a212f81236239eTest https://doaj.org/article/8d842ed36808410aaa066e63a16f5912Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....369c9a35ffde691843a212f81236239e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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